Biomarkers in Nasopharyngeal Carcinoma (NPC): Clinical relevance and prognostic potential
Nasopharyngeal carcinoma (NPC) is a unique malignancy with a distinct epidemiological pattern, primarily affecting populations in Southeast Asia and Southern China. The identification and utilization of biomarkers in NPC have significantly advanced over recent years, offering promising avenues for i...
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Elsevier
2024-09-01
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| Series: | Oral Oncology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772906024004862 |
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| author | Madhan Krishnan Shyamaladevi Babu |
| author_facet | Madhan Krishnan Shyamaladevi Babu |
| author_sort | Madhan Krishnan |
| collection | DOAJ |
| description | Nasopharyngeal carcinoma (NPC) is a unique malignancy with a distinct epidemiological pattern, primarily affecting populations in Southeast Asia and Southern China. The identification and utilization of biomarkers in NPC have significantly advanced over recent years, offering promising avenues for improving clinical outcomes. Epstein-Barr virus (EBV) DNA remains the most widely recognized biomarker, playing a pivotal role in early detection, prognostic evaluation, and monitoring treatment responses. However, ongoing research has identified additional biomarkers, such as circulating tumor cells (CTCs), microRNAs, and immune-related molecules that provide further prognostic insights. These biomarkers not only enhance our understanding of NPC pathogenesis but also support personalized treatment approaches by stratifying patients based on risk and expected treatment outcomes. Clinically, the application of these biomarkers has the potential to transform NPC management, enabling more precise interventions and improving survival rates while minimizing treatment-related toxicity. The integration of these biomarkers into routine clinical practice could facilitate early diagnosis, predict therapeutic responses, and identify patients at higher risk of recurrence. Despite these advancements, further validation in large-scale clinical trials is required to fully realize their potential. This review discusses the clinical relevance and prognostic potential of established and emerging biomarkers in NPC, emphasizing their role in refining patient management and enhancing personalized therapeutic strategies. The continued exploration of these biomarkers holds promise for the development of novel diagnostic tools and treatment paradigms, ultimately improving outcomes for patients with NPC. |
| format | Article |
| id | doaj-art-37079c1df40e4fe4bd34f1a04c71ccd4 |
| institution | Kabale University |
| issn | 2772-9060 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Oral Oncology Reports |
| spelling | doaj-art-37079c1df40e4fe4bd34f1a04c71ccd42025-01-09T06:17:01ZengElsevierOral Oncology Reports2772-90602024-09-0111100640Biomarkers in Nasopharyngeal Carcinoma (NPC): Clinical relevance and prognostic potentialMadhan Krishnan0Shyamaladevi Babu1Corresponding author. Faculty of Research, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, 603103, Tamilnadu, India.; Faculty of Research, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamilnadu, 603103, IndiaFaculty of Research, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamilnadu, 603103, IndiaNasopharyngeal carcinoma (NPC) is a unique malignancy with a distinct epidemiological pattern, primarily affecting populations in Southeast Asia and Southern China. The identification and utilization of biomarkers in NPC have significantly advanced over recent years, offering promising avenues for improving clinical outcomes. Epstein-Barr virus (EBV) DNA remains the most widely recognized biomarker, playing a pivotal role in early detection, prognostic evaluation, and monitoring treatment responses. However, ongoing research has identified additional biomarkers, such as circulating tumor cells (CTCs), microRNAs, and immune-related molecules that provide further prognostic insights. These biomarkers not only enhance our understanding of NPC pathogenesis but also support personalized treatment approaches by stratifying patients based on risk and expected treatment outcomes. Clinically, the application of these biomarkers has the potential to transform NPC management, enabling more precise interventions and improving survival rates while minimizing treatment-related toxicity. The integration of these biomarkers into routine clinical practice could facilitate early diagnosis, predict therapeutic responses, and identify patients at higher risk of recurrence. Despite these advancements, further validation in large-scale clinical trials is required to fully realize their potential. This review discusses the clinical relevance and prognostic potential of established and emerging biomarkers in NPC, emphasizing their role in refining patient management and enhancing personalized therapeutic strategies. The continued exploration of these biomarkers holds promise for the development of novel diagnostic tools and treatment paradigms, ultimately improving outcomes for patients with NPC.http://www.sciencedirect.com/science/article/pii/S2772906024004862Nasopharyngeal carcinoma (NPC)BiomarkersPrognostic indicatorsEpstein-barr virus (EBV) |
| spellingShingle | Madhan Krishnan Shyamaladevi Babu Biomarkers in Nasopharyngeal Carcinoma (NPC): Clinical relevance and prognostic potential Oral Oncology Reports Nasopharyngeal carcinoma (NPC) Biomarkers Prognostic indicators Epstein-barr virus (EBV) |
| title | Biomarkers in Nasopharyngeal Carcinoma (NPC): Clinical relevance and prognostic potential |
| title_full | Biomarkers in Nasopharyngeal Carcinoma (NPC): Clinical relevance and prognostic potential |
| title_fullStr | Biomarkers in Nasopharyngeal Carcinoma (NPC): Clinical relevance and prognostic potential |
| title_full_unstemmed | Biomarkers in Nasopharyngeal Carcinoma (NPC): Clinical relevance and prognostic potential |
| title_short | Biomarkers in Nasopharyngeal Carcinoma (NPC): Clinical relevance and prognostic potential |
| title_sort | biomarkers in nasopharyngeal carcinoma npc clinical relevance and prognostic potential |
| topic | Nasopharyngeal carcinoma (NPC) Biomarkers Prognostic indicators Epstein-barr virus (EBV) |
| url | http://www.sciencedirect.com/science/article/pii/S2772906024004862 |
| work_keys_str_mv | AT madhankrishnan biomarkersinnasopharyngealcarcinomanpcclinicalrelevanceandprognosticpotential AT shyamaladevibabu biomarkersinnasopharyngealcarcinomanpcclinicalrelevanceandprognosticpotential |