Gastric cancer-derived exosomal let-7 g-5p mediated by SERPINE1 promotes macrophage M2 polarization and gastric cancer progression

Gastric cancer-derived exosomal let-7 g-5p mediated by SERPINE1 promotes macrophage M2 polarization and gastric cancer progression

Highlights SERPINE1 mediates the transfer of cancer-derived exosomal let-7 g-5p to promote macrophage M2 polarization. Exosomal let-7 g-5p drives M2 polarization by downregulating SOCS7 and relieving its inhibition of STAT3 phosphorylation. SERPINE1 promotes the transcription of let-7 g-5p by activa...

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Bibliographic Details
Main Authors: Zhenzhen Ye, Jianfeng Yi, Xiangyan Jiang, Wengui Shi, Hao Xu, Hongtai Cao, Long Qin, Lixin Liu, Tianming Wang, Zhijian Ma, Zuoyi Jiao
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Gastric cancer
SERPINE1/PAI-1
let-7 g-5p
Cancer-derived exosome
M2 polarization
Online Access:https://doi.org/10.1186/s13046-024-03269-4
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