Prognostic value of albumin-bilirubin grade in lung cancer: a meta-analysis
Abstract Purpose To clarify the prognostic role of pretreatment albumin-bilirubin (ALBI) grade in lung cancer patients. Methods The PubMed, EMBASE, Web of Science and CNKI databases were searched up to April 20, 2024. Primary outcomes included the overall survival (OS), progression-free survival (PF...
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| Format: | Article |
| Language: | English |
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BMC
2024-12-01
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| Series: | Journal of Cardiothoracic Surgery |
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| Online Access: | https://doi.org/10.1186/s13019-024-03311-8 |
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| author | Jiao Jiang Hongjuan Li Lin Chen Xiaoming Qiu |
| author_facet | Jiao Jiang Hongjuan Li Lin Chen Xiaoming Qiu |
| author_sort | Jiao Jiang |
| collection | DOAJ |
| description | Abstract Purpose To clarify the prognostic role of pretreatment albumin-bilirubin (ALBI) grade in lung cancer patients. Methods The PubMed, EMBASE, Web of Science and CNKI databases were searched up to April 20, 2024. Primary outcomes included the overall survival (OS), progression-free survival (PFS) and cancer-specific survival (CSS). Hazard ratios (HRs) with 95% confidence intervals (CIs) were combined and subgroup analysis based on the type of lung cancer [non-small cell lung cancer (NSCLC) vs. small cell lung cancer (SCLC)] and treatment [surgery vs. immune checkpoint inhibitors (ICIs) vs. chemotherapy] was conducted. Results Eight studies with 2,057 patients were included. Pooled results indicated that elevated pretreatment ALBI grade was significantly related to poor OS (HR = 2.50, 95% CI: 2.03–3.09, P<0.001), PFS (HR = 1.91, 95% CI: 1.56–2.33, P<0.001) and CSS (HR = 1.90, 95% CI: 1.11–3.11, P = 0.018). Subgroup analysis for OS based on the pathological type and primary treatment manifested similar results. Conclusion Pretreatment ALBI grade is associated with prognosis in lung cancer and patients with elevated ALBI grade are more likely to experience worse survival. |
| format | Article |
| id | doaj-art-393c5be3649a4560bfc3b3edce2aebdc |
| institution | Kabale University |
| issn | 1749-8090 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Cardiothoracic Surgery |
| spelling | doaj-art-393c5be3649a4560bfc3b3edce2aebdc2025-01-05T12:45:48ZengBMCJournal of Cardiothoracic Surgery1749-80902024-12-011911910.1186/s13019-024-03311-8Prognostic value of albumin-bilirubin grade in lung cancer: a meta-analysisJiao Jiang0Hongjuan Li1Lin Chen2Xiaoming Qiu3Lung Cancer Center, West China Hospital, Sichuan University/West China School of Nursing, Sichuan UniversityLung Cancer Center, West China Hospital, Sichuan University/West China School of Nursing, Sichuan UniversityLung Cancer Center, West China Hospital, Sichuan University/West China School of Nursing, Sichuan UniversityDepartment of Thoracic Surgery/Lung Cancer Center, China Hospital, Sichuan UniversityAbstract Purpose To clarify the prognostic role of pretreatment albumin-bilirubin (ALBI) grade in lung cancer patients. Methods The PubMed, EMBASE, Web of Science and CNKI databases were searched up to April 20, 2024. Primary outcomes included the overall survival (OS), progression-free survival (PFS) and cancer-specific survival (CSS). Hazard ratios (HRs) with 95% confidence intervals (CIs) were combined and subgroup analysis based on the type of lung cancer [non-small cell lung cancer (NSCLC) vs. small cell lung cancer (SCLC)] and treatment [surgery vs. immune checkpoint inhibitors (ICIs) vs. chemotherapy] was conducted. Results Eight studies with 2,057 patients were included. Pooled results indicated that elevated pretreatment ALBI grade was significantly related to poor OS (HR = 2.50, 95% CI: 2.03–3.09, P<0.001), PFS (HR = 1.91, 95% CI: 1.56–2.33, P<0.001) and CSS (HR = 1.90, 95% CI: 1.11–3.11, P = 0.018). Subgroup analysis for OS based on the pathological type and primary treatment manifested similar results. Conclusion Pretreatment ALBI grade is associated with prognosis in lung cancer and patients with elevated ALBI grade are more likely to experience worse survival.https://doi.org/10.1186/s13019-024-03311-8Albumin-bilirubin gradePretreatmentLung cancerSurvivalMeta-analysis |
| spellingShingle | Jiao Jiang Hongjuan Li Lin Chen Xiaoming Qiu Prognostic value of albumin-bilirubin grade in lung cancer: a meta-analysis Journal of Cardiothoracic Surgery Albumin-bilirubin grade Pretreatment Lung cancer Survival Meta-analysis |
| title | Prognostic value of albumin-bilirubin grade in lung cancer: a meta-analysis |
| title_full | Prognostic value of albumin-bilirubin grade in lung cancer: a meta-analysis |
| title_fullStr | Prognostic value of albumin-bilirubin grade in lung cancer: a meta-analysis |
| title_full_unstemmed | Prognostic value of albumin-bilirubin grade in lung cancer: a meta-analysis |
| title_short | Prognostic value of albumin-bilirubin grade in lung cancer: a meta-analysis |
| title_sort | prognostic value of albumin bilirubin grade in lung cancer a meta analysis |
| topic | Albumin-bilirubin grade Pretreatment Lung cancer Survival Meta-analysis |
| url | https://doi.org/10.1186/s13019-024-03311-8 |
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