Bioimpedance analysis predicts worsening events in outpatients with heart failure and reduced ejection fraction
Abstract Aims Heart failure (HF) with reduced left ventricle ejection fraction (LVEF) is an entity with poor prognosis characterized by decompensations. Bioelectrical impedance analysis (BIA) is used to assess volume overload (VO) and may be useful to identify apparently stable HF outpatients at ris...
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| Format: | Article |
| Language: | English |
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Wiley
2024-12-01
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| Series: | ESC Heart Failure |
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| Online Access: | https://doi.org/10.1002/ehf2.14908 |
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| author | Carlos Rodríguez‐López Jorge Balaguer Germán Ana Venegas Rodríguez Rocío Carda Barrio Hans Paul Gaebelt Slocker Ana María Pello Lázaro Marta López Castillo Bárbara Soler Bonafont Mónica Recio Vázquez Mikel Taibo Urquía María González Piña Emilio González Parra José Tuñón Álvaro Aceña |
| author_facet | Carlos Rodríguez‐López Jorge Balaguer Germán Ana Venegas Rodríguez Rocío Carda Barrio Hans Paul Gaebelt Slocker Ana María Pello Lázaro Marta López Castillo Bárbara Soler Bonafont Mónica Recio Vázquez Mikel Taibo Urquía María González Piña Emilio González Parra José Tuñón Álvaro Aceña |
| author_sort | Carlos Rodríguez‐López |
| collection | DOAJ |
| description | Abstract Aims Heart failure (HF) with reduced left ventricle ejection fraction (LVEF) is an entity with poor prognosis characterized by decompensations. Bioelectrical impedance analysis (BIA) is used to assess volume overload (VO) and may be useful to identify apparently stable HF outpatients at risk of decompensation. The aim of this study is to analyse whether VO assessed by BIA is associated with worsening heart failure (WHF) in stable outpatients with HF and reduced LVEF (HFrEF). Methods and results This is a prospective single‐centre observational study. Consecutive stable HF outpatients with LVEF below 40% underwent BIA, transthoracic echocardiography, blood sampling, and physical examination and were followed up for 3 months. VO was defined as the difference between the measured weight and the dry weight assessed by BIA. Demographic, clinical, anthropometric, echocardiographic, and analytical parameters were recorded. The primary endpoint was WHF, defined by visits to the emergency department for HF or hospitalization for HF. A total of 100 patients were included. The median VO was 0.5 L (interquartile range 0–1.6 L). Eleven patients met the primary endpoint. Univariate binary logistic regression analysis showed that left ventricle filling pressures assessed by E/e′, N‐terminal pro B‐type natriuretic peptide, inferior vena cava dilatation (≥21 mm), signs of congestion, and VO were associated with the primary endpoint. Binary logistic regression multivariate analysis showed that VO was the only independent predictor for the primary endpoint (adjusted OR 2.7; 95% CI 1.30–5.63, P = 0.008). Multivariate Cox regression analysis also showed an adjusted hazard ratio (HR) for VO of 2.03; 95% CI 1.37–3.02, P < 0.001. Receiver‐operating characteristic curve analysis showed an area under the curve for VO of 0.88 (95% CI 0.79–0.97, P < 0.001) with an optimal cut‐off of 1.2 L. Conclusions VO assessed by BIA is independently associated with WHF in stable outpatients with HFrEF at 3 months. |
| format | Article |
| id | doaj-art-374fec9c48964441bcb27b16d0da9ed7 |
| institution | Kabale University |
| issn | 2055-5822 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | ESC Heart Failure |
| spelling | doaj-art-374fec9c48964441bcb27b16d0da9ed72024-12-11T01:57:00ZengWileyESC Heart Failure2055-58222024-12-011163892390010.1002/ehf2.14908Bioimpedance analysis predicts worsening events in outpatients with heart failure and reduced ejection fractionCarlos Rodríguez‐López0Jorge Balaguer Germán1Ana Venegas Rodríguez2Rocío Carda Barrio3Hans Paul Gaebelt Slocker4Ana María Pello Lázaro5Marta López Castillo6Bárbara Soler Bonafont7Mónica Recio Vázquez8Mikel Taibo Urquía9María González Piña10Emilio González Parra11José Tuñón12Álvaro Aceña13Department of Cardiology Fundación Jiménez Díaz University Hospital Madrid SpainDepartment of Cardiology Fundación Jiménez Díaz University Hospital Madrid SpainDepartment of Cardiology Fundación Jiménez Díaz University Hospital Madrid SpainDepartment of Cardiology Fundación Jiménez Díaz University Hospital Madrid SpainDepartment of Cardiology Fundación Jiménez Díaz University Hospital Madrid SpainDepartment of Cardiology Fundación Jiménez Díaz University Hospital Madrid SpainDepartment of Cardiology Fundación Jiménez Díaz University Hospital Madrid SpainDepartment of Internal Medicine Fundación Jiménez Díaz University Hospital Madrid SpainDepartment of Cardiology Fundación Jiménez Díaz University Hospital Madrid SpainDepartment of Cardiology Fundación Jiménez Díaz University Hospital Madrid SpainDepartment of Cardiology Fundación Jiménez Díaz University Hospital Madrid SpainDepartment of Nephrology Fundación Jiménez Díaz University Hospital Madrid SpainDepartment of Cardiology Fundación Jiménez Díaz University Hospital Madrid SpainDepartment of Cardiology Fundación Jiménez Díaz University Hospital Madrid SpainAbstract Aims Heart failure (HF) with reduced left ventricle ejection fraction (LVEF) is an entity with poor prognosis characterized by decompensations. Bioelectrical impedance analysis (BIA) is used to assess volume overload (VO) and may be useful to identify apparently stable HF outpatients at risk of decompensation. The aim of this study is to analyse whether VO assessed by BIA is associated with worsening heart failure (WHF) in stable outpatients with HF and reduced LVEF (HFrEF). Methods and results This is a prospective single‐centre observational study. Consecutive stable HF outpatients with LVEF below 40% underwent BIA, transthoracic echocardiography, blood sampling, and physical examination and were followed up for 3 months. VO was defined as the difference between the measured weight and the dry weight assessed by BIA. Demographic, clinical, anthropometric, echocardiographic, and analytical parameters were recorded. The primary endpoint was WHF, defined by visits to the emergency department for HF or hospitalization for HF. A total of 100 patients were included. The median VO was 0.5 L (interquartile range 0–1.6 L). Eleven patients met the primary endpoint. Univariate binary logistic regression analysis showed that left ventricle filling pressures assessed by E/e′, N‐terminal pro B‐type natriuretic peptide, inferior vena cava dilatation (≥21 mm), signs of congestion, and VO were associated with the primary endpoint. Binary logistic regression multivariate analysis showed that VO was the only independent predictor for the primary endpoint (adjusted OR 2.7; 95% CI 1.30–5.63, P = 0.008). Multivariate Cox regression analysis also showed an adjusted hazard ratio (HR) for VO of 2.03; 95% CI 1.37–3.02, P < 0.001. Receiver‐operating characteristic curve analysis showed an area under the curve for VO of 0.88 (95% CI 0.79–0.97, P < 0.001) with an optimal cut‐off of 1.2 L. Conclusions VO assessed by BIA is independently associated with WHF in stable outpatients with HFrEF at 3 months.https://doi.org/10.1002/ehf2.14908Bioelectrical impedance analysisHeart failureOutpatientsVolume overloadWorsening heart failure |
| spellingShingle | Carlos Rodríguez‐López Jorge Balaguer Germán Ana Venegas Rodríguez Rocío Carda Barrio Hans Paul Gaebelt Slocker Ana María Pello Lázaro Marta López Castillo Bárbara Soler Bonafont Mónica Recio Vázquez Mikel Taibo Urquía María González Piña Emilio González Parra José Tuñón Álvaro Aceña Bioimpedance analysis predicts worsening events in outpatients with heart failure and reduced ejection fraction ESC Heart Failure Bioelectrical impedance analysis Heart failure Outpatients Volume overload Worsening heart failure |
| title | Bioimpedance analysis predicts worsening events in outpatients with heart failure and reduced ejection fraction |
| title_full | Bioimpedance analysis predicts worsening events in outpatients with heart failure and reduced ejection fraction |
| title_fullStr | Bioimpedance analysis predicts worsening events in outpatients with heart failure and reduced ejection fraction |
| title_full_unstemmed | Bioimpedance analysis predicts worsening events in outpatients with heart failure and reduced ejection fraction |
| title_short | Bioimpedance analysis predicts worsening events in outpatients with heart failure and reduced ejection fraction |
| title_sort | bioimpedance analysis predicts worsening events in outpatients with heart failure and reduced ejection fraction |
| topic | Bioelectrical impedance analysis Heart failure Outpatients Volume overload Worsening heart failure |
| url | https://doi.org/10.1002/ehf2.14908 |
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