Nox1/PAK1 is required for angiotensin II-induced vascular inflammation and abdominal aortic aneurysm formation

Nox1/PAK1 is required for angiotensin II-induced vascular inflammation and abdominal aortic aneurysm formation

NADPH oxidase 1 (Nox1) is a major isoform of Nox in vascular smooth muscle cells (VSMCs). VSMC activation and extracellular matrix (ECM) remodelling induce abdominal aortic aneurysm (AAA). In this study, we aim to determine the role of Nox1 in the progression of AAA and explore the underling mechani...

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Bibliographic Details
Main Authors: Hui He, Tianyu Jiang, Meng Ding, Yuan Zhu, Xiaoting Xu, Yashuang Huang, Wenfeng Yu, Hailong Ou
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Redox Biology
Subjects:
NADPH oxidase 1
Abdominal aortic aneurysm
PAK1
Smooth muscle cell
Vascular inflammation
MMP2
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724004555
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