Exploring the mechanism of action of Rosa roxburghii Tratt quercetin in ameliorating type 2 diabetes in mice based on the intestinal microbiome and metabolomics
The aim of this study was to evaluate the effect of Rosa roxburghii Tratt (RRT) quercetin on type 2 diabetes mellitus (T2DM). A high-sugar and high-fat diet combined with streptozotocin (STZ) was used to construct a mouse model of T2DM. In this study, level of blood glucose, lipid and inflammatory f...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464624006431 |
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| author | Ziyi Zhao Yuping Zhu Lu Nie Yisha Luo Shuyi Qiu Tingyuan Ren |
| author_facet | Ziyi Zhao Yuping Zhu Lu Nie Yisha Luo Shuyi Qiu Tingyuan Ren |
| author_sort | Ziyi Zhao |
| collection | DOAJ |
| description | The aim of this study was to evaluate the effect of Rosa roxburghii Tratt (RRT) quercetin on type 2 diabetes mellitus (T2DM). A high-sugar and high-fat diet combined with streptozotocin (STZ) was used to construct a mouse model of T2DM. In this study, level of blood glucose, lipid and inflammatory factors, surface area of the cecum wall, pH and free ammonia, histopathology, and the composition of the intestinal microbiota and metabolites were analyzed. After 28 days of intervention, RRT quercetin significantly (p < 0.05) improved these indicators and ameliorated liver and intestinal damage. And RRT quercetin modulated the relative abundance of harmful and probiotic bacterial genera, and the levels of the differentially abundant metabolites biliverdin, L-homophenylalanine and dihydrofolic acid. The results showed that RRT quercetin could improve insulin resistance, dyslipidemia and the body inflammatory response due to T2DM by regulating the intestinal microenvironment, intestinal flora composition and metabolite levels. |
| format | Article |
| id | doaj-art-3789e8e2c4384b0c8abf22f300b4c97e |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-3789e8e2c4384b0c8abf22f300b4c97e2025-01-12T05:24:45ZengElsevierJournal of Functional Foods1756-46462025-01-01124106640Exploring the mechanism of action of Rosa roxburghii Tratt quercetin in ameliorating type 2 diabetes in mice based on the intestinal microbiome and metabolomicsZiyi Zhao0Yuping Zhu1Lu Nie2Yisha Luo3Shuyi Qiu4Tingyuan Ren5School of Liquor and Food Engineering, Guizhou University, Guiyang 55025, ChinaSchool of Basic Medicine, Guizhou Medical University, Guiyang 561113, ChinaSchool of Liquor and Food Engineering, Guizhou University, Guiyang 55025, ChinaSchool of Liquor and Food Engineering, Guizhou University, Guiyang 55025, ChinaSchool of Liquor and Food Engineering, Guizhou University, Guiyang 55025, ChinaSchool of Liquor and Food Engineering, Guizhou University, Guiyang 55025, China; Corresponding author.The aim of this study was to evaluate the effect of Rosa roxburghii Tratt (RRT) quercetin on type 2 diabetes mellitus (T2DM). A high-sugar and high-fat diet combined with streptozotocin (STZ) was used to construct a mouse model of T2DM. In this study, level of blood glucose, lipid and inflammatory factors, surface area of the cecum wall, pH and free ammonia, histopathology, and the composition of the intestinal microbiota and metabolites were analyzed. After 28 days of intervention, RRT quercetin significantly (p < 0.05) improved these indicators and ameliorated liver and intestinal damage. And RRT quercetin modulated the relative abundance of harmful and probiotic bacterial genera, and the levels of the differentially abundant metabolites biliverdin, L-homophenylalanine and dihydrofolic acid. The results showed that RRT quercetin could improve insulin resistance, dyslipidemia and the body inflammatory response due to T2DM by regulating the intestinal microenvironment, intestinal flora composition and metabolite levels.http://www.sciencedirect.com/science/article/pii/S1756464624006431Rosa roxburghii Tratt quercetinType 2 diabetes mellitusGut microbiomeMetabolomics |
| spellingShingle | Ziyi Zhao Yuping Zhu Lu Nie Yisha Luo Shuyi Qiu Tingyuan Ren Exploring the mechanism of action of Rosa roxburghii Tratt quercetin in ameliorating type 2 diabetes in mice based on the intestinal microbiome and metabolomics Journal of Functional Foods Rosa roxburghii Tratt quercetin Type 2 diabetes mellitus Gut microbiome Metabolomics |
| title | Exploring the mechanism of action of Rosa roxburghii Tratt quercetin in ameliorating type 2 diabetes in mice based on the intestinal microbiome and metabolomics |
| title_full | Exploring the mechanism of action of Rosa roxburghii Tratt quercetin in ameliorating type 2 diabetes in mice based on the intestinal microbiome and metabolomics |
| title_fullStr | Exploring the mechanism of action of Rosa roxburghii Tratt quercetin in ameliorating type 2 diabetes in mice based on the intestinal microbiome and metabolomics |
| title_full_unstemmed | Exploring the mechanism of action of Rosa roxburghii Tratt quercetin in ameliorating type 2 diabetes in mice based on the intestinal microbiome and metabolomics |
| title_short | Exploring the mechanism of action of Rosa roxburghii Tratt quercetin in ameliorating type 2 diabetes in mice based on the intestinal microbiome and metabolomics |
| title_sort | exploring the mechanism of action of rosa roxburghii tratt quercetin in ameliorating type 2 diabetes in mice based on the intestinal microbiome and metabolomics |
| topic | Rosa roxburghii Tratt quercetin Type 2 diabetes mellitus Gut microbiome Metabolomics |
| url | http://www.sciencedirect.com/science/article/pii/S1756464624006431 |
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