Biophysical and spectroscopical insights into structural modulation of species in the aggregation pathway of superoxide dismutase 1

Biophysical and spectroscopical insights into structural modulation of species in the aggregation pathway of superoxide dismutase 1

Abstract Superoxide dismutase 1 (SOD1) aggregation is implicated in the development of Amyotrophic Lateral Sclerosis (ALS). Despite knowledge of the role of SOD1 aggregation, the mechanistic understanding remains elusive. Our investigation aimed to unravel the complex steps involved in SOD1 aggregat...

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Bibliographic Details
Main Authors: Vijay Raj Tomar, Shilpa Sharma, Soumik Siddhanta, Shashank Deep
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-025-01421-5
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