Alternatively spliced mini-exon B in PTPδ regulates excitatory synapses through cell-type-specific trans-synaptic PTPδ-IL1RAP interaction

Alternatively spliced mini-exon B in PTPδ regulates excitatory synapses through cell-type-specific trans-synaptic PTPδ-IL1RAP interaction

Abstract PTPδ, encoded by PTPRD, is implicated in various neurological, psychiatric, and neurodevelopmental disorders, but the underlying mechanisms remain unclear. PTPδ trans-synaptically interacts with multiple postsynaptic adhesion molecules, which involves its extracellular alternatively spliced...

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Main Authors: Seoyeong Kim, Jae Jin Shin, Muwon Kang, Yeji Yang, Yi Sul Cho, Hyojung Paik, Jimin Kim, Yunho Yi, Suho Lee, Hei Yeun Koo, Jinwoong Bok, Yong Chul Bae, Jin Young Kim, Eunjoon Kim
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59685-3
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https://doi.org/10.1038/s41467-025-59685-3

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