Functional Role of miR-499a-5p in the Development of Gastric Cancer
Background/Aims: Gastric cancer (GC) is a highly prone malignant tumor, which has attracted wide attention. This study investigated the expression and clinical value of miR-499a-5p in GC. Materials and Methods: A total of 105 patients with GC were included in this study. Simultaneously, 55 patien...
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| Format: | Article |
| Language: | English |
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AVES
2025-01-01
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| Series: | The Turkish Journal of Gastroenterology |
| Online Access: | https://www.turkjgastroenterol.org/en/functional-role-of-mir-499a-5p-in-the-development-of-gastric-cancer-137305 |
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| _version_ | 1841549914781253632 |
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| author | Cuiling Lu Chengwang Guo Cuihua Wu Liping Zhang Xiaoling Liu Shoucun Guo |
| author_facet | Cuiling Lu Chengwang Guo Cuihua Wu Liping Zhang Xiaoling Liu Shoucun Guo |
| author_sort | Cuiling Lu |
| collection | DOAJ |
| description | Background/Aims: Gastric cancer (GC) is a highly prone malignant tumor, which has attracted wide attention. This study investigated the expression and clinical value of miR-499a-5p in GC.
Materials and Methods: A total of 105 patients with GC were included in this study. Simultaneously, 55 patients with benign stomach disorders and 45 healthy subjects were enrolled as controls. Real-time quantitative polymerase chain reaction was used to determine the expression of miR-499a-5p. The receiver operating characteristic curve was used to assess the diagnostic value of miR-499a-5p in GC. Kaplan–Meier and logistic analyses were used to evaluate the association between miR-499a-5p and GC prognosis.
Results: The levels of miR-499a-5p are markedly downregulated in GC and have a high diagnostic value. miR-499a-5p is closely linked to pathological features of GC. Overexpression of miR-499a-5p inhibits GC cell growth, migration, and invasion. Furthermore, miR499a-5p is also related to GC and 5-year survival, and is a risk factor for GC death.
Conclusion: The levels of miR-499a-5p were markedly downregulated in GC and related to GC pathological features. It has the potential to become a biomarker for the diagnosis of GC. |
| format | Article |
| id | doaj-art-3778aca657da482687ab208685c91fc1 |
| institution | Kabale University |
| issn | 2148-5607 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | AVES |
| record_format | Article |
| series | The Turkish Journal of Gastroenterology |
| spelling | doaj-art-3778aca657da482687ab208685c91fc12025-01-10T11:30:31ZengAVESThe Turkish Journal of Gastroenterology2148-56072025-01-01361455210.5152/tjg.2024.24429Functional Role of miR-499a-5p in the Development of Gastric CancerCuiling Lu0Chengwang Guo1Cuihua Wu2Liping Zhang3Xiaoling Liu4Shoucun Guo5Digestive Endoscopy Center, Gansu Wuwei Tumour Hospital, Wuwei, ChinaDepartment of Gastrosurgery, Gansu Wuwei Tumour Hospital, Wuwei, ChinaDigestive Endoscopy Center, Gansu Wuwei Tumour Hospital, Wuwei, ChinaDigestive Endoscopy Center, Gansu Wuwei Tumour Hospital, Wuwei, ChinaDigestive Endoscopy Center, Gansu Wuwei Tumour Hospital, Wuwei, ChinaDigestive Endoscopy Center, Gansu Wuwei Tumour Hospital, Wuwei, ChinaBackground/Aims: Gastric cancer (GC) is a highly prone malignant tumor, which has attracted wide attention. This study investigated the expression and clinical value of miR-499a-5p in GC. Materials and Methods: A total of 105 patients with GC were included in this study. Simultaneously, 55 patients with benign stomach disorders and 45 healthy subjects were enrolled as controls. Real-time quantitative polymerase chain reaction was used to determine the expression of miR-499a-5p. The receiver operating characteristic curve was used to assess the diagnostic value of miR-499a-5p in GC. Kaplan–Meier and logistic analyses were used to evaluate the association between miR-499a-5p and GC prognosis. Results: The levels of miR-499a-5p are markedly downregulated in GC and have a high diagnostic value. miR-499a-5p is closely linked to pathological features of GC. Overexpression of miR-499a-5p inhibits GC cell growth, migration, and invasion. Furthermore, miR499a-5p is also related to GC and 5-year survival, and is a risk factor for GC death. Conclusion: The levels of miR-499a-5p were markedly downregulated in GC and related to GC pathological features. It has the potential to become a biomarker for the diagnosis of GC.https://www.turkjgastroenterol.org/en/functional-role-of-mir-499a-5p-in-the-development-of-gastric-cancer-137305 |
| spellingShingle | Cuiling Lu Chengwang Guo Cuihua Wu Liping Zhang Xiaoling Liu Shoucun Guo Functional Role of miR-499a-5p in the Development of Gastric Cancer The Turkish Journal of Gastroenterology |
| title | Functional Role of miR-499a-5p in the Development of Gastric Cancer |
| title_full | Functional Role of miR-499a-5p in the Development of Gastric Cancer |
| title_fullStr | Functional Role of miR-499a-5p in the Development of Gastric Cancer |
| title_full_unstemmed | Functional Role of miR-499a-5p in the Development of Gastric Cancer |
| title_short | Functional Role of miR-499a-5p in the Development of Gastric Cancer |
| title_sort | functional role of mir 499a 5p in the development of gastric cancer |
| url | https://www.turkjgastroenterol.org/en/functional-role-of-mir-499a-5p-in-the-development-of-gastric-cancer-137305 |
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