Real-world evidence of chemotherapy effects in advanced pancreatic ductal adenocarcinoma: prognostic significance of TP53 status in gemcitabine plus nab-paclitaxel therapy

Real-world evidence of chemotherapy effects in advanced pancreatic ductal adenocarcinoma: prognostic significance of TP53 status in gemcitabine plus nab-paclitaxel therapy

Background: Gemcitabine plus nab-paclitaxel (GnP) and FOLFIRINOX (FFX) therapies are widely used to treat advanced pancreatic ductal adenocarcinoma (PDAC). This study aimed to identify the prognostic factors associated with these regimens, focusing on key genomic alterations in the ‘Big Four’ genes...

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Bibliographic Details
Main Authors: M. Sugimori, A. Hirotani, H. Yamazaki, M. Oshi, K. Kawashima, H. Tsuchiya, Y. Kanemaru, Y. Suzuki, S. Onodera, H. Miwa, A. Nozaki, K. Sugimori, C. Kunisaki, M. Kudo, M. Morimoto, S. Maeda
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:ESMO Gastrointestinal Oncology
Subjects:
genomic profiles
pancreatic ductal adenocarcinoma
time to progression
tumour protein p53 mutations
gemcitabine plus nab-paclitaxel therapy
leucovorin, fluorouracil, irinotecan, and oxaliplatin therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2949819825000901
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