Drug-Drug Interactions in the Red Zone of the Emergency Department: A Retrospective Study
Aim: This study aimed to assess the potential for drug-drug interactions in adult patients admitted to the emergency departments.Material and Methods: This cross-sectional study included 410 patients who were admitted to the red zone of the emergency departments, examined, treated, and received mult...
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| Format: | Article |
| Language: | English |
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Duzce University
2024-12-01
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| Series: | Düzce Tıp Fakültesi Dergisi |
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| Online Access: | https://dergipark.org.tr/en/download/article-file/4133593 |
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| author | Sema Erden Ertürk Mehmet Canacankatan Necmiye Canacankatan Canan Çulha Mesut Sancar Ş. Efsun Antmen |
| author_facet | Sema Erden Ertürk Mehmet Canacankatan Necmiye Canacankatan Canan Çulha Mesut Sancar Ş. Efsun Antmen |
| author_sort | Sema Erden Ertürk |
| collection | DOAJ |
| description | Aim: This study aimed to assess the potential for drug-drug interactions in adult patients admitted to the emergency departments.Material and Methods: This cross-sectional study included 410 patients who were admitted to the red zone of the emergency departments, examined, treated, and received multiple medications. Drug-drug interaction analysis was conducted using LexiInteract software.Results: The median age of patients was 63 (range, 19-96) years, with 55.4% (n=227) being female and 44.6% (n=183) were male. A total of 1,230 medications were identified among the patients. In 181 (44.1%) patients, 330 possible drug-drug interactions were detected. While there was no significant difference in the rate of drug-drug interactions between male and female patients (p=0.658), this rate was higher in patients aged 65 years and over (p=0.048) and patients with polypharmacy (p<0.001). Also, the interaction rates were higher in patients admitted with cerebrovascular disease (p=0.038) and trauma (p=0.002). According to the Lexicomp© drug information system, potential drug-drug interactions were classified into risk category C (n=299, 72.9%), risk category D (n=22, 5.4%), and risk category X (n=9, 2.2%). The most frequently interacting drug pairs were Furosemide-Salbutamol in category C, Enoxaparin-Acetylsalicylic acid in category D, and Dexketoprofen-Acetylsalicylic acid in category X.Conclusion: Nearly half of the patients treated in the red zone of the emergency department were at risk of drug interactions. Assessing the risk of drug-drug interactions is essential before initiating medical instructions in critical areas of emergency department patient care, and follow-up should be organized about potential adverse effects. |
| format | Article |
| id | doaj-art-36e1e2611d524b58807b2c275a813bcc |
| institution | Kabale University |
| issn | 1307-671X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Duzce University |
| record_format | Article |
| series | Düzce Tıp Fakültesi Dergisi |
| spelling | doaj-art-36e1e2611d524b58807b2c275a813bcc2024-12-25T18:30:00ZengDuzce UniversityDüzce Tıp Fakültesi Dergisi1307-671X2024-12-0126322823310.18678/dtfd.153068897Drug-Drug Interactions in the Red Zone of the Emergency Department: A Retrospective StudySema Erden Ertürk0https://orcid.org/0000-0002-1988-8674Mehmet Canacankatan1https://orcid.org/0000-0003-0772-9614Necmiye Canacankatan2https://orcid.org/0000-0003-3863-962XCanan Çulha3https://orcid.org/0000-0002-7714-7444Mesut Sancar4https://orcid.org/0000-0002-7445-3235Ş. Efsun Antmen5https://orcid.org/0000-0003-1270-2408MERSİN ÜNİVERSİTESİMERSİN ÜNİVERSİTESİMERSIN UNIVERSITY, FACULTY OF PHARMACYMERSIN UNIVERSITY, FACULTY OF PHARMACYMARMARA ÜNİVERSİTESİMERSİN ÜNİVERSİTESİAim: This study aimed to assess the potential for drug-drug interactions in adult patients admitted to the emergency departments.Material and Methods: This cross-sectional study included 410 patients who were admitted to the red zone of the emergency departments, examined, treated, and received multiple medications. Drug-drug interaction analysis was conducted using LexiInteract software.Results: The median age of patients was 63 (range, 19-96) years, with 55.4% (n=227) being female and 44.6% (n=183) were male. A total of 1,230 medications were identified among the patients. In 181 (44.1%) patients, 330 possible drug-drug interactions were detected. While there was no significant difference in the rate of drug-drug interactions between male and female patients (p=0.658), this rate was higher in patients aged 65 years and over (p=0.048) and patients with polypharmacy (p<0.001). Also, the interaction rates were higher in patients admitted with cerebrovascular disease (p=0.038) and trauma (p=0.002). According to the Lexicomp© drug information system, potential drug-drug interactions were classified into risk category C (n=299, 72.9%), risk category D (n=22, 5.4%), and risk category X (n=9, 2.2%). The most frequently interacting drug pairs were Furosemide-Salbutamol in category C, Enoxaparin-Acetylsalicylic acid in category D, and Dexketoprofen-Acetylsalicylic acid in category X.Conclusion: Nearly half of the patients treated in the red zone of the emergency department were at risk of drug interactions. Assessing the risk of drug-drug interactions is essential before initiating medical instructions in critical areas of emergency department patient care, and follow-up should be organized about potential adverse effects.https://dergipark.org.tr/en/download/article-file/4133593i̇laç etkileşimiacil serviskırmızı bölgeklinik eczacıdrug interactionemergency servicered zoneclinical pharmacist |
| spellingShingle | Sema Erden Ertürk Mehmet Canacankatan Necmiye Canacankatan Canan Çulha Mesut Sancar Ş. Efsun Antmen Drug-Drug Interactions in the Red Zone of the Emergency Department: A Retrospective Study Düzce Tıp Fakültesi Dergisi i̇laç etkileşimi acil servis kırmızı bölge klinik eczacı drug interaction emergency service red zone clinical pharmacist |
| title | Drug-Drug Interactions in the Red Zone of the Emergency Department: A Retrospective Study |
| title_full | Drug-Drug Interactions in the Red Zone of the Emergency Department: A Retrospective Study |
| title_fullStr | Drug-Drug Interactions in the Red Zone of the Emergency Department: A Retrospective Study |
| title_full_unstemmed | Drug-Drug Interactions in the Red Zone of the Emergency Department: A Retrospective Study |
| title_short | Drug-Drug Interactions in the Red Zone of the Emergency Department: A Retrospective Study |
| title_sort | drug drug interactions in the red zone of the emergency department a retrospective study |
| topic | i̇laç etkileşimi acil servis kırmızı bölge klinik eczacı drug interaction emergency service red zone clinical pharmacist |
| url | https://dergipark.org.tr/en/download/article-file/4133593 |
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