Rapid and scalable detection of synthetic mRNA byproducts using polynucleotide phosphorylase and polythymidine oligonucleotides

Rapid and scalable detection of synthetic mRNA byproducts using polynucleotide phosphorylase and polythymidine oligonucleotides

Production and storage of synthetic mRNA can introduce a variety of byproducts which reduce the overall integrity and functionality of mRNA vaccines and therapeutics. mRNA integrity is therefore designated as a critical quality attribute which must be evaluated with state-of-the-art analytical metho...

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Bibliographic Details
Main Authors: Francis Combes, Thanh-Huong Bui, Frida J. Pettersson, Sjoerd Hak
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:RNA Biology
Subjects:
mRNA
byproducts
PNPase
assay
high-throughput
Online Access:https://www.tandfonline.com/doi/10.1080/15476286.2024.2363029
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