Genetic Characteristics and Research Progress of Feline Coronavirus
Feline coronavirus (FCoV) is classified into two biotypes: feline infectious peritonitis virus (FIPV) and feline enteric coronavirus (FECV). FIPV and FECV might evolve and mutate via genetic recombination and mutation, leading to novel subtypes and variants. This study examined the genomic structure...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Laboratory Animal and Comparative Medicine
2024-12-01
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| Series: | Shiyan dongwu yu bijiao yixue |
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| Online Access: | https://www.slarc.org.cn/dwyx/CN/10.12300/j.issn.1674-5817.2024.069 |
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| author | TAO Lingyun |
| author_facet | TAO Lingyun |
| author_sort | TAO Lingyun |
| collection | DOAJ |
| description | Feline coronavirus (FCoV) is classified into two biotypes: feline infectious peritonitis virus (FIPV) and feline enteric coronavirus (FECV). FIPV and FECV might evolve and mutate via genetic recombination and mutation, leading to novel subtypes and variants. This study examined the genomic structure and biological subtyping of FCoV, analyzed the infection characteristics of FIPV and FECV, and investigated the mechanisms of FECV transforming into FIPV. The findings revealed that while their genome structures were fundamentally similar, differences in their ability to efficiently infect monocytes/macrophages significantly influenced their pathogenicity and transmission characteristics, with FIPV exhibiting higher virulence. Moreover, the analysis of the open reading frames (ORF)3/7 as well as the N/S sequences of FIPV indicated that its non-structural proteins were associated with modulation of the host immune system. These proteins enabled immune evasion, leading to more severe disease. The genomic variability of FCoV constitutes an important foundation for studying the pathogenicity and epidemiology of FIPV and FECV, and offers references for virus detection and drug development. |
| format | Article |
| id | doaj-art-35cc4f845f0c4d24a1a6b308fb4b2bbd |
| institution | Kabale University |
| issn | 1674-5817 |
| language | zho |
| publishDate | 2024-12-01 |
| publisher | Editorial Office of Laboratory Animal and Comparative Medicine |
| record_format | Article |
| series | Shiyan dongwu yu bijiao yixue |
| spelling | doaj-art-35cc4f845f0c4d24a1a6b308fb4b2bbd2025-01-06T05:12:09ZzhoEditorial Office of Laboratory Animal and Comparative MedicineShiyan dongwu yu bijiao yixue1674-58172024-12-0144666166610.12300/j.issn.1674-5817.2024.0691674-5817（2024）06-0661-06Genetic Characteristics and Research Progress of Feline CoronavirusTAO Lingyun0Shanghai Laboratory Animal Research Center, Shanghai201203, ChinaFeline coronavirus (FCoV) is classified into two biotypes: feline infectious peritonitis virus (FIPV) and feline enteric coronavirus (FECV). FIPV and FECV might evolve and mutate via genetic recombination and mutation, leading to novel subtypes and variants. This study examined the genomic structure and biological subtyping of FCoV, analyzed the infection characteristics of FIPV and FECV, and investigated the mechanisms of FECV transforming into FIPV. The findings revealed that while their genome structures were fundamentally similar, differences in their ability to efficiently infect monocytes/macrophages significantly influenced their pathogenicity and transmission characteristics, with FIPV exhibiting higher virulence. Moreover, the analysis of the open reading frames (ORF)3/7 as well as the N/S sequences of FIPV indicated that its non-structural proteins were associated with modulation of the host immune system. These proteins enabled immune evasion, leading to more severe disease. The genomic variability of FCoV constitutes an important foundation for studying the pathogenicity and epidemiology of FIPV and FECV, and offers references for virus detection and drug development.https://www.slarc.org.cn/dwyx/CN/10.12300/j.issn.1674-5817.2024.069feline coronavirusfeline infectious peritonitis virusfeline enteric coronavirusfeline infectious peritonitisgenome |
| spellingShingle | TAO Lingyun Genetic Characteristics and Research Progress of Feline Coronavirus Shiyan dongwu yu bijiao yixue feline coronavirus feline infectious peritonitis virus feline enteric coronavirus feline infectious peritonitis genome |
| title | Genetic Characteristics and Research Progress of Feline Coronavirus |
| title_full | Genetic Characteristics and Research Progress of Feline Coronavirus |
| title_fullStr | Genetic Characteristics and Research Progress of Feline Coronavirus |
| title_full_unstemmed | Genetic Characteristics and Research Progress of Feline Coronavirus |
| title_short | Genetic Characteristics and Research Progress of Feline Coronavirus |
| title_sort | genetic characteristics and research progress of feline coronavirus |
| topic | feline coronavirus feline infectious peritonitis virus feline enteric coronavirus feline infectious peritonitis genome |
| url | https://www.slarc.org.cn/dwyx/CN/10.12300/j.issn.1674-5817.2024.069 |
| work_keys_str_mv | AT taolingyun geneticcharacteristicsandresearchprogressoffelinecoronavirus |