Effects of lactic acid bacteria isolated from dairy products on lipid pattern of rats fed with a high fat diet
Background and Objectives: A unique characteristic of probiotics is obesity and fatty liver control. In this study, the effect of lactic-acid-bacteria (LABs) isolated from dairy products was investigated on weight changes, blood biochemical indexes and liver tissue in mice fed a high-fat diet. Mate...
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Tehran University of Medical Sciences
2025-06-01
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| Series: | Iranian Journal of Microbiology |
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| Online Access: | https://ijm.tums.ac.ir/index.php/ijm/article/view/5209 |
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| author | Sahar Fouladi Elham Moazamian |
| author_facet | Sahar Fouladi Elham Moazamian |
| author_sort | Sahar Fouladi |
| collection | DOAJ |
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Background and Objectives: A unique characteristic of probiotics is obesity and fatty liver control. In this study, the effect of lactic-acid-bacteria (LABs) isolated from dairy products was investigated on weight changes, blood biochemical indexes and liver tissue in mice fed a high-fat diet.
Materials and Methods: A total of 49 rats were assigned to 7 groups. The LAB-treated groups received the high-cholesterol diet supplemented with Lactobacillus reuteri, Lactobacillus plantarum, and Bifidobacterium animalis isolated from yogurt. At the end of 4 weeks, body weight changes, lipid factors and liver enzymes as well as liver lipid deposition and adipocyte size were measured.
Results: Serum low-density lipoprotein, total cholesterol, triglyceride levels and hepatic lipid deposition were significantly decreased in rats treated with LABs. The maximum and minimum weights were observed in the first and fourth weeks after treating with Lactobacillus and Bifidobacterium isolates, respectively. Liver enzymes were significantly decreased by LABs, especially in the group receiving concomitant administration of Lactobacillus and Bifidobacterium. Fatty liver process was reduced in the fat-fed group treated with L. reuteri.
Conclusion: LABs caused decreases in body weight gain, liver function, and adipocyte size. Therefore, coadministration of Lactobacillus and Bifidobacterium in dairy products can significantly decrease lipid profile.
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| format | Article |
| id | doaj-art-3693b42f00c048ed82b30f7e2f5a5c3d |
| institution | DOAJ |
| issn | 2008-3289 2008-4447 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Microbiology |
| spelling | doaj-art-3693b42f00c048ed82b30f7e2f5a5c3d2025-08-20T03:10:27ZengTehran University of Medical SciencesIranian Journal of Microbiology2008-32892008-44472025-06-0117310.18502/ijm.v17i3.18826Effects of lactic acid bacteria isolated from dairy products on lipid pattern of rats fed with a high fat dietSahar Fouladi0Elham Moazamian1Department of Microbiology, Faculty of Science, Agriculture and Modern Technology, Shiraz Branch, Islamic Azad University, Shiraz, IranDepartment of Microbiology, Faculty of Science, Agriculture and Modern Technology, Shiraz Branch, Islamic Azad University, Shiraz, Iran Background and Objectives: A unique characteristic of probiotics is obesity and fatty liver control. In this study, the effect of lactic-acid-bacteria (LABs) isolated from dairy products was investigated on weight changes, blood biochemical indexes and liver tissue in mice fed a high-fat diet. Materials and Methods: A total of 49 rats were assigned to 7 groups. The LAB-treated groups received the high-cholesterol diet supplemented with Lactobacillus reuteri, Lactobacillus plantarum, and Bifidobacterium animalis isolated from yogurt. At the end of 4 weeks, body weight changes, lipid factors and liver enzymes as well as liver lipid deposition and adipocyte size were measured. Results: Serum low-density lipoprotein, total cholesterol, triglyceride levels and hepatic lipid deposition were significantly decreased in rats treated with LABs. The maximum and minimum weights were observed in the first and fourth weeks after treating with Lactobacillus and Bifidobacterium isolates, respectively. Liver enzymes were significantly decreased by LABs, especially in the group receiving concomitant administration of Lactobacillus and Bifidobacterium. Fatty liver process was reduced in the fat-fed group treated with L. reuteri. Conclusion: LABs caused decreases in body weight gain, liver function, and adipocyte size. Therefore, coadministration of Lactobacillus and Bifidobacterium in dairy products can significantly decrease lipid profile. https://ijm.tums.ac.ir/index.php/ijm/article/view/5209ProbioticsObesityFatty liverLactobacillusBifidobacterium |
| spellingShingle | Sahar Fouladi Elham Moazamian Effects of lactic acid bacteria isolated from dairy products on lipid pattern of rats fed with a high fat diet Iranian Journal of Microbiology Probiotics Obesity Fatty liver Lactobacillus Bifidobacterium |
| title | Effects of lactic acid bacteria isolated from dairy products on lipid pattern of rats fed with a high fat diet |
| title_full | Effects of lactic acid bacteria isolated from dairy products on lipid pattern of rats fed with a high fat diet |
| title_fullStr | Effects of lactic acid bacteria isolated from dairy products on lipid pattern of rats fed with a high fat diet |
| title_full_unstemmed | Effects of lactic acid bacteria isolated from dairy products on lipid pattern of rats fed with a high fat diet |
| title_short | Effects of lactic acid bacteria isolated from dairy products on lipid pattern of rats fed with a high fat diet |
| title_sort | effects of lactic acid bacteria isolated from dairy products on lipid pattern of rats fed with a high fat diet |
| topic | Probiotics Obesity Fatty liver Lactobacillus Bifidobacterium |
| url | https://ijm.tums.ac.ir/index.php/ijm/article/view/5209 |
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