Pharmacological correction of ulcerative colitis with dalargin
Introduction: Ulcerative colitis is a chronic colonic disease with frequent relapses, affecting mainly people of active age. The effectiveness of existing treatment methods remains low. Dalargin has the following pharmacological effects: antioxidant, membrane-stabilizing and immunomodulatory, which...
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Belgorod National Research University
2024-12-01
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| Series: | Research Results in Pharmacology |
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| Online Access: | https://rrpharmacology.ru/index.php/journal/article/view/513 |
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| author | Andrei Yu. Liashev Galina S. Mal’ |
| author_facet | Andrei Yu. Liashev Galina S. Mal’ |
| author_sort | Andrei Yu. Liashev |
| collection | DOAJ |
| description | Introduction: Ulcerative colitis is a chronic colonic disease with frequent relapses, affecting mainly people of active age. The effectiveness of existing treatment methods remains low. Dalargin has the following pharmacological effects: antioxidant, membrane-stabilizing and immunomodulatory, which are important in treating ulcerative colitis. The aim of the studywas to increase the effectiveness of pharmacological correction of ulcerative colitis with dalargin.
Materials and Methods: Ulcerative colitis was simulated by replacing drinking water with a 5% solution of dextran sodium sulfate for 5 days. The mice were killed on the 5th, 7th and 28thdays; the colon was removed. Dalargin was dissolved in a 0.9% sodium chloride solution, injected subcutaneously daily at a dose of 100 μg/kg once a day for 7 days. Sulfasalazine was used as a reference drug.
Results and Discussion: The dalargin administration decreased disease activity index, pathological colonic shortening, prevalence of ulcers and infiltrates in colon, increased goblet cell number, acid and neutral mucins concentrations in mice with ulcerative colitis. The mechanisms of pharmacological dalargin effect include: drop in proinflammatory interleukins (IL-1β, IL-6, IL-17) and matrix metalloproteinases concentration, TGF-β, arising in anti-inflammatory interleukins, epidermal growth factor, inhibitor of matrix metalloproteinases-2 content. Dalargincorrected phagocytes activity and leukocyte indices. Dalargin action in ulcerative colitis is higher than that of sulfasalazine.
Conclusion: Pharmacological dalargin effect on ulcerative colitis development was explained by its effect on opioid μ-receptors on macrophages, neutrophils, and lymphocytes of the colonic wall. The therapeutic action involves antioxidant effect and endothelial dysfunction correction. |
| format | Article |
| id | doaj-art-367625abc6d64627a5ee0e59741cf544 |
| institution | Kabale University |
| issn | 2658-381X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Belgorod National Research University |
| record_format | Article |
| series | Research Results in Pharmacology |
| spelling | doaj-art-367625abc6d64627a5ee0e59741cf5442025-01-08T13:00:31ZengBelgorod National Research UniversityResearch Results in Pharmacology2658-381X2024-12-01104435910.18413/rrpharmacology.10.513Pharmacological correction of ulcerative colitis with dalarginAndrei Yu. Liashev0https://orcid.org/0000-0001-7170-0416Galina S. Mal’1https://orcid.org/0000-0003-2723-781XKursk State Medical UniversityKursk State Medical UniversityIntroduction: Ulcerative colitis is a chronic colonic disease with frequent relapses, affecting mainly people of active age. The effectiveness of existing treatment methods remains low. Dalargin has the following pharmacological effects: antioxidant, membrane-stabilizing and immunomodulatory, which are important in treating ulcerative colitis. The aim of the studywas to increase the effectiveness of pharmacological correction of ulcerative colitis with dalargin. Materials and Methods: Ulcerative colitis was simulated by replacing drinking water with a 5% solution of dextran sodium sulfate for 5 days. The mice were killed on the 5th, 7th and 28thdays; the colon was removed. Dalargin was dissolved in a 0.9% sodium chloride solution, injected subcutaneously daily at a dose of 100 μg/kg once a day for 7 days. Sulfasalazine was used as a reference drug. Results and Discussion: The dalargin administration decreased disease activity index, pathological colonic shortening, prevalence of ulcers and infiltrates in colon, increased goblet cell number, acid and neutral mucins concentrations in mice with ulcerative colitis. The mechanisms of pharmacological dalargin effect include: drop in proinflammatory interleukins (IL-1β, IL-6, IL-17) and matrix metalloproteinases concentration, TGF-β, arising in anti-inflammatory interleukins, epidermal growth factor, inhibitor of matrix metalloproteinases-2 content. Dalargincorrected phagocytes activity and leukocyte indices. Dalargin action in ulcerative colitis is higher than that of sulfasalazine. Conclusion: Pharmacological dalargin effect on ulcerative colitis development was explained by its effect on opioid μ-receptors on macrophages, neutrophils, and lymphocytes of the colonic wall. The therapeutic action involves antioxidant effect and endothelial dysfunction correction.https://rrpharmacology.ru/index.php/journal/article/view/513dalargingoblet cellsinterleukinsmatrix metalloproteinasesmucinsulcerative colitis |
| spellingShingle | Andrei Yu. Liashev Galina S. Mal’ Pharmacological correction of ulcerative colitis with dalargin Research Results in Pharmacology dalargin goblet cells interleukins matrix metalloproteinases mucins ulcerative colitis |
| title | Pharmacological correction of ulcerative colitis with dalargin |
| title_full | Pharmacological correction of ulcerative colitis with dalargin |
| title_fullStr | Pharmacological correction of ulcerative colitis with dalargin |
| title_full_unstemmed | Pharmacological correction of ulcerative colitis with dalargin |
| title_short | Pharmacological correction of ulcerative colitis with dalargin |
| title_sort | pharmacological correction of ulcerative colitis with dalargin |
| topic | dalargin goblet cells interleukins matrix metalloproteinases mucins ulcerative colitis |
| url | https://rrpharmacology.ru/index.php/journal/article/view/513 |
| work_keys_str_mv | AT andreiyuliashev pharmacologicalcorrectionofulcerativecolitiswithdalargin AT galinasmal pharmacologicalcorrectionofulcerativecolitiswithdalargin |