Identification and analysis of pancreatic intraepithelial neoplasia: opportunities and challenges
Pancreatic intraepithelial neoplasia (PanIN) is the most common precursor lesion of pancreatic ductal adenocarcinoma (PDAC), which has poor prognosis with a short median overall survival of 6-12 months and a low 5-year survival rate of approximately 3%. It is crucial to remove PanIN lesions to preve...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1401829/full |
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| author | Ling-ling Pian Ling-ling Pian Mei-hui Song Teng-fei Wang Teng-fei Wang Ling Qi Tie-li Peng Ke-ping Xie |
| author_facet | Ling-ling Pian Ling-ling Pian Mei-hui Song Teng-fei Wang Teng-fei Wang Ling Qi Tie-li Peng Ke-ping Xie |
| author_sort | Ling-ling Pian |
| collection | DOAJ |
| description | Pancreatic intraepithelial neoplasia (PanIN) is the most common precursor lesion of pancreatic ductal adenocarcinoma (PDAC), which has poor prognosis with a short median overall survival of 6-12 months and a low 5-year survival rate of approximately 3%. It is crucial to remove PanIN lesions to prevent the development of invasive PDAC, as PDAC spreads rapidly outside the pancreas. This review aims to provide the latest knowledge on PanIN risk, pathology, cellular origin, genetic susceptibility, and diagnosis, while identifying research gaps that require further investigation in this understudied area of precancerous lesions. PanINs are classified into PanIN 1, PanIN 2, and PanIN 3, with PanIN 3 having the highest likelihood of developing into invasive PDAC. Differentiating between PanIN 2 and PanIN 3 is clinically significant. Genetic alterations found in PDAC are also present in PanIN and increase with the grade of PanIN. Imaging methods alone are insufficient for distinguishing PanIN, necessitating the use of genetic and molecular tests for identification. In addition, metabolomics technologies and miRNAs are playing an increasingly important role in the field of cancer diagnosis, offering more possibilities for efficient identification of PanIN. Although detecting and stratifying the risk of PanIN poses challenges, the combined utilization of imaging, genetics, and metabolomics holds promise for improving patient survival in this field. |
| format | Article |
| id | doaj-art-3693bcac1aa94dc4afa7f0fd45485b6e |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-3693bcac1aa94dc4afa7f0fd45485b6e2025-01-07T05:23:57ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-01-011510.3389/fendo.2024.14018291401829Identification and analysis of pancreatic intraepithelial neoplasia: opportunities and challengesLing-ling Pian0Ling-ling Pian1Mei-hui Song2Teng-fei Wang3Teng-fei Wang4Ling Qi5Tie-li Peng6Ke-ping Xie7School of Medicine, The South China University of Technology, Guangzhou, Guangdong, ChinaDivision of Gastroenterology, Institute of Digestive Disease, Affiliated Qingyuan Hospital, The Sixth Clinical Medical School, Guangzhou Medical University, Qingyuan People’s Hospital, Qingyuan, Guangdong, ChinaDivision of Gastroenterology, Institute of Digestive Disease, Affiliated Qingyuan Hospital, The Sixth Clinical Medical School, Guangzhou Medical University, Qingyuan People’s Hospital, Qingyuan, Guangdong, ChinaDivision of Gastroenterology, Institute of Digestive Disease, Affiliated Qingyuan Hospital, The Sixth Clinical Medical School, Guangzhou Medical University, Qingyuan People’s Hospital, Qingyuan, Guangdong, ChinaShandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong, ChinaDivision of Gastroenterology, Institute of Digestive Disease, Affiliated Qingyuan Hospital, The Sixth Clinical Medical School, Guangzhou Medical University, Qingyuan People’s Hospital, Qingyuan, Guangdong, ChinaDivision of Gastroenterology, Institute of Digestive Disease, Affiliated Qingyuan Hospital, The Sixth Clinical Medical School, Guangzhou Medical University, Qingyuan People’s Hospital, Qingyuan, Guangdong, ChinaSchool of Medicine, The South China University of Technology, Guangzhou, Guangdong, ChinaPancreatic intraepithelial neoplasia (PanIN) is the most common precursor lesion of pancreatic ductal adenocarcinoma (PDAC), which has poor prognosis with a short median overall survival of 6-12 months and a low 5-year survival rate of approximately 3%. It is crucial to remove PanIN lesions to prevent the development of invasive PDAC, as PDAC spreads rapidly outside the pancreas. This review aims to provide the latest knowledge on PanIN risk, pathology, cellular origin, genetic susceptibility, and diagnosis, while identifying research gaps that require further investigation in this understudied area of precancerous lesions. PanINs are classified into PanIN 1, PanIN 2, and PanIN 3, with PanIN 3 having the highest likelihood of developing into invasive PDAC. Differentiating between PanIN 2 and PanIN 3 is clinically significant. Genetic alterations found in PDAC are also present in PanIN and increase with the grade of PanIN. Imaging methods alone are insufficient for distinguishing PanIN, necessitating the use of genetic and molecular tests for identification. In addition, metabolomics technologies and miRNAs are playing an increasingly important role in the field of cancer diagnosis, offering more possibilities for efficient identification of PanIN. Although detecting and stratifying the risk of PanIN poses challenges, the combined utilization of imaging, genetics, and metabolomics holds promise for improving patient survival in this field.https://www.frontiersin.org/articles/10.3389/fendo.2024.1401829/fullPanINPDACKRAScellular origingenetic susceptibilitydiagnosis |
| spellingShingle | Ling-ling Pian Ling-ling Pian Mei-hui Song Teng-fei Wang Teng-fei Wang Ling Qi Tie-li Peng Ke-ping Xie Identification and analysis of pancreatic intraepithelial neoplasia: opportunities and challenges Frontiers in Endocrinology PanIN PDAC KRAS cellular origin genetic susceptibility diagnosis |
| title | Identification and analysis of pancreatic intraepithelial neoplasia: opportunities and challenges |
| title_full | Identification and analysis of pancreatic intraepithelial neoplasia: opportunities and challenges |
| title_fullStr | Identification and analysis of pancreatic intraepithelial neoplasia: opportunities and challenges |
| title_full_unstemmed | Identification and analysis of pancreatic intraepithelial neoplasia: opportunities and challenges |
| title_short | Identification and analysis of pancreatic intraepithelial neoplasia: opportunities and challenges |
| title_sort | identification and analysis of pancreatic intraepithelial neoplasia opportunities and challenges |
| topic | PanIN PDAC KRAS cellular origin genetic susceptibility diagnosis |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1401829/full |
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