Brain Functional Reserve in the Context of Neuroplasticity after Stroke
Stroke is the second cause of death and more importantly first cause of disability in people over 40 years of age. Current therapeutic management of ischemic stroke does not provide fully satisfactory outcomes. Stroke management has significantly changed since the time when there were opened modern...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2019/9708905 |
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| author | Jan Dąbrowski Anna Czajka Justyna Zielińska-Turek Janusz Jaroszyński Marzena Furtak-Niczyporuk Aneta Mela Łukasz A. Poniatowski Bartłomiej Drop Małgorzata Dorobek Maria Barcikowska-Kotowicz Andrzej Ziemba |
| author_facet | Jan Dąbrowski Anna Czajka Justyna Zielińska-Turek Janusz Jaroszyński Marzena Furtak-Niczyporuk Aneta Mela Łukasz A. Poniatowski Bartłomiej Drop Małgorzata Dorobek Maria Barcikowska-Kotowicz Andrzej Ziemba |
| author_sort | Jan Dąbrowski |
| collection | DOAJ |
| description | Stroke is the second cause of death and more importantly first cause of disability in people over 40 years of age. Current therapeutic management of ischemic stroke does not provide fully satisfactory outcomes. Stroke management has significantly changed since the time when there were opened modern stroke units with early motor and speech rehabilitation in hospitals. In recent decades, researchers searched for biomarkers of ischemic stroke and neuroplasticity in order to determine effective diagnostics, prognostic assessment, and therapy. Complex background of events following ischemic episode hinders successful design of effective therapeutic strategies. So far, studies have proven that regeneration after stroke and recovery of lost functions may be assigned to neuronal plasticity understood as ability of brain to reorganize and rebuild as an effect of changed environmental conditions. As many neuronal processes influencing neuroplasticity depend on expression of particular genes and genetic diversity possibly influencing its effectiveness, knowledge on their mechanisms is necessary to understand this process. Epigenetic mechanisms occurring after stroke was briefly discussed in this paper including several mechanisms such as synaptic plasticity; neuro-, glio-, and angiogenesis processes; and growth of axon. |
| format | Article |
| id | doaj-art-36d1ef31c6fa46fb8e69434b6da6f0a8 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-36d1ef31c6fa46fb8e69434b6da6f0a82025-08-20T03:55:01ZengWileyNeural Plasticity2090-59041687-54432019-01-01201910.1155/2019/97089059708905Brain Functional Reserve in the Context of Neuroplasticity after StrokeJan Dąbrowski0Anna Czajka1Justyna Zielińska-Turek2Janusz Jaroszyński3Marzena Furtak-Niczyporuk4Aneta Mela5Łukasz A. Poniatowski6Bartłomiej Drop7Małgorzata Dorobek8Maria Barcikowska-Kotowicz9Andrzej Ziemba10Department of Applied Physiology, Mossakowski Medical Research Centre, Polish Academy of Sciences, Pawińskiego 5, 02-106 Warsaw, PolandDepartment Neurology, Central Clinical Hospital of the Ministry of the Interior and Administration, Wołoska 137, 02-507 Warsaw, PolandDepartment Neurology, Central Clinical Hospital of the Ministry of the Interior and Administration, Wołoska 137, 02-507 Warsaw, PolandDepartment of Public Health, 2nd Faculty of Medicine, Medical University of Lublin, Chodźki 1, 20-093 Lublin, PolandDepartment of Public Health, 2nd Faculty of Medicine, Medical University of Lublin, Chodźki 1, 20-093 Lublin, PolandDepartment of Experimental and Clinical Pharmacology, Centre for Preclinical Research and Technology (CePT), Medical University of Warsaw, Banacha 1B, 02-097 Warsaw, PolandDepartment of Experimental and Clinical Pharmacology, Centre for Preclinical Research and Technology (CePT), Medical University of Warsaw, Banacha 1B, 02-097 Warsaw, PolandDepartment of Information Technology and Medical Statistics, Faculty of Health Sciences, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, PolandDepartment Neurology, Central Clinical Hospital of the Ministry of the Interior and Administration, Wołoska 137, 02-507 Warsaw, PolandDepartment of Neurodegenerative Disorders, Mossakowski Medical Research Centre, Polish Academy of Sciences, Pawińskiego 5, 02-106 Warsaw, PolandDepartment of Applied Physiology, Mossakowski Medical Research Centre, Polish Academy of Sciences, Pawińskiego 5, 02-106 Warsaw, PolandStroke is the second cause of death and more importantly first cause of disability in people over 40 years of age. Current therapeutic management of ischemic stroke does not provide fully satisfactory outcomes. Stroke management has significantly changed since the time when there were opened modern stroke units with early motor and speech rehabilitation in hospitals. In recent decades, researchers searched for biomarkers of ischemic stroke and neuroplasticity in order to determine effective diagnostics, prognostic assessment, and therapy. Complex background of events following ischemic episode hinders successful design of effective therapeutic strategies. So far, studies have proven that regeneration after stroke and recovery of lost functions may be assigned to neuronal plasticity understood as ability of brain to reorganize and rebuild as an effect of changed environmental conditions. As many neuronal processes influencing neuroplasticity depend on expression of particular genes and genetic diversity possibly influencing its effectiveness, knowledge on their mechanisms is necessary to understand this process. Epigenetic mechanisms occurring after stroke was briefly discussed in this paper including several mechanisms such as synaptic plasticity; neuro-, glio-, and angiogenesis processes; and growth of axon.http://dx.doi.org/10.1155/2019/9708905 |
| spellingShingle | Jan Dąbrowski Anna Czajka Justyna Zielińska-Turek Janusz Jaroszyński Marzena Furtak-Niczyporuk Aneta Mela Łukasz A. Poniatowski Bartłomiej Drop Małgorzata Dorobek Maria Barcikowska-Kotowicz Andrzej Ziemba Brain Functional Reserve in the Context of Neuroplasticity after Stroke Neural Plasticity |
| title | Brain Functional Reserve in the Context of Neuroplasticity after Stroke |
| title_full | Brain Functional Reserve in the Context of Neuroplasticity after Stroke |
| title_fullStr | Brain Functional Reserve in the Context of Neuroplasticity after Stroke |
| title_full_unstemmed | Brain Functional Reserve in the Context of Neuroplasticity after Stroke |
| title_short | Brain Functional Reserve in the Context of Neuroplasticity after Stroke |
| title_sort | brain functional reserve in the context of neuroplasticity after stroke |
| url | http://dx.doi.org/10.1155/2019/9708905 |
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