Simultaneous non-contrast assessment of cardiac microstructure and perfusion in vivo in the human heart
ABSTRACT: Background: Intravoxel incoherent motion (IVIM) imaging can provide information on cardiac microstructure and microvascular perfusion from a single examination. However, the spin echo-based approaches typically used for cardiac IVIM suffer from low sensitivity to changes in perfusion. The...
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Elsevier
2025-01-01
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| Series: | Journal of Cardiovascular Magnetic Resonance |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1097664724011566 |
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| author | Camila Munoz Eunji Lim Pedro F. Ferreira Dudley J. Pennell Sonia Nielles-Vallespin Andrew D. Scott |
| author_facet | Camila Munoz Eunji Lim Pedro F. Ferreira Dudley J. Pennell Sonia Nielles-Vallespin Andrew D. Scott |
| author_sort | Camila Munoz |
| collection | DOAJ |
| description | ABSTRACT: Background: Intravoxel incoherent motion (IVIM) imaging can provide information on cardiac microstructure and microvascular perfusion from a single examination. However, the spin echo-based approaches typically used for cardiac IVIM suffer from low sensitivity to changes in perfusion. The aim of this work was to develop a stimulated-echo (STEAM)-based method for IVIM and diffusion tensor cardiovascular magnetic resonance to simultaneously provide biomarkers of microstructure and perfusion in vivo in the human heart. Methods: Here we introduce a novel STEAM-IVIM sequence incorporating phase cycling to obtain true non-diffusion weighted images (b = 0 s/mm2). STEAM-IVIM imaging was performed at 20 b-values (0 to 1000 s/mm2) to enable accurate estimation of the IVIM parameters, and with six diffusion encoding directions to enable reconstruction of the diffusion tensor. 20 healthy subjects (8 female, median age 31 years) were imaged on a clinical 3T system with STEAM-IVIM. A simulation study was performed to investigate the optimal fitting algorithms for the IVIM parameters, which was subsequently used to create pixel-wise IVIM parameter maps for the in vivo acquisitions. Results: Good image quality across the myocardium was obtained for all b-values. Mean(±SD) IVIM parameter estimates were: diffusivity D = 0.83 ± 0.07 × 10-3 mm2/s, perfusion coefficient D* = 19.08 ± 6.48 × 10-3 mm2/s, perfusion fraction f = 19.72 ± 4.11%, and mean diffusion tensor parameters were: mean diffusivity = 0.88 ± 0.06 × 10-3 mm2/s, fractional anisotropy = 0.45 ± 0.04, absolute E2 angle = 55.29 ± 6.38º, helix angle gradient = -0.68 ± 0.18º/%. Conclusion: Phase-cycled STEAM-IVIM enables fitting of cardiac diffusion tensor and perfusion parameters in healthy subjects and shows promise for the simultaneous detection of microstructural aberration and perfusion abnormalities in the presence of cardiac disease without the need for exogenous contrast agents. |
| format | Article |
| id | doaj-art-37bc57dfd121434eb522d8f2576de492 |
| institution | Kabale University |
| issn | 1097-6647 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Cardiovascular Magnetic Resonance |
| spelling | doaj-art-37bc57dfd121434eb522d8f2576de4922025-01-05T04:27:50ZengElsevierJournal of Cardiovascular Magnetic Resonance1097-66472025-01-01271101129Simultaneous non-contrast assessment of cardiac microstructure and perfusion in vivo in the human heartCamila Munoz0Eunji Lim1Pedro F. Ferreira2Dudley J. Pennell3Sonia Nielles-Vallespin4Andrew D. Scott5National Heart and Lung Institute, Imperial College London, London, UK; Royal Brompton and Harefield Hospitals, Guy’s and St Thomas’ NHS Foundation Trust, London, UK; Corresponding author.National Heart and Lung Institute, Imperial College London, London, UK; Royal Brompton and Harefield Hospitals, Guy’s and St Thomas’ NHS Foundation Trust, London, UKNational Heart and Lung Institute, Imperial College London, London, UK; Royal Brompton and Harefield Hospitals, Guy’s and St Thomas’ NHS Foundation Trust, London, UKNational Heart and Lung Institute, Imperial College London, London, UK; Royal Brompton and Harefield Hospitals, Guy’s and St Thomas’ NHS Foundation Trust, London, UKNational Heart and Lung Institute, Imperial College London, London, UK; Royal Brompton and Harefield Hospitals, Guy’s and St Thomas’ NHS Foundation Trust, London, UKNational Heart and Lung Institute, Imperial College London, London, UK; Royal Brompton and Harefield Hospitals, Guy’s and St Thomas’ NHS Foundation Trust, London, UKABSTRACT: Background: Intravoxel incoherent motion (IVIM) imaging can provide information on cardiac microstructure and microvascular perfusion from a single examination. However, the spin echo-based approaches typically used for cardiac IVIM suffer from low sensitivity to changes in perfusion. The aim of this work was to develop a stimulated-echo (STEAM)-based method for IVIM and diffusion tensor cardiovascular magnetic resonance to simultaneously provide biomarkers of microstructure and perfusion in vivo in the human heart. Methods: Here we introduce a novel STEAM-IVIM sequence incorporating phase cycling to obtain true non-diffusion weighted images (b = 0 s/mm2). STEAM-IVIM imaging was performed at 20 b-values (0 to 1000 s/mm2) to enable accurate estimation of the IVIM parameters, and with six diffusion encoding directions to enable reconstruction of the diffusion tensor. 20 healthy subjects (8 female, median age 31 years) were imaged on a clinical 3T system with STEAM-IVIM. A simulation study was performed to investigate the optimal fitting algorithms for the IVIM parameters, which was subsequently used to create pixel-wise IVIM parameter maps for the in vivo acquisitions. Results: Good image quality across the myocardium was obtained for all b-values. Mean(±SD) IVIM parameter estimates were: diffusivity D = 0.83 ± 0.07 × 10-3 mm2/s, perfusion coefficient D* = 19.08 ± 6.48 × 10-3 mm2/s, perfusion fraction f = 19.72 ± 4.11%, and mean diffusion tensor parameters were: mean diffusivity = 0.88 ± 0.06 × 10-3 mm2/s, fractional anisotropy = 0.45 ± 0.04, absolute E2 angle = 55.29 ± 6.38º, helix angle gradient = -0.68 ± 0.18º/%. Conclusion: Phase-cycled STEAM-IVIM enables fitting of cardiac diffusion tensor and perfusion parameters in healthy subjects and shows promise for the simultaneous detection of microstructural aberration and perfusion abnormalities in the presence of cardiac disease without the need for exogenous contrast agents.http://www.sciencedirect.com/science/article/pii/S1097664724011566Diffusion tensor CMRIntravoxel incoherent motionCardiac microstructureMyocardial perfusion |
| spellingShingle | Camila Munoz Eunji Lim Pedro F. Ferreira Dudley J. Pennell Sonia Nielles-Vallespin Andrew D. Scott Simultaneous non-contrast assessment of cardiac microstructure and perfusion in vivo in the human heart Journal of Cardiovascular Magnetic Resonance Diffusion tensor CMR Intravoxel incoherent motion Cardiac microstructure Myocardial perfusion |
| title | Simultaneous non-contrast assessment of cardiac microstructure and perfusion in vivo in the human heart |
| title_full | Simultaneous non-contrast assessment of cardiac microstructure and perfusion in vivo in the human heart |
| title_fullStr | Simultaneous non-contrast assessment of cardiac microstructure and perfusion in vivo in the human heart |
| title_full_unstemmed | Simultaneous non-contrast assessment of cardiac microstructure and perfusion in vivo in the human heart |
| title_short | Simultaneous non-contrast assessment of cardiac microstructure and perfusion in vivo in the human heart |
| title_sort | simultaneous non contrast assessment of cardiac microstructure and perfusion in vivo in the human heart |
| topic | Diffusion tensor CMR Intravoxel incoherent motion Cardiac microstructure Myocardial perfusion |
| url | http://www.sciencedirect.com/science/article/pii/S1097664724011566 |
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