Functional Role of miR-499a-5p in the Development of Gastric Cancer
Background/Aims: Gastric cancer (GC) is a highly prone malignant tumor, which has attracted wide attention. This study investigated the expression and clinical value of miR-499a-5p in GC. Materials and Methods: A total of 105 patients with GC were included in this study. Simultaneously, 55 patien...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
AVES
2025-01-01
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| Series: | The Turkish Journal of Gastroenterology |
| Online Access: | https://www.turkjgastroenterol.org/en/functional-role-of-mir-499a-5p-in-the-development-of-gastric-cancer-137305 |
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| Summary: | Background/Aims: Gastric cancer (GC) is a highly prone malignant tumor, which has attracted wide attention. This study investigated the expression and clinical value of miR-499a-5p in GC.
Materials and Methods: A total of 105 patients with GC were included in this study. Simultaneously, 55 patients with benign stomach disorders and 45 healthy subjects were enrolled as controls. Real-time quantitative polymerase chain reaction was used to determine the expression of miR-499a-5p. The receiver operating characteristic curve was used to assess the diagnostic value of miR-499a-5p in GC. Kaplan–Meier and logistic analyses were used to evaluate the association between miR-499a-5p and GC prognosis.
Results: The levels of miR-499a-5p are markedly downregulated in GC and have a high diagnostic value. miR-499a-5p is closely linked to pathological features of GC. Overexpression of miR-499a-5p inhibits GC cell growth, migration, and invasion. Furthermore, miR499a-5p is also related to GC and 5-year survival, and is a risk factor for GC death.
Conclusion: The levels of miR-499a-5p were markedly downregulated in GC and related to GC pathological features. It has the potential to become a biomarker for the diagnosis of GC. |
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| ISSN: | 2148-5607 |