In silico identification of the anticataract target of βB2-crystallin from Phaseolus vulgaris: a new insight into cataract treatment

In silico identification of the anticataract target of βB2-crystallin from Phaseolus vulgaris: a new insight into cataract treatment

IntroductionSevere protein clumping in the lens can block light and lead to vision issues in cataract patients. Recent studies have linked β-crystallins, which are key proteins in the lens, to the development of cataracts. Specifically, the S175G/H181Q mutation in the βB2-crystallin gene plays a maj...

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Main Authors: Sunday Amos Onikanni, Adewale Oluwaseun Fadaka, Tran Nhat Phong Dao, Valens Munyembaraga, Vincent Nyau, Nicole Remaliah Samantha Sibuyi, Morenike Grace Ajayi, Nguyen Thi Ai Nhung, Emmanuel Ejiofor, Basiru Olaitan Ajiboye, Minh Hoang Le, Hen-Hong Chang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Chemistry
Subjects:
βB2-crystallin
Phaseolus vulgaris
cataract
Schrödinger
conformation
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2024.1421534/full
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