Lineage-specific intersection of endothelin and GDNF signaling in enteric nervous system development

Lineage-specific intersection of endothelin and GDNF signaling in enteric nervous system development

Two major ligand-receptor signaling axes – endothelin Edn3 and its receptor Ednrb, and glial-derived neurotrophic factor (GDNF) and its receptor Ret – are required for migration of enteric nervous system (ENS) progenitors to the hindgut. Mutations in either component cause colonic aganglionosis, als...

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Bibliographic Details
Main Authors: Denise M Poltavski, Alexander T Cunha, Jaime Tan, Henry M Sucov, Takako Makita
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-12-01
Series:eLife
Subjects:
neural crest
placode
enteric nervous system
Hirschsprung disease
Online Access:https://elifesciences.org/articles/96424
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