Cascade-catalysed nanocarrier degradation for regulating metabolism homeostasis and enhancing drug penetration on breast cancer

Cascade-catalysed nanocarrier degradation for regulating metabolism homeostasis and enhancing drug penetration on breast cancer

Abstract The abnormal structure of tumor vascular seriously hinders the delivery and deep penetration of drug in tumor therapy. Herein, an integrated and tumor microenvironment (TME)-responsive nanocarrier is designed, which can dilate vessle and improve the drug penetration by in situ releasing nit...

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Bibliographic Details
Main Authors: Fang Zhang, Kai Cheng, Xiao-Shuai Zhang, Sui Zhou, Jia-Hua Zou, Ming-Yu Tian, Xiao-Lin Hou, Yong-Guo Hu, Jing Yuan, Jin-Xuan Fan, Yuan-Di Zhao, Tian-Cai Liu
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Journal of Nanobiotechnology
Subjects:
Glutathione
Metabolism homeostasis
Nitric oxide
Drug penetration
Cell cycle
Online Access:https://doi.org/10.1186/s12951-024-02948-w
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