CXCL13 as a Biomarker: Background and Utility in Multiple Sclerosis
CXCL13 is a chemokine which is upregulated within the CNS in multiple sclerosis, Lyme neuroborreliosis, and other inflammatory diseases and is increasingly clinically useful as a biomarker. This review provides background for understanding its function in the immune system and its relationship to ec...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-11-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/14/12/1541 |
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| _version_ | 1846105553165615104 |
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| author | Andrew R. Pachner Steven Pike Andrew D. Smith Francesca Gilli |
| author_facet | Andrew R. Pachner Steven Pike Andrew D. Smith Francesca Gilli |
| author_sort | Andrew R. Pachner |
| collection | DOAJ |
| description | CXCL13 is a chemokine which is upregulated within the CNS in multiple sclerosis, Lyme neuroborreliosis, and other inflammatory diseases and is increasingly clinically useful as a biomarker. This review provides background for understanding its function in the immune system and its relationship to ectopic lymphoid follicles. Also reviewed are its utility in multiple sclerosis and Lyme neuroborreliosis and potential problems in its measurement. CXCL13 has the potential to be an exceptionally useful biomarker in a range of inflammatory diseases. |
| format | Article |
| id | doaj-art-3790e866b1b749309894bca6cde2b6e5 |
| institution | Kabale University |
| issn | 2218-273X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-3790e866b1b749309894bca6cde2b6e52024-12-27T14:13:44ZengMDPI AGBiomolecules2218-273X2024-11-011412154110.3390/biom14121541CXCL13 as a Biomarker: Background and Utility in Multiple SclerosisAndrew R. Pachner0Steven Pike1Andrew D. Smith2Francesca Gilli3Geisel School of Medicine at Dartmouth, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USAGeisel School of Medicine at Dartmouth, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USAGeisel School of Medicine at Dartmouth, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USAGeisel School of Medicine at Dartmouth, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USACXCL13 is a chemokine which is upregulated within the CNS in multiple sclerosis, Lyme neuroborreliosis, and other inflammatory diseases and is increasingly clinically useful as a biomarker. This review provides background for understanding its function in the immune system and its relationship to ectopic lymphoid follicles. Also reviewed are its utility in multiple sclerosis and Lyme neuroborreliosis and potential problems in its measurement. CXCL13 has the potential to be an exceptionally useful biomarker in a range of inflammatory diseases.https://www.mdpi.com/2218-273X/14/12/1541chemokinechemoattractantCXCL13multiple sclerosisLyme neuroborreliosisectopic lymphoid follicle |
| spellingShingle | Andrew R. Pachner Steven Pike Andrew D. Smith Francesca Gilli CXCL13 as a Biomarker: Background and Utility in Multiple Sclerosis Biomolecules chemokine chemoattractant CXCL13 multiple sclerosis Lyme neuroborreliosis ectopic lymphoid follicle |
| title | CXCL13 as a Biomarker: Background and Utility in Multiple Sclerosis |
| title_full | CXCL13 as a Biomarker: Background and Utility in Multiple Sclerosis |
| title_fullStr | CXCL13 as a Biomarker: Background and Utility in Multiple Sclerosis |
| title_full_unstemmed | CXCL13 as a Biomarker: Background and Utility in Multiple Sclerosis |
| title_short | CXCL13 as a Biomarker: Background and Utility in Multiple Sclerosis |
| title_sort | cxcl13 as a biomarker background and utility in multiple sclerosis |
| topic | chemokine chemoattractant CXCL13 multiple sclerosis Lyme neuroborreliosis ectopic lymphoid follicle |
| url | https://www.mdpi.com/2218-273X/14/12/1541 |
| work_keys_str_mv | AT andrewrpachner cxcl13asabiomarkerbackgroundandutilityinmultiplesclerosis AT stevenpike cxcl13asabiomarkerbackgroundandutilityinmultiplesclerosis AT andrewdsmith cxcl13asabiomarkerbackgroundandutilityinmultiplesclerosis AT francescagilli cxcl13asabiomarkerbackgroundandutilityinmultiplesclerosis |