Developmental and functional roles of androgen and interactive signals for external genitalia and erectile tissues
Abstract Background Recent progress in molecular and signal analyses revealed essential functions of cellular signals including androgen and related growth factors such as Wnt regulators for external genitalia (ExG) development and its pathogenesis. Accumulated data showed their fundamental function...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Reproductive Medicine and Biology |
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| Online Access: | https://doi.org/10.1002/rmb2.12611 |
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| author | Daiki Hashimoto Kota Fujimoto Masanori Nakata Takuya Suzuki Shinji Kumegawa Yuko Ueda Kentaro Suzuki Shinichi Asamura Gen Yamada |
| author_facet | Daiki Hashimoto Kota Fujimoto Masanori Nakata Takuya Suzuki Shinji Kumegawa Yuko Ueda Kentaro Suzuki Shinichi Asamura Gen Yamada |
| author_sort | Daiki Hashimoto |
| collection | DOAJ |
| description | Abstract Background Recent progress in molecular and signal analyses revealed essential functions of cellular signals including androgen and related growth factors such as Wnt regulators for external genitalia (ExG) development and its pathogenesis. Accumulated data showed their fundamental functions also for erectile tissue (corporal body) development and its abnormalities. The current review focuses on such signals from developmental and functional viewpoints. Methods Experimental strategies including histological and molecular signal analyses with conditional mutant mice for androgen and Wnt signals have been extensively utilized. Main findings Essential roles of androgen for the development of male‐type ExG and urethral formation are shown. Wnt signals are associated with androgen for male‐type ExG organogenesis. Androgen plays essential roles in the development of erectile tissue, the corporal body and it also regulates the duration time of erection. Wnt and other signals are essential for the regulation of mesenchymal cells of erectile tissue as shown by its conditional mutant mouse analyses. Stress signals, continuous erection, and the potential of lymphatic characteristics of the erectile vessels with sinusoids are also shown. Conclusion Reiterated involvement of androgen, Wnt, and other regulatory factors is stated for the development and pathogenesis of ExG and erectile tissues. |
| format | Article |
| id | doaj-art-38c4dd34b6dd4d9fbddad9b730ff6702 |
| institution | Kabale University |
| issn | 1445-5781 1447-0578 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Reproductive Medicine and Biology |
| spelling | doaj-art-38c4dd34b6dd4d9fbddad9b730ff67022024-12-20T06:08:37ZengWileyReproductive Medicine and Biology1445-57811447-05782024-01-01231n/an/a10.1002/rmb2.12611Developmental and functional roles of androgen and interactive signals for external genitalia and erectile tissuesDaiki Hashimoto0Kota Fujimoto1Masanori Nakata2Takuya Suzuki3Shinji Kumegawa4Yuko Ueda5Kentaro Suzuki6Shinichi Asamura7Gen Yamada8Department of Physiology, Faculty of Medicine Wakayama Medical University Wakayama JapanDepartment of Urology Urological Science Institute, Yonsei University College of Medicine Seoul South KoreaDepartment of Physiology, Faculty of Medicine Wakayama Medical University Wakayama JapanDepartment of Plastic and Reconstructive Surgery Wakayama Medical University Wakayama JapanDepartment of Plastic and Reconstructive Surgery Wakayama Medical University Wakayama JapanDepartment of Urology Osaka Women's and Children's Hospital Osaka JapanFaculty of Life and Environmental Sciences University of Yamanashi Yamanashi JapanDepartment of Plastic and Reconstructive Surgery Wakayama Medical University Wakayama JapanDepartment of Plastic and Reconstructive Surgery Wakayama Medical University Wakayama JapanAbstract Background Recent progress in molecular and signal analyses revealed essential functions of cellular signals including androgen and related growth factors such as Wnt regulators for external genitalia (ExG) development and its pathogenesis. Accumulated data showed their fundamental functions also for erectile tissue (corporal body) development and its abnormalities. The current review focuses on such signals from developmental and functional viewpoints. Methods Experimental strategies including histological and molecular signal analyses with conditional mutant mice for androgen and Wnt signals have been extensively utilized. Main findings Essential roles of androgen for the development of male‐type ExG and urethral formation are shown. Wnt signals are associated with androgen for male‐type ExG organogenesis. Androgen plays essential roles in the development of erectile tissue, the corporal body and it also regulates the duration time of erection. Wnt and other signals are essential for the regulation of mesenchymal cells of erectile tissue as shown by its conditional mutant mouse analyses. Stress signals, continuous erection, and the potential of lymphatic characteristics of the erectile vessels with sinusoids are also shown. Conclusion Reiterated involvement of androgen, Wnt, and other regulatory factors is stated for the development and pathogenesis of ExG and erectile tissues.https://doi.org/10.1002/rmb2.12611androgencorpus cavernosumEDerectionexternal genitalia |
| spellingShingle | Daiki Hashimoto Kota Fujimoto Masanori Nakata Takuya Suzuki Shinji Kumegawa Yuko Ueda Kentaro Suzuki Shinichi Asamura Gen Yamada Developmental and functional roles of androgen and interactive signals for external genitalia and erectile tissues Reproductive Medicine and Biology androgen corpus cavernosum ED erection external genitalia |
| title | Developmental and functional roles of androgen and interactive signals for external genitalia and erectile tissues |
| title_full | Developmental and functional roles of androgen and interactive signals for external genitalia and erectile tissues |
| title_fullStr | Developmental and functional roles of androgen and interactive signals for external genitalia and erectile tissues |
| title_full_unstemmed | Developmental and functional roles of androgen and interactive signals for external genitalia and erectile tissues |
| title_short | Developmental and functional roles of androgen and interactive signals for external genitalia and erectile tissues |
| title_sort | developmental and functional roles of androgen and interactive signals for external genitalia and erectile tissues |
| topic | androgen corpus cavernosum ED erection external genitalia |
| url | https://doi.org/10.1002/rmb2.12611 |
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