Comparative study of trastuzumab modification analysis using mono/multi-epitope affinity technology with LC-QTOF-MS

Comparative study of trastuzumab modification analysis using mono/multi-epitope affinity technology with LC-QTOF-MS

Dynamic tracking analysis of monoclonal antibodies (mAbs) biotransformation in vivo is crucial, as certain modifications could inactivate the protein and reduce drug efficacy. However, a particular challenge (i.e. immune recognition deficiencies) in biotransformation studies may arise when modificat...

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Bibliographic Details
Main Authors:	Chengyi Zuo, Jingwei Zhou, Sumin Bian, Qing Zhang, Yutian Lei, Yuan Shen, Zhiwei Chen, Peijun Ye, Leying Shi, Mao Mu, Jia-Huan Qu, Zhengjin Jiang, Qiqin Wang
Format:	Article
Language:	English
Published:	Elsevier 2024-11-01
Series:	Journal of Pharmaceutical Analysis
Subjects:	Monoclonal antibody Multi-epitope affinity technology Biotransformation analysis LC-QTOF-MS Breast cancer
Online Access:	http://www.sciencedirect.com/science/article/pii/S2095177924001126
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