Associations of diet and lifestyle with new-onset diabetes and major cardiovascular events: The cardiometabolic disease and cancer cohort (4C) study and mendelian randomization
Background and Aim: At present, there is an absence of a widely accepted model for a healthy diet-lifestyle in China. Therefore, this study aims to provide novel evidence for the development of a healthier diet-lifestyle model specifically tailored to the Chinese population. Methods and Results: Ove...
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| Language: | English |
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Elsevier
2025-01-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464624006170 |
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| author | Yue-Yang Zhang Pei-Dong Li Bing-Xue Chen Qin Wan |
| author_facet | Yue-Yang Zhang Pei-Dong Li Bing-Xue Chen Qin Wan |
| author_sort | Yue-Yang Zhang |
| collection | DOAJ |
| description | Background and Aim: At present, there is an absence of a widely accepted model for a healthy diet-lifestyle in China. Therefore, this study aims to provide novel evidence for the development of a healthier diet-lifestyle model specifically tailored to the Chinese population. Methods and Results: Over the 10-year follow-up period of 7612 participants, 545 incident cases of diabetes and 308 incident cases of major cardiovascular events were documented. Cox regression analysis indicated that participants consuming 0–2 servings of milk per week had a reduced risk of diabetes, with a hazard ratio of 0.72 (0.56–0.92). In contrast, coffee consumption was associated with an increased risk of diabetes. Moderate consumption of carbonated drinks and fruit drink was linked to a decreased risk of major cardiovascular events. The RCS analysis and Mendelian randomization analysis yielded largely consistent results. Conclusions: These research findings underscore the crucial role of maintaining appropriate dietary and lifestyle habits for overall health in adults. |
| format | Article |
| id | doaj-art-373f0214a9e04803aee0a16913707598 |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-373f0214a9e04803aee0a169137075982025-01-12T05:24:42ZengElsevierJournal of Functional Foods1756-46462025-01-01124106614Associations of diet and lifestyle with new-onset diabetes and major cardiovascular events: The cardiometabolic disease and cancer cohort (4C) study and mendelian randomizationYue-Yang Zhang0Pei-Dong Li1Bing-Xue Chen2Qin Wan3Department of Endocrinology and Metabolism, Affiliated Hospital of Southwest Medical University, Luzhou 646000, China; Metabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou 646000, China; Sichuan Clinical Research Center for Diabetes and Metabolism, Luzhou 646000, China; Sichuan Clinical Research Center for Nephropathy, Luzhou 646000, China; Cardiovascular and Metabolic Diseases Key Laboratory of Luzhou, Luzhou 646000, ChinaDepartment of Endocrinology and Metabolism, Affiliated Hospital of Southwest Medical University, Luzhou 646000, China; Metabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou 646000, China; Sichuan Clinical Research Center for Diabetes and Metabolism, Luzhou 646000, China; Sichuan Clinical Research Center for Nephropathy, Luzhou 646000, China; Cardiovascular and Metabolic Diseases Key Laboratory of Luzhou, Luzhou 646000, ChinaDepartment of Ultrasound Medicine, Affiliated Hospital of Southwest Medical University, Luzhou 646000, ChinaDepartment of Endocrinology and Metabolism, Affiliated Hospital of Southwest Medical University, Luzhou 646000, China; Metabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou 646000, China; Sichuan Clinical Research Center for Diabetes and Metabolism, Luzhou 646000, China; Sichuan Clinical Research Center for Nephropathy, Luzhou 646000, China; Cardiovascular and Metabolic Diseases Key Laboratory of Luzhou, Luzhou 646000, China; Corresponding author at: Department of Endocrinology and Metabolism, Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.Background and Aim: At present, there is an absence of a widely accepted model for a healthy diet-lifestyle in China. Therefore, this study aims to provide novel evidence for the development of a healthier diet-lifestyle model specifically tailored to the Chinese population. Methods and Results: Over the 10-year follow-up period of 7612 participants, 545 incident cases of diabetes and 308 incident cases of major cardiovascular events were documented. Cox regression analysis indicated that participants consuming 0–2 servings of milk per week had a reduced risk of diabetes, with a hazard ratio of 0.72 (0.56–0.92). In contrast, coffee consumption was associated with an increased risk of diabetes. Moderate consumption of carbonated drinks and fruit drink was linked to a decreased risk of major cardiovascular events. The RCS analysis and Mendelian randomization analysis yielded largely consistent results. Conclusions: These research findings underscore the crucial role of maintaining appropriate dietary and lifestyle habits for overall health in adults.http://www.sciencedirect.com/science/article/pii/S1756464624006170DietLifestyleDiabetesMajor cardiovascular events |
| spellingShingle | Yue-Yang Zhang Pei-Dong Li Bing-Xue Chen Qin Wan Associations of diet and lifestyle with new-onset diabetes and major cardiovascular events: The cardiometabolic disease and cancer cohort (4C) study and mendelian randomization Journal of Functional Foods Diet Lifestyle Diabetes Major cardiovascular events |
| title | Associations of diet and lifestyle with new-onset diabetes and major cardiovascular events: The cardiometabolic disease and cancer cohort (4C) study and mendelian randomization |
| title_full | Associations of diet and lifestyle with new-onset diabetes and major cardiovascular events: The cardiometabolic disease and cancer cohort (4C) study and mendelian randomization |
| title_fullStr | Associations of diet and lifestyle with new-onset diabetes and major cardiovascular events: The cardiometabolic disease and cancer cohort (4C) study and mendelian randomization |
| title_full_unstemmed | Associations of diet and lifestyle with new-onset diabetes and major cardiovascular events: The cardiometabolic disease and cancer cohort (4C) study and mendelian randomization |
| title_short | Associations of diet and lifestyle with new-onset diabetes and major cardiovascular events: The cardiometabolic disease and cancer cohort (4C) study and mendelian randomization |
| title_sort | associations of diet and lifestyle with new onset diabetes and major cardiovascular events the cardiometabolic disease and cancer cohort 4c study and mendelian randomization |
| topic | Diet Lifestyle Diabetes Major cardiovascular events |
| url | http://www.sciencedirect.com/science/article/pii/S1756464624006170 |
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