Distribution of bacterial DNA repair proteins and their co-occurrence with immune systems
Summary: Bacteria encode various DNA repair pathways to maintain genome integrity. However, the high degree of homology between DNA repair proteins or their domains hampers accurate identification. Here, we describe a stringent search strategy to identify DNA repair proteins and provide a systematic...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S221112472401461X |
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| author | Sumanth K. Mutte Patrick Barendse Pilar Bobadilla Ugarte Daan C. Swarts |
| author_facet | Sumanth K. Mutte Patrick Barendse Pilar Bobadilla Ugarte Daan C. Swarts |
| author_sort | Sumanth K. Mutte |
| collection | DOAJ |
| description | Summary: Bacteria encode various DNA repair pathways to maintain genome integrity. However, the high degree of homology between DNA repair proteins or their domains hampers accurate identification. Here, we describe a stringent search strategy to identify DNA repair proteins and provide a systematic analysis of taxonomic distribution and co-occurrence of DNA repair proteins involved in RecA-dependent homologous recombination. Our results reveal the widespread presence of RecA, SSB, and RecOR proteins and phyla-specific distribution for the DNA repair complexes RecBCD, AddAB, and AdnAB. Furthermore, we report co-occurrences of DNA repair proteins with immune systems, including specific CRISPR-Cas subtypes, prokaryotic Argonautes (pAgos), dGTPases, GAPS2, and Wadjet. Our results imply that while certain DNA repair proteins and immune systems might function in conjunction, no immune system strictly relies on a specific DNA repair protein. As such, these findings offer an updated perspective on the distribution of DNA repair systems and their connection to immune systems in bacteria. |
| format | Article |
| id | doaj-art-39470e794eba49da993895e0b454646b |
| institution | Kabale University |
| issn | 2211-1247 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj-art-39470e794eba49da993895e0b454646b2025-01-03T04:08:38ZengElsevierCell Reports2211-12472025-01-01441115110Distribution of bacterial DNA repair proteins and their co-occurrence with immune systemsSumanth K. Mutte0Patrick Barendse1Pilar Bobadilla Ugarte2Daan C. Swarts3Laboratory of Biochemistry, Wageningen University, 6708 WE Wageningen, the Netherlands; MyGen Informatics, 6706 JE Wageningen, the NetherlandsLaboratory of Biochemistry, Wageningen University, 6708 WE Wageningen, the NetherlandsLaboratory of Biochemistry, Wageningen University, 6708 WE Wageningen, the NetherlandsLaboratory of Biochemistry, Wageningen University, 6708 WE Wageningen, the Netherlands; Corresponding authorSummary: Bacteria encode various DNA repair pathways to maintain genome integrity. However, the high degree of homology between DNA repair proteins or their domains hampers accurate identification. Here, we describe a stringent search strategy to identify DNA repair proteins and provide a systematic analysis of taxonomic distribution and co-occurrence of DNA repair proteins involved in RecA-dependent homologous recombination. Our results reveal the widespread presence of RecA, SSB, and RecOR proteins and phyla-specific distribution for the DNA repair complexes RecBCD, AddAB, and AdnAB. Furthermore, we report co-occurrences of DNA repair proteins with immune systems, including specific CRISPR-Cas subtypes, prokaryotic Argonautes (pAgos), dGTPases, GAPS2, and Wadjet. Our results imply that while certain DNA repair proteins and immune systems might function in conjunction, no immune system strictly relies on a specific DNA repair protein. As such, these findings offer an updated perspective on the distribution of DNA repair systems and their connection to immune systems in bacteria.http://www.sciencedirect.com/science/article/pii/S221112472401461XCP: Microbiology |
| spellingShingle | Sumanth K. Mutte Patrick Barendse Pilar Bobadilla Ugarte Daan C. Swarts Distribution of bacterial DNA repair proteins and their co-occurrence with immune systems Cell Reports CP: Microbiology |
| title | Distribution of bacterial DNA repair proteins and their co-occurrence with immune systems |
| title_full | Distribution of bacterial DNA repair proteins and their co-occurrence with immune systems |
| title_fullStr | Distribution of bacterial DNA repair proteins and their co-occurrence with immune systems |
| title_full_unstemmed | Distribution of bacterial DNA repair proteins and their co-occurrence with immune systems |
| title_short | Distribution of bacterial DNA repair proteins and their co-occurrence with immune systems |
| title_sort | distribution of bacterial dna repair proteins and their co occurrence with immune systems |
| topic | CP: Microbiology |
| url | http://www.sciencedirect.com/science/article/pii/S221112472401461X |
| work_keys_str_mv | AT sumanthkmutte distributionofbacterialdnarepairproteinsandtheircooccurrencewithimmunesystems AT patrickbarendse distributionofbacterialdnarepairproteinsandtheircooccurrencewithimmunesystems AT pilarbobadillaugarte distributionofbacterialdnarepairproteinsandtheircooccurrencewithimmunesystems AT daancswarts distributionofbacterialdnarepairproteinsandtheircooccurrencewithimmunesystems |