Relationship between sonorheometry parameters and laboratory values in a critical care setting in Italy: a retrospective cohort study
Purpose This preliminary retrospective cohort study analyzed the relationship between the parameters provided by sonorheometry device Quantra and the coagulation values obtained from standard venous blood samples in patients admitted in intensive care unit (ICU). Methods We reviewed medical charts o...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Society of Traumatology
2023-09-01
|
| Series: | Journal of Trauma and Injury |
| Subjects: | |
| Online Access: | http://jtraumainj.org/upload/pdf/jti-2023-0014.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841527013668552704 |
|---|---|
| author | Antonio Romanelli Renato Gammaldi Alessandro Calicchio Salvatore Palmese Antonio Siglioccolo |
| author_facet | Antonio Romanelli Renato Gammaldi Alessandro Calicchio Salvatore Palmese Antonio Siglioccolo |
| author_sort | Antonio Romanelli |
| collection | DOAJ |
| description | Purpose This preliminary retrospective cohort study analyzed the relationship between the parameters provided by sonorheometry device Quantra and the coagulation values obtained from standard venous blood samples in patients admitted in intensive care unit (ICU). Methods We reviewed medical charts of 13 ICU adult patients in whom at least one coagulation study with Quantra was performed. The relationship between Quantra and laboratory data was analyzed with the Spearman rank correlation coefficient (rho). The 95% confidence interval (CI) was computed. A P-value <0.05 was considered statistically significant. Results We collected 28 data pairs. Statistically significant moderate correlations were found for the following parameters: clot time (CT) and activated partial thromboplastin time (rho=0.516; 95% CI, 0.123–0.904; P=0.009; clot stiffness (CS) and the international normalized ratio (INR; rho=0.418; 95% CI, 0.042–0.787; P=0.039); INR and platelet contribution to CS (rho=0.459; 95% CI, 0.077–0.836; P=0.022); platelet count and platelet contribution to CS (PCS; rho=0.498; 95% CI, 0.166–0.825; P=0.008); and fibrinogen and fibrinogen contribution to CS (FCS; rho=0.620; 95% CI, 0.081–0.881; P=0.001). Conclusions Quantra can provide useful information regarding coagulation status, showing modest correlations with the parameters obtained from laboratory tests. During diffuse bleeding, CT and FCS values can guide the proper administration of clotting factors and fibrinogens. However, the correlation of INR with CS and PCS can cause misinterpretation. Further studies are needed to clarify the relationship between Quantra parameters and laboratory tests in the critical care setting and the role of sonorheometry in guiding targeted therapies and improving outcomes. |
| format | Article |
| id | doaj-art-389c4b416b174925ae084a6537f3537a |
| institution | Kabale University |
| issn | 2799-4317 2287-1683 |
| language | English |
| publishDate | 2023-09-01 |
| publisher | Korean Society of Traumatology |
| record_format | Article |
| series | Journal of Trauma and Injury |
| spelling | doaj-art-389c4b416b174925ae084a6537f3537a2025-01-16T05:40:00ZengKorean Society of TraumatologyJournal of Trauma and Injury2799-43172287-16832023-09-0136321021610.20408/jti.2023.00141253Relationship between sonorheometry parameters and laboratory values in a critical care setting in Italy: a retrospective cohort studyAntonio Romanelli0Renato Gammaldi1Alessandro Calicchio2Salvatore Palmese3Antonio Siglioccolo4 Department of Anesthesia and Intensive Care Unit, Azienda Ospedaliero Universitaria San Giovanni di Dio Ruggi d’Aragona, Salerno, Italy Department of Anesthesia and Intensive Care Unit, Azienda Ospedaliero Universitaria San Giovanni di Dio Ruggi d’Aragona, Salerno, Italy Department of Anesthesia and Intensive Care, University of Naples Federico II, Naples, Italy Department of Anesthesia and Intensive Care Unit, Azienda Ospedaliero Universitaria San Giovanni di Dio Ruggi d’Aragona, Salerno, Italy Department of Anesthesia and Intensive Care Unit, Azienda Ospedaliero Universitaria San Giovanni di Dio Ruggi d’Aragona, Salerno, ItalyPurpose This preliminary retrospective cohort study analyzed the relationship between the parameters provided by sonorheometry device Quantra and the coagulation values obtained from standard venous blood samples in patients admitted in intensive care unit (ICU). Methods We reviewed medical charts of 13 ICU adult patients in whom at least one coagulation study with Quantra was performed. The relationship between Quantra and laboratory data was analyzed with the Spearman rank correlation coefficient (rho). The 95% confidence interval (CI) was computed. A P-value <0.05 was considered statistically significant. Results We collected 28 data pairs. Statistically significant moderate correlations were found for the following parameters: clot time (CT) and activated partial thromboplastin time (rho=0.516; 95% CI, 0.123–0.904; P=0.009; clot stiffness (CS) and the international normalized ratio (INR; rho=0.418; 95% CI, 0.042–0.787; P=0.039); INR and platelet contribution to CS (rho=0.459; 95% CI, 0.077–0.836; P=0.022); platelet count and platelet contribution to CS (PCS; rho=0.498; 95% CI, 0.166–0.825; P=0.008); and fibrinogen and fibrinogen contribution to CS (FCS; rho=0.620; 95% CI, 0.081–0.881; P=0.001). Conclusions Quantra can provide useful information regarding coagulation status, showing modest correlations with the parameters obtained from laboratory tests. During diffuse bleeding, CT and FCS values can guide the proper administration of clotting factors and fibrinogens. However, the correlation of INR with CS and PCS can cause misinterpretation. Further studies are needed to clarify the relationship between Quantra parameters and laboratory tests in the critical care setting and the role of sonorheometry in guiding targeted therapies and improving outcomes.http://jtraumainj.org/upload/pdf/jti-2023-0014.pdfblood coagulationpoint-of-care testingnonparametric statistics |
| spellingShingle | Antonio Romanelli Renato Gammaldi Alessandro Calicchio Salvatore Palmese Antonio Siglioccolo Relationship between sonorheometry parameters and laboratory values in a critical care setting in Italy: a retrospective cohort study Journal of Trauma and Injury blood coagulation point-of-care testing nonparametric statistics |
| title | Relationship between sonorheometry parameters and laboratory values in a critical care setting in Italy: a retrospective cohort study |
| title_full | Relationship between sonorheometry parameters and laboratory values in a critical care setting in Italy: a retrospective cohort study |
| title_fullStr | Relationship between sonorheometry parameters and laboratory values in a critical care setting in Italy: a retrospective cohort study |
| title_full_unstemmed | Relationship between sonorheometry parameters and laboratory values in a critical care setting in Italy: a retrospective cohort study |
| title_short | Relationship between sonorheometry parameters and laboratory values in a critical care setting in Italy: a retrospective cohort study |
| title_sort | relationship between sonorheometry parameters and laboratory values in a critical care setting in italy a retrospective cohort study |
| topic | blood coagulation point-of-care testing nonparametric statistics |
| url | http://jtraumainj.org/upload/pdf/jti-2023-0014.pdf |
| work_keys_str_mv | AT antonioromanelli relationshipbetweensonorheometryparametersandlaboratoryvaluesinacriticalcaresettinginitalyaretrospectivecohortstudy AT renatogammaldi relationshipbetweensonorheometryparametersandlaboratoryvaluesinacriticalcaresettinginitalyaretrospectivecohortstudy AT alessandrocalicchio relationshipbetweensonorheometryparametersandlaboratoryvaluesinacriticalcaresettinginitalyaretrospectivecohortstudy AT salvatorepalmese relationshipbetweensonorheometryparametersandlaboratoryvaluesinacriticalcaresettinginitalyaretrospectivecohortstudy AT antoniosiglioccolo relationshipbetweensonorheometryparametersandlaboratoryvaluesinacriticalcaresettinginitalyaretrospectivecohortstudy |