Exploring paraptosis as a therapeutic approach in cancer treatment
Abstract A variety of cell death pathways play critical roles in the onset and progression of multiple diseases. Paraptosis, a unique form of programmed cell death, has gained significant attention in recent years. Unlike apoptosis and necrosis, paraptosis is characterized by cytoplasmic vacuolizati...
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| Format: | Article |
| Language: | English |
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BMC
2024-11-01
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| Series: | Journal of Biomedical Science |
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| Online Access: | https://doi.org/10.1186/s12929-024-01089-4 |
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| _version_ | 1846171727062630400 |
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| author | Ling-Chu Chang Shih-Kai Chiang Shuen-Ei Chen Mien-Chie Hung |
| author_facet | Ling-Chu Chang Shih-Kai Chiang Shuen-Ei Chen Mien-Chie Hung |
| author_sort | Ling-Chu Chang |
| collection | DOAJ |
| description | Abstract A variety of cell death pathways play critical roles in the onset and progression of multiple diseases. Paraptosis, a unique form of programmed cell death, has gained significant attention in recent years. Unlike apoptosis and necrosis, paraptosis is characterized by cytoplasmic vacuolization, swelling of the endoplasmic reticulum and mitochondria, and the absence of caspase activation. Numerous natural products, synthetic compounds, and newly launched nanomedicines have been demonstrated to prime cell death through the paraptotic program and may offer novel therapeutic strategies for cancer treatment. This review summarizes recent findings, delineates the intricate network of signaling pathways underlying paraptosis, and discusses the potential therapeutic implications of targeting paraptosis in cancer treatment. The aim of this review is to expand our understanding of this unique cell death process and explore the potential therapeutic implications of targeting paraptosis in cancer treatment. |
| format | Article |
| id | doaj-art-37670cf0f364400fa978c3d53a56fa9f |
| institution | Kabale University |
| issn | 1423-0127 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Biomedical Science |
| spelling | doaj-art-37670cf0f364400fa978c3d53a56fa9f2024-11-10T12:36:18ZengBMCJournal of Biomedical Science1423-01272024-11-0131112310.1186/s12929-024-01089-4Exploring paraptosis as a therapeutic approach in cancer treatmentLing-Chu Chang0Shih-Kai Chiang1Shuen-Ei Chen2Mien-Chie Hung3Center for Molecular Medicine, China Medical University HospitalDepartment of Animal Science, National Chung Hsing UniversityDepartment of Animal Science, National Chung Hsing UniversityCenter for Molecular Medicine, China Medical University HospitalAbstract A variety of cell death pathways play critical roles in the onset and progression of multiple diseases. Paraptosis, a unique form of programmed cell death, has gained significant attention in recent years. Unlike apoptosis and necrosis, paraptosis is characterized by cytoplasmic vacuolization, swelling of the endoplasmic reticulum and mitochondria, and the absence of caspase activation. Numerous natural products, synthetic compounds, and newly launched nanomedicines have been demonstrated to prime cell death through the paraptotic program and may offer novel therapeutic strategies for cancer treatment. This review summarizes recent findings, delineates the intricate network of signaling pathways underlying paraptosis, and discusses the potential therapeutic implications of targeting paraptosis in cancer treatment. The aim of this review is to expand our understanding of this unique cell death process and explore the potential therapeutic implications of targeting paraptosis in cancer treatment.https://doi.org/10.1186/s12929-024-01089-4ParaptosisCancer cellsProteasome inhibitionEndoplasmic reticulum stressMitochondriaIon homeostasis |
| spellingShingle | Ling-Chu Chang Shih-Kai Chiang Shuen-Ei Chen Mien-Chie Hung Exploring paraptosis as a therapeutic approach in cancer treatment Journal of Biomedical Science Paraptosis Cancer cells Proteasome inhibition Endoplasmic reticulum stress Mitochondria Ion homeostasis |
| title | Exploring paraptosis as a therapeutic approach in cancer treatment |
| title_full | Exploring paraptosis as a therapeutic approach in cancer treatment |
| title_fullStr | Exploring paraptosis as a therapeutic approach in cancer treatment |
| title_full_unstemmed | Exploring paraptosis as a therapeutic approach in cancer treatment |
| title_short | Exploring paraptosis as a therapeutic approach in cancer treatment |
| title_sort | exploring paraptosis as a therapeutic approach in cancer treatment |
| topic | Paraptosis Cancer cells Proteasome inhibition Endoplasmic reticulum stress Mitochondria Ion homeostasis |
| url | https://doi.org/10.1186/s12929-024-01089-4 |
| work_keys_str_mv | AT lingchuchang exploringparaptosisasatherapeuticapproachincancertreatment AT shihkaichiang exploringparaptosisasatherapeuticapproachincancertreatment AT shueneichen exploringparaptosisasatherapeuticapproachincancertreatment AT mienchiehung exploringparaptosisasatherapeuticapproachincancertreatment |