Edible plant Artemisia argyi H.Lév. & Vaniot: An in vitro study on its anti-Helicobacter pylori effect
A. argyi is a renowned herb widely used in food and medicine, offering significant economic benefits. H. pylori, a known carcinogen, is associated with numerous diseases. Current treatments primarily rely on antibiotics, but rising resistance has reduced their efficacy. The activity and mechanisms o...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464624006510 |
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| author | Meiyun Chen Sheng Pan Fengli Lin Weixing Zhu Baojie Li Bing Zhou Guimin Zhang Zhong Feng Meicun Yao |
| author_facet | Meiyun Chen Sheng Pan Fengli Lin Weixing Zhu Baojie Li Bing Zhou Guimin Zhang Zhong Feng Meicun Yao |
| author_sort | Meiyun Chen |
| collection | DOAJ |
| description | A. argyi is a renowned herb widely used in food and medicine, offering significant economic benefits. H. pylori, a known carcinogen, is associated with numerous diseases. Current treatments primarily rely on antibiotics, but rising resistance has reduced their efficacy. The activity and mechanisms of A. argyi against H. pylori infection remain unclear. A. argyi exhibited strong bacteriostatic and bactericidal effects against multiple H. pylori. It demonstrated no antagonistic effects when combined with antibiotics and disrupted H. pylori morphology and structure, downregulated various virulence genes, and inhibited urease activity. In co-culture systems, A. argyi reduced H. pylori adhesion, urease levels, and NO production, indicating immunomodulatory activity. Among the five components of A. argyi with anti-H. pylori activity, jaceosidin exhibited the strongest effect (MIC: 10 μg/mL), followed by eupatilin. Methylation of jaceosidin reduced its anti-H. pylori activity. A. argyi is an edible herb with anti- H. pylori activity and excellent safety. |
| format | Article |
| id | doaj-art-3828207b39aa40f29313824ce1986613 |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-3828207b39aa40f29313824ce19866132025-01-12T05:24:47ZengElsevierJournal of Functional Foods1756-46462025-01-01124106648Edible plant Artemisia argyi H.Lév. & Vaniot: An in vitro study on its anti-Helicobacter pylori effectMeiyun Chen0Sheng Pan1Fengli Lin2Weixing Zhu3Baojie Li4Bing Zhou5Guimin Zhang6Zhong Feng7Meicun Yao8School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, ChinaDepartment of Medicinal Chemistry, School of Pharmacy, Qingdao University, Qingdao, Shandong 266021, ChinaGraduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, ChinaQingyuan Hospital of Traditional Chinese Medicine, Qingyuan 511500, ChinaInternational Pharmaceutical Engineering Lab of Shandong Province, Feixian 273400, China; State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, Lunan Pharmaceutical Group Co. Ltd., Linyi 276005, ChinaInternational Pharmaceutical Engineering Lab of Shandong Province, Feixian 273400, China; State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, Lunan Pharmaceutical Group Co. Ltd., Linyi 276005, ChinaInternational Pharmaceutical Engineering Lab of Shandong Province, Feixian 273400, China; State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, Lunan Pharmaceutical Group Co. Ltd., Linyi 276005, China; Corresponding authors at: International Pharmaceutical Engineering Lab of Shandong Province, Feixian 273400, China.School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China; International Pharmaceutical Engineering Lab of Shandong Province, Feixian 273400, China; State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, Lunan Pharmaceutical Group Co. Ltd., Linyi 276005, China; Corresponding authors at: International Pharmaceutical Engineering Lab of Shandong Province, Feixian 273400, China.School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China; Nanchang Research Institute, Sun Yat-sen University, Jiangxi 330096, China; Corresponding author at: School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China.A. argyi is a renowned herb widely used in food and medicine, offering significant economic benefits. H. pylori, a known carcinogen, is associated with numerous diseases. Current treatments primarily rely on antibiotics, but rising resistance has reduced their efficacy. The activity and mechanisms of A. argyi against H. pylori infection remain unclear. A. argyi exhibited strong bacteriostatic and bactericidal effects against multiple H. pylori. It demonstrated no antagonistic effects when combined with antibiotics and disrupted H. pylori morphology and structure, downregulated various virulence genes, and inhibited urease activity. In co-culture systems, A. argyi reduced H. pylori adhesion, urease levels, and NO production, indicating immunomodulatory activity. Among the five components of A. argyi with anti-H. pylori activity, jaceosidin exhibited the strongest effect (MIC: 10 μg/mL), followed by eupatilin. Methylation of jaceosidin reduced its anti-H. pylori activity. A. argyi is an edible herb with anti- H. pylori activity and excellent safety.http://www.sciencedirect.com/science/article/pii/S1756464624006510Artemisia argyi H.Lév. & VaniotPhytochemical compositionHelicobacter pyloriJaceosidinAdhesionMechanism of action |
| spellingShingle | Meiyun Chen Sheng Pan Fengli Lin Weixing Zhu Baojie Li Bing Zhou Guimin Zhang Zhong Feng Meicun Yao Edible plant Artemisia argyi H.Lév. & Vaniot: An in vitro study on its anti-Helicobacter pylori effect Journal of Functional Foods Artemisia argyi H.Lév. & Vaniot Phytochemical composition Helicobacter pylori Jaceosidin Adhesion Mechanism of action |
| title | Edible plant Artemisia argyi H.Lév. & Vaniot: An in vitro study on its anti-Helicobacter pylori effect |
| title_full | Edible plant Artemisia argyi H.Lév. & Vaniot: An in vitro study on its anti-Helicobacter pylori effect |
| title_fullStr | Edible plant Artemisia argyi H.Lév. & Vaniot: An in vitro study on its anti-Helicobacter pylori effect |
| title_full_unstemmed | Edible plant Artemisia argyi H.Lév. & Vaniot: An in vitro study on its anti-Helicobacter pylori effect |
| title_short | Edible plant Artemisia argyi H.Lév. & Vaniot: An in vitro study on its anti-Helicobacter pylori effect |
| title_sort | edible plant artemisia argyi h lev amp vaniot an in vitro study on its anti helicobacter pylori effect |
| topic | Artemisia argyi H.Lév. & Vaniot Phytochemical composition Helicobacter pylori Jaceosidin Adhesion Mechanism of action |
| url | http://www.sciencedirect.com/science/article/pii/S1756464624006510 |
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