Primary bronchial leiomyosarcoma: a diagnostic challenge
Abstract Background Pulmonary bronchial leiomyosarcoma is an extremely rare malignant tumour of the lung originating from the mesenchymal tissue. The retroperitoneal region is the most common site of leiomyosarcoma. It exhibits a high degree of malignancy and a poor prognosis, thereby highlighting t...
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2025-01-01
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| Series: | BMC Pulmonary Medicine |
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| Online Access: | https://doi.org/10.1186/s12890-024-03472-1 |
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| author | Dan Chen Shuai Luo |
| author_facet | Dan Chen Shuai Luo |
| author_sort | Dan Chen |
| collection | DOAJ |
| description | Abstract Background Pulmonary bronchial leiomyosarcoma is an extremely rare malignant tumour of the lung originating from the mesenchymal tissue. The retroperitoneal region is the most common site of leiomyosarcoma. It exhibits a high degree of malignancy and a poor prognosis, thereby highlighting the significance of early diagnosis of this disease. Case demonstration A 61-year-old male with a smoking history of 40 + years was admitted to the hospital due to cough, expectoration, and shortness of breath that extended for half a year, which aggravated for two months and was succeeded by intermittent bloody sputum for one month. Chest computed tomography (CT) revealed a mass in the upper lobe of the right lung, which was identified as a malignant tumour lesion involving the upper thoracic oesophagus. The boundaries of the mass with the trachea, brachiocephalic artery, and right brachiocephalic vein were unclear. Brush liquid-based cytology of the right middle lobe bronchus was performed, followed by histopathological biopsy. The pathological diagnosis was leiomyosarcoma in the middle lobe of the right lung. After the diagnosis, he underwent chemotherapy in another hospital, and the case was followed up for six months, during which no recurrence was noted. Conclusions Pulmonary and bronchial leiomyosarcomas often occur in young males with rapid progression and poor prognosis, but metastasis is rare. Surgical resection is the first-line treatment. We report a case of pulmonary bronchial leiomyosarcoma. The cytological, histological, immunohistochemical, and differential diagnoses were analysed to improve the understanding of the disease. Presently, there exist some challenges in diagnosing and treating pulmonary bronchial leiomyosarcoma. Early detection and treatment are important to improve prognosis. |
| format | Article |
| id | doaj-art-3732b54229434bfc8faa5b4f9c57d5c0 |
| institution | Kabale University |
| issn | 1471-2466 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj-art-3732b54229434bfc8faa5b4f9c57d5c02025-01-12T12:06:35ZengBMCBMC Pulmonary Medicine1471-24662025-01-012511610.1186/s12890-024-03472-1Primary bronchial leiomyosarcoma: a diagnostic challengeDan Chen0Shuai Luo1Department of Pathology, Beijing Jishuitan Hospital Guizhou HospitalDepartment of Pathology, Affiliated Hospital of Zunyi Medical UniversityAbstract Background Pulmonary bronchial leiomyosarcoma is an extremely rare malignant tumour of the lung originating from the mesenchymal tissue. The retroperitoneal region is the most common site of leiomyosarcoma. It exhibits a high degree of malignancy and a poor prognosis, thereby highlighting the significance of early diagnosis of this disease. Case demonstration A 61-year-old male with a smoking history of 40 + years was admitted to the hospital due to cough, expectoration, and shortness of breath that extended for half a year, which aggravated for two months and was succeeded by intermittent bloody sputum for one month. Chest computed tomography (CT) revealed a mass in the upper lobe of the right lung, which was identified as a malignant tumour lesion involving the upper thoracic oesophagus. The boundaries of the mass with the trachea, brachiocephalic artery, and right brachiocephalic vein were unclear. Brush liquid-based cytology of the right middle lobe bronchus was performed, followed by histopathological biopsy. The pathological diagnosis was leiomyosarcoma in the middle lobe of the right lung. After the diagnosis, he underwent chemotherapy in another hospital, and the case was followed up for six months, during which no recurrence was noted. Conclusions Pulmonary and bronchial leiomyosarcomas often occur in young males with rapid progression and poor prognosis, but metastasis is rare. Surgical resection is the first-line treatment. We report a case of pulmonary bronchial leiomyosarcoma. The cytological, histological, immunohistochemical, and differential diagnoses were analysed to improve the understanding of the disease. Presently, there exist some challenges in diagnosing and treating pulmonary bronchial leiomyosarcoma. Early detection and treatment are important to improve prognosis.https://doi.org/10.1186/s12890-024-03472-1BronchiLeiomyosarcomaCytologyHistologyDiagnosis |
| spellingShingle | Dan Chen Shuai Luo Primary bronchial leiomyosarcoma: a diagnostic challenge BMC Pulmonary Medicine Bronchi Leiomyosarcoma Cytology Histology Diagnosis |
| title | Primary bronchial leiomyosarcoma: a diagnostic challenge |
| title_full | Primary bronchial leiomyosarcoma: a diagnostic challenge |
| title_fullStr | Primary bronchial leiomyosarcoma: a diagnostic challenge |
| title_full_unstemmed | Primary bronchial leiomyosarcoma: a diagnostic challenge |
| title_short | Primary bronchial leiomyosarcoma: a diagnostic challenge |
| title_sort | primary bronchial leiomyosarcoma a diagnostic challenge |
| topic | Bronchi Leiomyosarcoma Cytology Histology Diagnosis |
| url | https://doi.org/10.1186/s12890-024-03472-1 |
| work_keys_str_mv | AT danchen primarybronchialleiomyosarcomaadiagnosticchallenge AT shuailuo primarybronchialleiomyosarcomaadiagnosticchallenge |