Doxycycline Proniosomal Gel as Local Drug Delivery System in Periodontal Disease: A Vitro Study
Background: Periodontitis is an inflammatory condition of the oral cavity in which microorganisms play a significant role in the pathogenesis and onset. The host immune system starts as an inflammatory process in response to microbial attack that protects and kills the periodontium. Doxycycline is a...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
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| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_726_24 |
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| author | Dhawal Rajendra Mody Vrushali Lathiya Abhay P. Kolte Vaishnavi Biradar Vaishnavi Langde |
| author_facet | Dhawal Rajendra Mody Vrushali Lathiya Abhay P. Kolte Vaishnavi Biradar Vaishnavi Langde |
| author_sort | Dhawal Rajendra Mody |
| collection | DOAJ |
| description | Background:
Periodontitis is an inflammatory condition of the oral cavity in which microorganisms play a significant role in the pathogenesis and onset. The host immune system starts as an inflammatory process in response to microbial attack that protects and kills the periodontium. Doxycycline is a semi-synthetic variant of tetracycline that is made from oxytetracycline. Doxycycline inhibits the production of both aerobic and anaerobic microbial protein through its potent activity against both Gram-positive and Gram-negative bacteria.
Materials and Methods:
The preparation method of doxycycline proniosomal gel involved accurately weighing doxycycline and all excipients (12 Batches). Doxycycline was mixed with 1 ml of ethanol, and all the excipients, like surfactant, lecithin, cholesterol, were added in precisely weighed amounts. The characterization of proniosomal gel and determination of drug entrapment efficacy is calculated.
Result:
Doxycycline release from the doxycycline proniosomal gel (Batch F12) was studied using Franz diffusion cell assembly with dialysis membrane for 7 days in phosphate-buffered saline (7.4) indicated sustained release of doxycycline from the formulation.
Conclusion:
Proniosome containing doxycycline may therefore be a locally effective drug delivery method for treating periodontitis. Current in vitro study is mainly focused on preparation of proniosomal gel containing doxycycline as local drug delivery system in periodontal disease. |
| format | Article |
| id | doaj-art-37b1c222594e4528a4100cfcbdde9eaf |
| institution | Kabale University |
| issn | 0976-4879 0975-7406 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj-art-37b1c222594e4528a4100cfcbdde9eaf2025-01-12T14:11:56ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062024-12-0116Suppl 4S3227S322910.4103/jpbs.jpbs_726_24Doxycycline Proniosomal Gel as Local Drug Delivery System in Periodontal Disease: A Vitro StudyDhawal Rajendra ModyVrushali LathiyaAbhay P. KolteVaishnavi BiradarVaishnavi LangdeBackground: Periodontitis is an inflammatory condition of the oral cavity in which microorganisms play a significant role in the pathogenesis and onset. The host immune system starts as an inflammatory process in response to microbial attack that protects and kills the periodontium. Doxycycline is a semi-synthetic variant of tetracycline that is made from oxytetracycline. Doxycycline inhibits the production of both aerobic and anaerobic microbial protein through its potent activity against both Gram-positive and Gram-negative bacteria. Materials and Methods: The preparation method of doxycycline proniosomal gel involved accurately weighing doxycycline and all excipients (12 Batches). Doxycycline was mixed with 1 ml of ethanol, and all the excipients, like surfactant, lecithin, cholesterol, were added in precisely weighed amounts. The characterization of proniosomal gel and determination of drug entrapment efficacy is calculated. Result: Doxycycline release from the doxycycline proniosomal gel (Batch F12) was studied using Franz diffusion cell assembly with dialysis membrane for 7 days in phosphate-buffered saline (7.4) indicated sustained release of doxycycline from the formulation. Conclusion: Proniosome containing doxycycline may therefore be a locally effective drug delivery method for treating periodontitis. Current in vitro study is mainly focused on preparation of proniosomal gel containing doxycycline as local drug delivery system in periodontal disease.https://journals.lww.com/10.4103/jpbs.jpbs_726_24doxycyclinelocal drug deliveryperiodontitisproniosome |
| spellingShingle | Dhawal Rajendra Mody Vrushali Lathiya Abhay P. Kolte Vaishnavi Biradar Vaishnavi Langde Doxycycline Proniosomal Gel as Local Drug Delivery System in Periodontal Disease: A Vitro Study Journal of Pharmacy and Bioallied Sciences doxycycline local drug delivery periodontitis proniosome |
| title | Doxycycline Proniosomal Gel as Local Drug Delivery System in Periodontal Disease: A Vitro Study |
| title_full | Doxycycline Proniosomal Gel as Local Drug Delivery System in Periodontal Disease: A Vitro Study |
| title_fullStr | Doxycycline Proniosomal Gel as Local Drug Delivery System in Periodontal Disease: A Vitro Study |
| title_full_unstemmed | Doxycycline Proniosomal Gel as Local Drug Delivery System in Periodontal Disease: A Vitro Study |
| title_short | Doxycycline Proniosomal Gel as Local Drug Delivery System in Periodontal Disease: A Vitro Study |
| title_sort | doxycycline proniosomal gel as local drug delivery system in periodontal disease a vitro study |
| topic | doxycycline local drug delivery periodontitis proniosome |
| url | https://journals.lww.com/10.4103/jpbs.jpbs_726_24 |
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