Coronary CT angiography: First comparison of model-based and hybrid iterative reconstruction with the reference standard invasive catheter angiography for CAD-RADS reporting
Background: The purpose of this study was to compare CCTA images generated using HIR and IMR algorithm with the reference standard ICA, and to determine to what extend further improvements of IMR over HIR can be expected. Methods: This retrospective study included 60 patients with low to intermediat...
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Elsevier
2024-12-01
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| Series: | European Journal of Radiology Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352047724000674 |
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| author | Aiste Matuleviciute-Stojanoska Julia Sautier Verena Bauer Martin Nuessel Volha Nizhnikava Christian Stumpf Thorsten Klink |
| author_facet | Aiste Matuleviciute-Stojanoska Julia Sautier Verena Bauer Martin Nuessel Volha Nizhnikava Christian Stumpf Thorsten Klink |
| author_sort | Aiste Matuleviciute-Stojanoska |
| collection | DOAJ |
| description | Background: The purpose of this study was to compare CCTA images generated using HIR and IMR algorithm with the reference standard ICA, and to determine to what extend further improvements of IMR over HIR can be expected. Methods: This retrospective study included 60 patients with low to intermediate CAD risk, who underwent coronary CTA (with HIR and IMR) and ICA. ICA was used as reference standard. Two independent and blinded readers evaluated 2226 segments, classifying stenosis with CAD-RADS (significant stenosis ≥3). Image quality was assessed with a 5-point scale, SNR in the ascending aorta, and FWHM of proximal LCA calibers. The impact of image noise, radiation dose, and BMI on diagnostic accuracy was evaluated using ROC curves and Fisher’s Exact Test. Quantitative plaque analysis was performed on 28 plaques. Results: IMR showed higher image quality than HIR (IMR 4.4, HIR 3.97, p<0.001) with better SNR (21.4 vs. 13.28, p<0.001) and FWHM (4.44 vs. 4.55, p=0.003). IMR had better diagnostic accuracy (ROC AUC 0.967 vs. 0.948, p=0.16, performed better at higher radiation doses (p=0.02) and showed a larger minimum lumen area (p=0.022 and p=0.046). Conclusion: IMR offers significantly superior image quality of CCTA, more precise measurements, and a stronger positive correlation with ICA. The overall diagnostic accuracy may be superior with IMR, although the differences were not statistically significant. However, in patients who are exposed to higher radiation doses during CCTA due to their constitution, IMR enables significantly better diagnostic accuracy than HIR thus providing a specific benefit for obese patients. |
| format | Article |
| id | doaj-art-379edc61e14247bfab3dce261bbbf6c7 |
| institution | Kabale University |
| issn | 2352-0477 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | European Journal of Radiology Open |
| spelling | doaj-art-379edc61e14247bfab3dce261bbbf6c72024-12-15T06:15:50ZengElsevierEuropean Journal of Radiology Open2352-04772024-12-0113100612Coronary CT angiography: First comparison of model-based and hybrid iterative reconstruction with the reference standard invasive catheter angiography for CAD-RADS reportingAiste Matuleviciute-Stojanoska0Julia Sautier1Verena Bauer2Martin Nuessel3Volha Nizhnikava4Christian Stumpf5Thorsten Klink6Institute of Diagnostic and Interventional Radiology, Klinikum Bayreuth, Medical Campus Oberfranken, Friedrich Alexander University Erlangen, Bayreuth, Germany; Correspondence to: Institute of Diagnostic and Interventional Radiology, Klinikum Bayreuth, Medical Campus Oberfranken, Friedrich-Alexander University Erlangen, Preuschwitzer Str. 10, Bayreuth, Bavaria 95445, Germany.Institute of Diagnostic and Interventional Radiology, Klinikum Bayreuth, Medical Campus Oberfranken, Friedrich Alexander University Erlangen, Bayreuth, GermanyDepartment of Cardiology, Klinikum Bayreuth, Medical Campus Oberfranken, Friedrich Alexander University Erlangen, Bayreuth, GermanyInstitute of Diagnostic and Interventional Radiology, Klinikum Bayreuth, Medical Campus Oberfranken, Friedrich Alexander University Erlangen, Bayreuth, GermanyDepartment of Radiology, Kantonsspital Graubuenden, Chur, SwitzerlandDepartment of Cardiology, Klinikum Bayreuth, Medical Campus Oberfranken, Friedrich Alexander University Erlangen, Bayreuth, GermanyInstitute of Diagnostic and Interventional Radiology, Klinikum Bayreuth, Medical Campus Oberfranken, Friedrich Alexander University Erlangen, Bayreuth, GermanyBackground: The purpose of this study was to compare CCTA images generated using HIR and IMR algorithm with the reference standard ICA, and to determine to what extend further improvements of IMR over HIR can be expected. Methods: This retrospective study included 60 patients with low to intermediate CAD risk, who underwent coronary CTA (with HIR and IMR) and ICA. ICA was used as reference standard. Two independent and blinded readers evaluated 2226 segments, classifying stenosis with CAD-RADS (significant stenosis ≥3). Image quality was assessed with a 5-point scale, SNR in the ascending aorta, and FWHM of proximal LCA calibers. The impact of image noise, radiation dose, and BMI on diagnostic accuracy was evaluated using ROC curves and Fisher’s Exact Test. Quantitative plaque analysis was performed on 28 plaques. Results: IMR showed higher image quality than HIR (IMR 4.4, HIR 3.97, p<0.001) with better SNR (21.4 vs. 13.28, p<0.001) and FWHM (4.44 vs. 4.55, p=0.003). IMR had better diagnostic accuracy (ROC AUC 0.967 vs. 0.948, p=0.16, performed better at higher radiation doses (p=0.02) and showed a larger minimum lumen area (p=0.022 and p=0.046). Conclusion: IMR offers significantly superior image quality of CCTA, more precise measurements, and a stronger positive correlation with ICA. The overall diagnostic accuracy may be superior with IMR, although the differences were not statistically significant. However, in patients who are exposed to higher radiation doses during CCTA due to their constitution, IMR enables significantly better diagnostic accuracy than HIR thus providing a specific benefit for obese patients.http://www.sciencedirect.com/science/article/pii/S2352047724000674Coronary CTAIterative model-based reconstruction (IMR)Hybrid iterative reconstruction (HIR)Diagnostic accuracyPlaque analysisObesity |
| spellingShingle | Aiste Matuleviciute-Stojanoska Julia Sautier Verena Bauer Martin Nuessel Volha Nizhnikava Christian Stumpf Thorsten Klink Coronary CT angiography: First comparison of model-based and hybrid iterative reconstruction with the reference standard invasive catheter angiography for CAD-RADS reporting European Journal of Radiology Open Coronary CTA Iterative model-based reconstruction (IMR) Hybrid iterative reconstruction (HIR) Diagnostic accuracy Plaque analysis Obesity |
| title | Coronary CT angiography: First comparison of model-based and hybrid iterative reconstruction with the reference standard invasive catheter angiography for CAD-RADS reporting |
| title_full | Coronary CT angiography: First comparison of model-based and hybrid iterative reconstruction with the reference standard invasive catheter angiography for CAD-RADS reporting |
| title_fullStr | Coronary CT angiography: First comparison of model-based and hybrid iterative reconstruction with the reference standard invasive catheter angiography for CAD-RADS reporting |
| title_full_unstemmed | Coronary CT angiography: First comparison of model-based and hybrid iterative reconstruction with the reference standard invasive catheter angiography for CAD-RADS reporting |
| title_short | Coronary CT angiography: First comparison of model-based and hybrid iterative reconstruction with the reference standard invasive catheter angiography for CAD-RADS reporting |
| title_sort | coronary ct angiography first comparison of model based and hybrid iterative reconstruction with the reference standard invasive catheter angiography for cad rads reporting |
| topic | Coronary CTA Iterative model-based reconstruction (IMR) Hybrid iterative reconstruction (HIR) Diagnostic accuracy Plaque analysis Obesity |
| url | http://www.sciencedirect.com/science/article/pii/S2352047724000674 |
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