HDL meets triglyceride
Abstract: The study by Liu et al in this issue of the Journal of Lipid Research leverages data from the UK Biobank to explore the impact of HDL-TG on atherosclerotic cardiovascular disease risk. The investigators observed that elevated serum triglyceride levels were associated with reduced HDL parti...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-05-01
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| Series: | Journal of Lipid Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227525000562 |
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| _version_ | 1849313889343242240 |
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| author | Tugce Akcan Fredric B. Kraemer |
| author_facet | Tugce Akcan Fredric B. Kraemer |
| author_sort | Tugce Akcan |
| collection | DOAJ |
| description | Abstract: The study by Liu et al in this issue of the Journal of Lipid Research leverages data from the UK Biobank to explore the impact of HDL-TG on atherosclerotic cardiovascular disease risk. The investigators observed that elevated serum triglyceride levels were associated with reduced HDL particle diameter and with increased HDL-TG. Using observational and Mendelian randomization analyses, HDL-TG levels were independently associated with atherosclerotic cardiovascular disease risk even after adjusting for multiple confounders and other risk factors. The results emphasize the need for a broader evaluation of lipid parameters that extends beyond traditional measurements and suggest that incorporating metrics like HDL-TG could enhance risk stratification. |
| format | Article |
| id | doaj-art-37eaa84a8a0f48bd96e373f316f60e65 |
| institution | Kabale University |
| issn | 0022-2275 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj-art-37eaa84a8a0f48bd96e373f316f60e652025-08-20T03:52:38ZengElsevierJournal of Lipid Research0022-22752025-05-0166510079610.1016/j.jlr.2025.100796HDL meets triglycerideTugce Akcan0Fredric B. Kraemer1Division of Endocrinology, Gerontology and Metabolism, Stanford University School of Medicine, Stanford, CA, USAFor correspondence: Fredric B. Kraemer; Division of Endocrinology, Gerontology and Metabolism, Stanford University School of Medicine, Stanford, CA, USAAbstract: The study by Liu et al in this issue of the Journal of Lipid Research leverages data from the UK Biobank to explore the impact of HDL-TG on atherosclerotic cardiovascular disease risk. The investigators observed that elevated serum triglyceride levels were associated with reduced HDL particle diameter and with increased HDL-TG. Using observational and Mendelian randomization analyses, HDL-TG levels were independently associated with atherosclerotic cardiovascular disease risk even after adjusting for multiple confounders and other risk factors. The results emphasize the need for a broader evaluation of lipid parameters that extends beyond traditional measurements and suggest that incorporating metrics like HDL-TG could enhance risk stratification.http://www.sciencedirect.com/science/article/pii/S0022227525000562cardiovascular riskHDLtriglycerides |
| spellingShingle | Tugce Akcan Fredric B. Kraemer HDL meets triglyceride Journal of Lipid Research cardiovascular risk HDL triglycerides |
| title | HDL meets triglyceride |
| title_full | HDL meets triglyceride |
| title_fullStr | HDL meets triglyceride |
| title_full_unstemmed | HDL meets triglyceride |
| title_short | HDL meets triglyceride |
| title_sort | hdl meets triglyceride |
| topic | cardiovascular risk HDL triglycerides |
| url | http://www.sciencedirect.com/science/article/pii/S0022227525000562 |
| work_keys_str_mv | AT tugceakcan hdlmeetstriglyceride AT fredricbkraemer hdlmeetstriglyceride |