PREDICTORS OF INTRALUMINAL RECURRENCE AT THE ANASTOMOSIS SITE AFTER CURATIVE RESECTION FOR COLON CANCER
Objective: The increase in the number of patients recovering from colon cancer after primary resection inevitably increases the number of patients with local recurrence. This study was conducted to investigate the predictors of intraluminal recurrence at the anastomosis site in patients who underwen...
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| Format: | Article |
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Istanbul University Press
2024-07-01
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| Series: | İstanbul Tıp Fakültesi Dergisi |
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| Online Access: | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/55B74322ED5E4E1AAF11690119E5B51D |
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| author | İlker Özgür Burak Çelik Melek Büyük Cemalettin Ertekin Mehmet Türker Bulut Metin Keskin |
| author_facet | İlker Özgür Burak Çelik Melek Büyük Cemalettin Ertekin Mehmet Türker Bulut Metin Keskin |
| author_sort | İlker Özgür |
| collection | DOAJ |
| description | Objective: The increase in the number of patients recovering from colon cancer after primary resection inevitably increases the number of patients with local recurrence. This study was conducted to investigate the predictors of intraluminal recurrence at the anastomosis site in patients who underwent curative resection for colon cancer. Material and Method: This study included 160 patients who underwent curative resection for colon cancer and had completed follow-up colonoscopy and surveillance for at least two years at our tertiary referral hospital. Patients with intraluminal recurrence were compared with those without locally recurrent disease. Patient data, including demographics, tumor characteristics, surgery type, and reconstruction technique, were reviewed. Result: The median age of the study group was 61 years, and 60% were men. A total of 25 (15.6%) patients had only intraluminal recurrence at the anastomosis site. The median time to intraluminal recurrence was 21.3 months (range, 3–71 months). Univariate analysis revealed the histopathological type, histological grade, T stage, number of metastatic lymph nodes, tumor margins, presence of tumor budding, perineural invasion, and anastomosis type as risk factors for intraluminal recurrence. Multivariate analysis revealed handsewn anastomoses (odds ratio [OR]: 45.532; 95% confidence interval (CI): 5.278–392.778), T stage (OR: 3.593; 95% CI: 1.378–9.371), and the presence of tumor budding (OR: 3.912; 95% CI: 1.306–11.715) as independent risk factors. Adjuvant chemotherapy did not affect the rate of intraluminal recurrence. Conclusion: This study suggests a relationship between tumor biology and intraluminal recurrence, and the T stage and tumor budding were the predictors. |
| format | Article |
| id | doaj-art-38f84055738f4c9890a26e009276bfc0 |
| institution | Kabale University |
| issn | 1305-6441 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Istanbul University Press |
| record_format | Article |
| series | İstanbul Tıp Fakültesi Dergisi |
| spelling | doaj-art-38f84055738f4c9890a26e009276bfc02025-08-20T03:52:47ZengIstanbul University Pressİstanbul Tıp Fakültesi Dergisi1305-64412024-07-0187318519310.26650/IUITFD.1428549123456PREDICTORS OF INTRALUMINAL RECURRENCE AT THE ANASTOMOSIS SITE AFTER CURATIVE RESECTION FOR COLON CANCERİlker Özgür0https://orcid.org/0000-0003-1499-0503Burak Çelik1https://orcid.org/0000-0002-8626-7675Melek Büyük2https://orcid.org/0000-0003-3425-2137Cemalettin Ertekin3https://orcid.org/0000-0002-8052-1628Mehmet Türker Bulut4https://orcid.org/0000-0001-5903-4721Metin Keskin5https://orcid.org/0000-0002-5390-2185İstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, TürkiyeObjective: The increase in the number of patients recovering from colon cancer after primary resection inevitably increases the number of patients with local recurrence. This study was conducted to investigate the predictors of intraluminal recurrence at the anastomosis site in patients who underwent curative resection for colon cancer. Material and Method: This study included 160 patients who underwent curative resection for colon cancer and had completed follow-up colonoscopy and surveillance for at least two years at our tertiary referral hospital. Patients with intraluminal recurrence were compared with those without locally recurrent disease. Patient data, including demographics, tumor characteristics, surgery type, and reconstruction technique, were reviewed. Result: The median age of the study group was 61 years, and 60% were men. A total of 25 (15.6%) patients had only intraluminal recurrence at the anastomosis site. The median time to intraluminal recurrence was 21.3 months (range, 3–71 months). Univariate analysis revealed the histopathological type, histological grade, T stage, number of metastatic lymph nodes, tumor margins, presence of tumor budding, perineural invasion, and anastomosis type as risk factors for intraluminal recurrence. Multivariate analysis revealed handsewn anastomoses (odds ratio [OR]: 45.532; 95% confidence interval (CI): 5.278–392.778), T stage (OR: 3.593; 95% CI: 1.378–9.371), and the presence of tumor budding (OR: 3.912; 95% CI: 1.306–11.715) as independent risk factors. Adjuvant chemotherapy did not affect the rate of intraluminal recurrence. Conclusion: This study suggests a relationship between tumor biology and intraluminal recurrence, and the T stage and tumor budding were the predictors.https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/55B74322ED5E4E1AAF11690119E5B51Dcolon cancerintraluminal recurrenceanastomosis site recurrencerisk factors |
| spellingShingle | İlker Özgür Burak Çelik Melek Büyük Cemalettin Ertekin Mehmet Türker Bulut Metin Keskin PREDICTORS OF INTRALUMINAL RECURRENCE AT THE ANASTOMOSIS SITE AFTER CURATIVE RESECTION FOR COLON CANCER İstanbul Tıp Fakültesi Dergisi colon cancer intraluminal recurrence anastomosis site recurrence risk factors |
| title | PREDICTORS OF INTRALUMINAL RECURRENCE AT THE ANASTOMOSIS SITE AFTER CURATIVE RESECTION FOR COLON CANCER |
| title_full | PREDICTORS OF INTRALUMINAL RECURRENCE AT THE ANASTOMOSIS SITE AFTER CURATIVE RESECTION FOR COLON CANCER |
| title_fullStr | PREDICTORS OF INTRALUMINAL RECURRENCE AT THE ANASTOMOSIS SITE AFTER CURATIVE RESECTION FOR COLON CANCER |
| title_full_unstemmed | PREDICTORS OF INTRALUMINAL RECURRENCE AT THE ANASTOMOSIS SITE AFTER CURATIVE RESECTION FOR COLON CANCER |
| title_short | PREDICTORS OF INTRALUMINAL RECURRENCE AT THE ANASTOMOSIS SITE AFTER CURATIVE RESECTION FOR COLON CANCER |
| title_sort | predictors of intraluminal recurrence at the anastomosis site after curative resection for colon cancer |
| topic | colon cancer intraluminal recurrence anastomosis site recurrence risk factors |
| url | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/55B74322ED5E4E1AAF11690119E5B51D |
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