Successful treatment of AML using non-intensive chemotherapy in Jehovah's Witness patients
Acute myeloid leukemia (AML) patients undergoing induction chemotherapy receive transfusion support to manage severe cytopenias and associated sequelae. Jehovah's Witness (JW) patients typically decline transfusion of most or all blood products. This can lead to exclusion of JW patients from ot...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Leukemia Research Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213048924000670 |
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| author | David Page Daniel Sawler Joseph Brandwein |
| author_facet | David Page Daniel Sawler Joseph Brandwein |
| author_sort | David Page |
| collection | DOAJ |
| description | Acute myeloid leukemia (AML) patients undergoing induction chemotherapy receive transfusion support to manage severe cytopenias and associated sequelae. Jehovah's Witness (JW) patients typically decline transfusion of most or all blood products. This can lead to exclusion of JW patients from otherwise life-saving treatments due to safety concerns. We present two cases demonstrating the successful induction of JW patients without the need for red cell or platelet transfusion support; the first, an older AML patient induced with azacitidine & venetoclax; the second, a patient with acute promyelocytic leukemia induced using arsenic trioxide and all-trans retinoic acid. Both patients required modifications to the induction regimens to accommodate their wishes. These cases support growing evidence that selected JW patients with AML can be successfully treated using appropriate accommodations. |
| format | Article |
| id | doaj-art-374f3669f68c4c4daa58e1907846693f |
| institution | Kabale University |
| issn | 2213-0489 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Leukemia Research Reports |
| spelling | doaj-art-374f3669f68c4c4daa58e1907846693f2024-12-06T05:13:26ZengElsevierLeukemia Research Reports2213-04892024-01-0122100477Successful treatment of AML using non-intensive chemotherapy in Jehovah's Witness patientsDavid Page0Daniel Sawler1Joseph Brandwein2Corresponding author.; Division of Hematology, Department of Medicine, University of Alberta, Edmonton Alberta CanadaDivision of Hematology, Department of Medicine, University of Alberta, Edmonton Alberta CanadaDivision of Hematology, Department of Medicine, University of Alberta, Edmonton Alberta CanadaAcute myeloid leukemia (AML) patients undergoing induction chemotherapy receive transfusion support to manage severe cytopenias and associated sequelae. Jehovah's Witness (JW) patients typically decline transfusion of most or all blood products. This can lead to exclusion of JW patients from otherwise life-saving treatments due to safety concerns. We present two cases demonstrating the successful induction of JW patients without the need for red cell or platelet transfusion support; the first, an older AML patient induced with azacitidine & venetoclax; the second, a patient with acute promyelocytic leukemia induced using arsenic trioxide and all-trans retinoic acid. Both patients required modifications to the induction regimens to accommodate their wishes. These cases support growing evidence that selected JW patients with AML can be successfully treated using appropriate accommodations.http://www.sciencedirect.com/science/article/pii/S2213048924000670Jehovah's WitnessAMLLeukemiaChemotherapyTreatment |
| spellingShingle | David Page Daniel Sawler Joseph Brandwein Successful treatment of AML using non-intensive chemotherapy in Jehovah's Witness patients Leukemia Research Reports Jehovah's Witness AML Leukemia Chemotherapy Treatment |
| title | Successful treatment of AML using non-intensive chemotherapy in Jehovah's Witness patients |
| title_full | Successful treatment of AML using non-intensive chemotherapy in Jehovah's Witness patients |
| title_fullStr | Successful treatment of AML using non-intensive chemotherapy in Jehovah's Witness patients |
| title_full_unstemmed | Successful treatment of AML using non-intensive chemotherapy in Jehovah's Witness patients |
| title_short | Successful treatment of AML using non-intensive chemotherapy in Jehovah's Witness patients |
| title_sort | successful treatment of aml using non intensive chemotherapy in jehovah s witness patients |
| topic | Jehovah's Witness AML Leukemia Chemotherapy Treatment |
| url | http://www.sciencedirect.com/science/article/pii/S2213048924000670 |
| work_keys_str_mv | AT davidpage successfultreatmentofamlusingnonintensivechemotherapyinjehovahswitnesspatients AT danielsawler successfultreatmentofamlusingnonintensivechemotherapyinjehovahswitnesspatients AT josephbrandwein successfultreatmentofamlusingnonintensivechemotherapyinjehovahswitnesspatients |