Influence of subclinical hypothyroidism and brain-derived neurotropic factor on telomere length dynamics in type 1 diabetic pregnancies and their newborns
Abstract Thyroid dysfunctions are common in type 1 diabetes mellitus (T1DM) pregnancies, impacting embryogenesis and fetal neurodevelopment. This study investigates the effects of subclinical hypothyroidism and BDNF (Brain-derived neurotrophic factor) telomere length in T1DM mothers and their newbor...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-024-84430-z |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841559591004930048 |
|---|---|
| author | Josip Djelmis Marina Ivanisevic |
| author_facet | Josip Djelmis Marina Ivanisevic |
| author_sort | Josip Djelmis |
| collection | DOAJ |
| description | Abstract Thyroid dysfunctions are common in type 1 diabetes mellitus (T1DM) pregnancies, impacting embryogenesis and fetal neurodevelopment. This study investigates the effects of subclinical hypothyroidism and BDNF (Brain-derived neurotrophic factor) telomere length in T1DM mothers and their newborns. In a recent study, researchers found an inverse relationship between TSH (thyroid-stimulating hormone) levels and telomere length in the cord blood of newborns. This was prospective cohort analysis of 70 mothers and their newborns with T1DM. The study measured leukocyte telomere length (LTL) in maternal and neonatal samples. Subclinical hypothyroidism during the first trimester was characterized by TSH levels ranging from 2.5 to 5.0 mIU/L alongside normal free thyroxine (FT4) concentrations. In this study, we proved that maternal telomere length predicts telomere length in the newborn. Furthermore, we investigated the influence of maternal hypothyroidism on telomere length in the newborn. Maternal hypothyroidism in the first trimester of pregnancy has a strong influence on the shortening of newborn telomeres. BDNF has a positive effect on maternal and newborn telomere length. These results can have an important impact on the subsequent development of a child born to a diabetic mother. Health and disease associated with telomere length later in life may be programmed at birth. |
| format | Article |
| id | doaj-art-35d1552457ec4790b2807a5e32dab23b |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-35d1552457ec4790b2807a5e32dab23b2025-01-05T12:20:50ZengNature PortfolioScientific Reports2045-23222025-01-011511810.1038/s41598-024-84430-zInfluence of subclinical hypothyroidism and brain-derived neurotropic factor on telomere length dynamics in type 1 diabetic pregnancies and their newbornsJosip Djelmis0Marina Ivanisevic1School of Medicine, University of ZagrebDepartment of Obstetrics and Gynecology, University Hospital Centre ZagrebAbstract Thyroid dysfunctions are common in type 1 diabetes mellitus (T1DM) pregnancies, impacting embryogenesis and fetal neurodevelopment. This study investigates the effects of subclinical hypothyroidism and BDNF (Brain-derived neurotrophic factor) telomere length in T1DM mothers and their newborns. In a recent study, researchers found an inverse relationship between TSH (thyroid-stimulating hormone) levels and telomere length in the cord blood of newborns. This was prospective cohort analysis of 70 mothers and their newborns with T1DM. The study measured leukocyte telomere length (LTL) in maternal and neonatal samples. Subclinical hypothyroidism during the first trimester was characterized by TSH levels ranging from 2.5 to 5.0 mIU/L alongside normal free thyroxine (FT4) concentrations. In this study, we proved that maternal telomere length predicts telomere length in the newborn. Furthermore, we investigated the influence of maternal hypothyroidism on telomere length in the newborn. Maternal hypothyroidism in the first trimester of pregnancy has a strong influence on the shortening of newborn telomeres. BDNF has a positive effect on maternal and newborn telomere length. These results can have an important impact on the subsequent development of a child born to a diabetic mother. Health and disease associated with telomere length later in life may be programmed at birth.https://doi.org/10.1038/s41598-024-84430-zBrain-derived neurotrophic factorNewbornPregnancySubclinical hypothyroidismType 1 diabetes mellitus |
| spellingShingle | Josip Djelmis Marina Ivanisevic Influence of subclinical hypothyroidism and brain-derived neurotropic factor on telomere length dynamics in type 1 diabetic pregnancies and their newborns Scientific Reports Brain-derived neurotrophic factor Newborn Pregnancy Subclinical hypothyroidism Type 1 diabetes mellitus |
| title | Influence of subclinical hypothyroidism and brain-derived neurotropic factor on telomere length dynamics in type 1 diabetic pregnancies and their newborns |
| title_full | Influence of subclinical hypothyroidism and brain-derived neurotropic factor on telomere length dynamics in type 1 diabetic pregnancies and their newborns |
| title_fullStr | Influence of subclinical hypothyroidism and brain-derived neurotropic factor on telomere length dynamics in type 1 diabetic pregnancies and their newborns |
| title_full_unstemmed | Influence of subclinical hypothyroidism and brain-derived neurotropic factor on telomere length dynamics in type 1 diabetic pregnancies and their newborns |
| title_short | Influence of subclinical hypothyroidism and brain-derived neurotropic factor on telomere length dynamics in type 1 diabetic pregnancies and their newborns |
| title_sort | influence of subclinical hypothyroidism and brain derived neurotropic factor on telomere length dynamics in type 1 diabetic pregnancies and their newborns |
| topic | Brain-derived neurotrophic factor Newborn Pregnancy Subclinical hypothyroidism Type 1 diabetes mellitus |
| url | https://doi.org/10.1038/s41598-024-84430-z |
| work_keys_str_mv | AT josipdjelmis influenceofsubclinicalhypothyroidismandbrainderivedneurotropicfactorontelomerelengthdynamicsintype1diabeticpregnanciesandtheirnewborns AT marinaivanisevic influenceofsubclinicalhypothyroidismandbrainderivedneurotropicfactorontelomerelengthdynamicsintype1diabeticpregnanciesandtheirnewborns |