Twin neurological enigmas radiological and medical insight into a dual encounter with metformin induced encephalopathy
Metformin induced encephalopathy is an infrequent but critical neurological complication associated with metformin therapy. Lentiform fork sign, an infrequent radiological imaging (MRI), presents a distinctive image in basal ganglia pathology. It manifests as a V-shaped or fork-like hyperintensity i...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Society of Diabetic Nephropathy Prevention
2024-06-01
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| Series: | Journal of Nephropharmacology |
| Subjects: | |
| Online Access: | https://jnephropharmacology.com/PDF/npj-13-e11681.pdf |
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| Summary: | Metformin induced encephalopathy is an infrequent but critical neurological complication associated with metformin therapy. Lentiform fork sign, an infrequent radiological imaging (MRI), presents a distinctive image in basal ganglia pathology. It manifests as a V-shaped or fork-like hyperintensity in the globus pallidus and putamen regions. While it has been associated with various conditions like diabetic uremic encephalopathy, toxins like methanol and ethylene glycol, Neurodegenerative etiologies. Its occurrence following metformin administration remains rare because of contraindication of prescribing metformin in a hemodialysis patient due to its well-known side of lactic acidosis. This abstract aims to report and discuss two cases presenting the lentiform forks sign following metformin administration in patients undergoing hemodialysis due to end-stage renal disease. Symptomatic involvement of basal ganglia as metformin induced encephalopathy and resolution with clinical recovery following hemodialysis are rarely reported. We hereby report two such cases which shows symptomatic improvement clinically as well as radiologically following hemodialysis |
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| ISSN: | 2345-4202 |