Osseoconductive CaTi<sub>4-z</sub>Zr<sub>z</sub>(PO<sub>4</sub>)<sub>6</sub> Ceramics: Solutions Towards Nonunion, Osteoporosis, and Osteoarthrosis Conditions?
Transition (Ti, Zr) metal-substituted calcium hexaorthophosphate CaTi<sub>4-z</sub>Zr<sub>z</sub>(PO<sub>4</sub>)<sub>6</sub> coatings with an NaSICon structure were deposited by atmospheric plasma spraying (APS) onto Ti6Al4Veli substrates using a stat...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
|
| Series: | Ceramics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2571-6131/7/4/122 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846105338295615488 |
|---|---|
| author | Robert B. Heimann |
| author_facet | Robert B. Heimann |
| author_sort | Robert B. Heimann |
| collection | DOAJ |
| description | Transition (Ti, Zr) metal-substituted calcium hexaorthophosphate CaTi<sub>4-z</sub>Zr<sub>z</sub>(PO<sub>4</sub>)<sub>6</sub> coatings with an NaSICon structure were deposited by atmospheric plasma spraying (APS) onto Ti6Al4Veli substrates using a statistical design of experiments (SDE) methodology. Several coating properties were determined, including chemical composition, porosity, surface roughness, tensile adhesion strength, shear strength, and solubility in protein-free simulated body fluid (pf-SBF) and TRIS-HCl buffer solution. The biological performance evaluation involved cell proliferation and vitality studies and osseointegration tests of coated Ti6Al4Veli rods intramedullary implanted in sheep femora. After a 6 months observation time, a satisfactory gap-bridging potential was apparent as shown by a continuous, well-adhering layer of newly formed cortical bone. These tests suggest that the coatings possess a suitable osseoconductive potential and present an enhanced expression of bone growth-supporting non-collagenous proteins and cytokines, a high cell proliferation, spreading and vitality, and substantial osseointegration by strong bone apposition. The moderate intrinsic ionic conductivity of CaTi<sub>4-z</sub>Zr<sub>z</sub>(PO<sub>4</sub>)<sub>6</sub> compounds can be augmented by doping with highly mobile Na<sup>+</sup> or Li<sup>+</sup> ions to levels that suggest their use in electric bone growth stimulation (EBGS) devices, able to treat nonunion (pseudoarthrosis) and osteoporosis, and that may also support spinal stabilisation by vertebral fusion. |
| format | Article |
| id | doaj-art-37a7edfa36954fa3af493430253c39c7 |
| institution | Kabale University |
| issn | 2571-6131 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Ceramics |
| spelling | doaj-art-37a7edfa36954fa3af493430253c39c72024-12-27T14:16:50ZengMDPI AGCeramics2571-61312024-12-01741964198110.3390/ceramics7040122Osseoconductive CaTi<sub>4-z</sub>Zr<sub>z</sub>(PO<sub>4</sub>)<sub>6</sub> Ceramics: Solutions Towards Nonunion, Osteoporosis, and Osteoarthrosis Conditions?Robert B. Heimann0Independent Researcher, Am Stadtpark 2A, D-02826 Görlitz, GermanyTransition (Ti, Zr) metal-substituted calcium hexaorthophosphate CaTi<sub>4-z</sub>Zr<sub>z</sub>(PO<sub>4</sub>)<sub>6</sub> coatings with an NaSICon structure were deposited by atmospheric plasma spraying (APS) onto Ti6Al4Veli substrates using a statistical design of experiments (SDE) methodology. Several coating properties were determined, including chemical composition, porosity, surface roughness, tensile adhesion strength, shear strength, and solubility in protein-free simulated body fluid (pf-SBF) and TRIS-HCl buffer solution. The biological performance evaluation involved cell proliferation and vitality studies and osseointegration tests of coated Ti6Al4Veli rods intramedullary implanted in sheep femora. After a 6 months observation time, a satisfactory gap-bridging potential was apparent as shown by a continuous, well-adhering layer of newly formed cortical bone. These tests suggest that the coatings possess a suitable osseoconductive potential and present an enhanced expression of bone growth-supporting non-collagenous proteins and cytokines, a high cell proliferation, spreading and vitality, and substantial osseointegration by strong bone apposition. The moderate intrinsic ionic conductivity of CaTi<sub>4-z</sub>Zr<sub>z</sub>(PO<sub>4</sub>)<sub>6</sub> compounds can be augmented by doping with highly mobile Na<sup>+</sup> or Li<sup>+</sup> ions to levels that suggest their use in electric bone growth stimulation (EBGS) devices, able to treat nonunion (pseudoarthrosis) and osteoporosis, and that may also support spinal stabilisation by vertebral fusion.https://www.mdpi.com/2571-6131/7/4/122CaTi<sub>4-z</sub>Zr<sub>z</sub>(PO<sub>4</sub>)<sub>6</sub> coatingsthermal stabilitythermal expansioncompressive stresssolubilityionic conductivity |
| spellingShingle | Robert B. Heimann Osseoconductive CaTi<sub>4-z</sub>Zr<sub>z</sub>(PO<sub>4</sub>)<sub>6</sub> Ceramics: Solutions Towards Nonunion, Osteoporosis, and Osteoarthrosis Conditions? Ceramics CaTi<sub>4-z</sub>Zr<sub>z</sub>(PO<sub>4</sub>)<sub>6</sub> coatings thermal stability thermal expansion compressive stress solubility ionic conductivity |
| title | Osseoconductive CaTi<sub>4-z</sub>Zr<sub>z</sub>(PO<sub>4</sub>)<sub>6</sub> Ceramics: Solutions Towards Nonunion, Osteoporosis, and Osteoarthrosis Conditions? |
| title_full | Osseoconductive CaTi<sub>4-z</sub>Zr<sub>z</sub>(PO<sub>4</sub>)<sub>6</sub> Ceramics: Solutions Towards Nonunion, Osteoporosis, and Osteoarthrosis Conditions? |
| title_fullStr | Osseoconductive CaTi<sub>4-z</sub>Zr<sub>z</sub>(PO<sub>4</sub>)<sub>6</sub> Ceramics: Solutions Towards Nonunion, Osteoporosis, and Osteoarthrosis Conditions? |
| title_full_unstemmed | Osseoconductive CaTi<sub>4-z</sub>Zr<sub>z</sub>(PO<sub>4</sub>)<sub>6</sub> Ceramics: Solutions Towards Nonunion, Osteoporosis, and Osteoarthrosis Conditions? |
| title_short | Osseoconductive CaTi<sub>4-z</sub>Zr<sub>z</sub>(PO<sub>4</sub>)<sub>6</sub> Ceramics: Solutions Towards Nonunion, Osteoporosis, and Osteoarthrosis Conditions? |
| title_sort | osseoconductive cati sub 4 z sub zr sub z sub po sub 4 sub sub 6 sub ceramics solutions towards nonunion osteoporosis and osteoarthrosis conditions |
| topic | CaTi<sub>4-z</sub>Zr<sub>z</sub>(PO<sub>4</sub>)<sub>6</sub> coatings thermal stability thermal expansion compressive stress solubility ionic conductivity |
| url | https://www.mdpi.com/2571-6131/7/4/122 |
| work_keys_str_mv | AT robertbheimann osseoconductivecatisub4zsubzrsubzsubposub4subsub6subceramicssolutionstowardsnonunionosteoporosisandosteoarthrosisconditions |