Zinc cooperates with p53 to inhibit the activity of mitochondrial aconitase through reactive oxygen species accumulation

Zinc cooperates with p53 to inhibit the activity of mitochondrial aconitase through reactive oxygen species accumulation

Abstract Metabolic reprogramming is a central hallmark of cancer. Therefore, targeting metabolism may provide an effective strategy for identifying promising drug targets for cancer treatment. In prostate cancer, cells undergo metabolic transformation from zinc‐accumulating, citrate‐producing cells...

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Main Authors: Ya‐Nan Xue, Ya‐Nan Liu, Jing Su, Jiu‐Ling Li, Yao Wu, Rui Guo, Bing‐Bing Yu, Xiao‐Yu Yan, Li‐Chao Zhang, Lian‐Kun Sun, Yang Li
Format: Article
Language:English
Published: Wiley 2019-05-01
Series:Cancer Medicine
Subjects:
mitochondrial aconitase
p53
ROS
zinc
Online Access:https://doi.org/10.1002/cam4.2130
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