Efficacy and safety of hepatitis B vaccine: an umbrella review of meta-analyses
Background There is a lack of synthesis of literature to determine hepatitis B vaccine (HepB) strategies for hepatitis B virus (HBV) supported by quality evidence. We aimed to explore the efficacy and safety of HepB strategies among people with different characteristics.Research design and methods P...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
|
| Series: | Expert Review of Vaccines |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/14760584.2023.2289566 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846141400687575040 |
|---|---|
| author | Jiamin Qiu Shiwen Zhang Yonghui Feng Xin Su Jun Cai Shiyun Chen Jiazi Liu Shiqi Huang Haokun Huang Sui Zhu Huiyan Wen Jiaxin Li Haoyu Yan Zhiquan Diao Xiaofeng Liang Fangfang Zeng |
| author_facet | Jiamin Qiu Shiwen Zhang Yonghui Feng Xin Su Jun Cai Shiyun Chen Jiazi Liu Shiqi Huang Haokun Huang Sui Zhu Huiyan Wen Jiaxin Li Haoyu Yan Zhiquan Diao Xiaofeng Liang Fangfang Zeng |
| author_sort | Jiamin Qiu |
| collection | DOAJ |
| description | Background There is a lack of synthesis of literature to determine hepatitis B vaccine (HepB) strategies for hepatitis B virus (HBV) supported by quality evidence. We aimed to explore the efficacy and safety of HepB strategies among people with different characteristics.Research design and methods PubMed, Cochrane Library, Embase, and Web of Science were searched for meta-analyses comparing the efficacy and safety of HepB up to July 2023.Results Twenty-one meta-analyses comparing 83 associations were included, with 16 high quality, 4 moderate, and 1 low quality assessed by AMSTAR 2. Highly suggestive evidence supports HepB booster and HepB with 1018 adjuvant (HBsAg-1018) for improved seroprotection, and targeted and universal HepB vaccination reduced HBV infection Suggestive evidence indicated that targeted vaccination decreased the rate of hepatitis B surface antibody positivity and booster doses increased seroprotection in people aged 10–20. Weak evidence suggests potential local/systemic reaction risk with nucleotide analogs or HBsAg-1018. Convincing evidence shows HLA-DPB1*04:01 and DPB1*04:02 increased, while DPB1*05:01 decreased, hepatitis B antibody response. Obesity may reduce HepB seroprotection, as highly suggested.Conclusion Targeted vaccination could effectively reduce HBV infection, and adjuvant and booster vaccinations enhance seroprotection without significant reaction. Factors such as obesity and genetic polymorphisms may affect the efficacy. |
| format | Article |
| id | doaj-art-371e49de9d5243d2b74d4bf8d323001a |
| institution | Kabale University |
| issn | 1476-0584 1744-8395 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Expert Review of Vaccines |
| spelling | doaj-art-371e49de9d5243d2b74d4bf8d323001a2024-12-04T09:49:48ZengTaylor & Francis GroupExpert Review of Vaccines1476-05841744-83952024-12-01231698110.1080/14760584.2023.2289566Efficacy and safety of hepatitis B vaccine: an umbrella review of meta-analysesJiamin Qiu0Shiwen Zhang1Yonghui Feng2Xin Su3Jun Cai4Shiyun Chen5Jiazi Liu6Shiqi Huang7Haokun Huang8Sui Zhu9Huiyan Wen10Jiaxin Li11Haoyu Yan12Zhiquan Diao13Xiaofeng Liang14Fangfang Zeng15Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, PR ChinaDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, PR ChinaDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, PR ChinaDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, PR ChinaDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, PR ChinaDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, PR ChinaDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, PR ChinaDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, PR ChinaDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, PR ChinaDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, PR ChinaDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, PR ChinaDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, PR ChinaDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, PR ChinaDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, PR ChinaDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, PR ChinaDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, PR ChinaBackground There is a lack of synthesis of literature to determine hepatitis B vaccine (HepB) strategies for hepatitis B virus (HBV) supported by quality evidence. We aimed to explore the efficacy and safety of HepB strategies among people with different characteristics.Research design and methods PubMed, Cochrane Library, Embase, and Web of Science were searched for meta-analyses comparing the efficacy and safety of HepB up to July 2023.Results Twenty-one meta-analyses comparing 83 associations were included, with 16 high quality, 4 moderate, and 1 low quality assessed by AMSTAR 2. Highly suggestive evidence supports HepB booster and HepB with 1018 adjuvant (HBsAg-1018) for improved seroprotection, and targeted and universal HepB vaccination reduced HBV infection Suggestive evidence indicated that targeted vaccination decreased the rate of hepatitis B surface antibody positivity and booster doses increased seroprotection in people aged 10–20. Weak evidence suggests potential local/systemic reaction risk with nucleotide analogs or HBsAg-1018. Convincing evidence shows HLA-DPB1*04:01 and DPB1*04:02 increased, while DPB1*05:01 decreased, hepatitis B antibody response. Obesity may reduce HepB seroprotection, as highly suggested.Conclusion Targeted vaccination could effectively reduce HBV infection, and adjuvant and booster vaccinations enhance seroprotection without significant reaction. Factors such as obesity and genetic polymorphisms may affect the efficacy.https://www.tandfonline.com/doi/10.1080/14760584.2023.2289566Hepatitis B vaccinesefficiencysafetysystematic reviewmeta-analysis |
| spellingShingle | Jiamin Qiu Shiwen Zhang Yonghui Feng Xin Su Jun Cai Shiyun Chen Jiazi Liu Shiqi Huang Haokun Huang Sui Zhu Huiyan Wen Jiaxin Li Haoyu Yan Zhiquan Diao Xiaofeng Liang Fangfang Zeng Efficacy and safety of hepatitis B vaccine: an umbrella review of meta-analyses Expert Review of Vaccines Hepatitis B vaccines efficiency safety systematic review meta-analysis |
| title | Efficacy and safety of hepatitis B vaccine: an umbrella review of meta-analyses |
| title_full | Efficacy and safety of hepatitis B vaccine: an umbrella review of meta-analyses |
| title_fullStr | Efficacy and safety of hepatitis B vaccine: an umbrella review of meta-analyses |
| title_full_unstemmed | Efficacy and safety of hepatitis B vaccine: an umbrella review of meta-analyses |
| title_short | Efficacy and safety of hepatitis B vaccine: an umbrella review of meta-analyses |
| title_sort | efficacy and safety of hepatitis b vaccine an umbrella review of meta analyses |
| topic | Hepatitis B vaccines efficiency safety systematic review meta-analysis |
| url | https://www.tandfonline.com/doi/10.1080/14760584.2023.2289566 |
| work_keys_str_mv | AT jiaminqiu efficacyandsafetyofhepatitisbvaccineanumbrellareviewofmetaanalyses AT shiwenzhang efficacyandsafetyofhepatitisbvaccineanumbrellareviewofmetaanalyses AT yonghuifeng efficacyandsafetyofhepatitisbvaccineanumbrellareviewofmetaanalyses AT xinsu efficacyandsafetyofhepatitisbvaccineanumbrellareviewofmetaanalyses AT juncai efficacyandsafetyofhepatitisbvaccineanumbrellareviewofmetaanalyses AT shiyunchen efficacyandsafetyofhepatitisbvaccineanumbrellareviewofmetaanalyses AT jiaziliu efficacyandsafetyofhepatitisbvaccineanumbrellareviewofmetaanalyses AT shiqihuang efficacyandsafetyofhepatitisbvaccineanumbrellareviewofmetaanalyses AT haokunhuang efficacyandsafetyofhepatitisbvaccineanumbrellareviewofmetaanalyses AT suizhu efficacyandsafetyofhepatitisbvaccineanumbrellareviewofmetaanalyses AT huiyanwen efficacyandsafetyofhepatitisbvaccineanumbrellareviewofmetaanalyses AT jiaxinli efficacyandsafetyofhepatitisbvaccineanumbrellareviewofmetaanalyses AT haoyuyan efficacyandsafetyofhepatitisbvaccineanumbrellareviewofmetaanalyses AT zhiquandiao efficacyandsafetyofhepatitisbvaccineanumbrellareviewofmetaanalyses AT xiaofengliang efficacyandsafetyofhepatitisbvaccineanumbrellareviewofmetaanalyses AT fangfangzeng efficacyandsafetyofhepatitisbvaccineanumbrellareviewofmetaanalyses |