Psychiatric Assessment in Patients with Mild Temporal Lobe Epilepsy
Objectives. The findings of previous studies focused on personality disorders in epileptic patients are difficult to interpret due to nonhomogeneous samples and noncomparable methods. Here, we aimed at studying the personality profile in patients with mild temporal lobe epilepsy (mTLE) with psychiat...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2019/4139404 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841524773145804800 |
|---|---|
| author | Antonella Bruni Iolanda Martino Maria Eugenia Caligiuri Maria Grazia Vaccaro Michele Trimboli Cristina Segura Garcia Pasquale De Fazio Antonio Gambardella Angelo Labate |
| author_facet | Antonella Bruni Iolanda Martino Maria Eugenia Caligiuri Maria Grazia Vaccaro Michele Trimboli Cristina Segura Garcia Pasquale De Fazio Antonio Gambardella Angelo Labate |
| author_sort | Antonella Bruni |
| collection | DOAJ |
| description | Objectives. The findings of previous studies focused on personality disorders in epileptic patients are difficult to interpret due to nonhomogeneous samples and noncomparable methods. Here, we aimed at studying the personality profile in patients with mild temporal lobe epilepsy (mTLE) with psychiatric comorbidity. Materials and Methods. Thirty-five patients with mTLE (22 males, mean age 40.7±12.1) underwent awake and sleep EEG, 3T brain MRI, and an extensive standardized diagnostic neuropsychiatric battery: Temperament and Character Inventory-Revised (TCI-R), Beck Depression Inventory-2, and State-Trait Anxiety Inventory. Drug history was collected in detail. Hierarchical Cluster Analysis was performed on TCI-R data, while all other clinical and psychological variables were compared across the resulting clusters. Results. Scores of Harm Avoidance (HA), Reward Dependence (RD), Persistence (P), Cooperativeness (C), and Self-Transcendence (ST) allowed the identification of two clusters, describing different personality subtypes. Cluster 1 was characterized by an early onset, more severe anxiety traits, and combined drug therapy (antiepileptic drug and Benzodiazepine/Selective Serotonin Reuptake Inhibitors) compared to Cluster 2. Conclusions. Our findings suggest that different personality traits may play a role in determining the clinical outcome in patients with mTLE. Specifically, lower scores of HA, RD, P, C, and ST were associated with worse clinical outcome. Thus, personality assessment could serve as an early indicator of greater disease severity, improving the management of mTLE. |
| format | Article |
| id | doaj-art-3568159908664a54b5df4e133e3a5199 |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-3568159908664a54b5df4e133e3a51992025-02-03T05:47:24ZengWileyBehavioural Neurology0953-41801875-85842019-01-01201910.1155/2019/41394044139404Psychiatric Assessment in Patients with Mild Temporal Lobe EpilepsyAntonella Bruni0Iolanda Martino1Maria Eugenia Caligiuri2Maria Grazia Vaccaro3Michele Trimboli4Cristina Segura Garcia5Pasquale De Fazio6Antonio Gambardella7Angelo Labate8Neurology Unit, Department of Medical and Surgical Sciences, University Magna Graecia, Catanzaro, ItalyNeurology Unit, Department of Medical and Surgical Sciences, University Magna Graecia, Catanzaro, ItalyNeuroscience Research Center, University Magna Graecia, Catanzaro, ItalyNeurology Unit, Department of Medical and Surgical Sciences, University Magna Graecia, Catanzaro, ItalyNeurology Unit, Department of Medical and Surgical Sciences, University Magna Graecia, Catanzaro, ItalyPsychiatric Unit, Department of Health Sciences, University Magna Graecia, Catanzaro, ItalyPsychiatric Unit, Department of Health Sciences, University Magna Graecia, Catanzaro, ItalyNeurology Unit, Department of Medical and Surgical Sciences, University Magna Graecia, Catanzaro, ItalyNeurology Unit, Department of Medical and Surgical Sciences, University Magna Graecia, Catanzaro, ItalyObjectives. The findings of previous studies focused on personality disorders in epileptic patients are difficult to interpret due to nonhomogeneous samples and noncomparable methods. Here, we aimed at studying the personality profile in patients with mild temporal lobe epilepsy (mTLE) with psychiatric comorbidity. Materials and Methods. Thirty-five patients with mTLE (22 males, mean age 40.7±12.1) underwent awake and sleep EEG, 3T brain MRI, and an extensive standardized diagnostic neuropsychiatric battery: Temperament and Character Inventory-Revised (TCI-R), Beck Depression Inventory-2, and State-Trait Anxiety Inventory. Drug history was collected in detail. Hierarchical Cluster Analysis was performed on TCI-R data, while all other clinical and psychological variables were compared across the resulting clusters. Results. Scores of Harm Avoidance (HA), Reward Dependence (RD), Persistence (P), Cooperativeness (C), and Self-Transcendence (ST) allowed the identification of two clusters, describing different personality subtypes. Cluster 1 was characterized by an early onset, more severe anxiety traits, and combined drug therapy (antiepileptic drug and Benzodiazepine/Selective Serotonin Reuptake Inhibitors) compared to Cluster 2. Conclusions. Our findings suggest that different personality traits may play a role in determining the clinical outcome in patients with mTLE. Specifically, lower scores of HA, RD, P, C, and ST were associated with worse clinical outcome. Thus, personality assessment could serve as an early indicator of greater disease severity, improving the management of mTLE.http://dx.doi.org/10.1155/2019/4139404 |
| spellingShingle | Antonella Bruni Iolanda Martino Maria Eugenia Caligiuri Maria Grazia Vaccaro Michele Trimboli Cristina Segura Garcia Pasquale De Fazio Antonio Gambardella Angelo Labate Psychiatric Assessment in Patients with Mild Temporal Lobe Epilepsy Behavioural Neurology |
| title | Psychiatric Assessment in Patients with Mild Temporal Lobe Epilepsy |
| title_full | Psychiatric Assessment in Patients with Mild Temporal Lobe Epilepsy |
| title_fullStr | Psychiatric Assessment in Patients with Mild Temporal Lobe Epilepsy |
| title_full_unstemmed | Psychiatric Assessment in Patients with Mild Temporal Lobe Epilepsy |
| title_short | Psychiatric Assessment in Patients with Mild Temporal Lobe Epilepsy |
| title_sort | psychiatric assessment in patients with mild temporal lobe epilepsy |
| url | http://dx.doi.org/10.1155/2019/4139404 |
| work_keys_str_mv | AT antonellabruni psychiatricassessmentinpatientswithmildtemporallobeepilepsy AT iolandamartino psychiatricassessmentinpatientswithmildtemporallobeepilepsy AT mariaeugeniacaligiuri psychiatricassessmentinpatientswithmildtemporallobeepilepsy AT mariagraziavaccaro psychiatricassessmentinpatientswithmildtemporallobeepilepsy AT micheletrimboli psychiatricassessmentinpatientswithmildtemporallobeepilepsy AT cristinaseguragarcia psychiatricassessmentinpatientswithmildtemporallobeepilepsy AT pasqualedefazio psychiatricassessmentinpatientswithmildtemporallobeepilepsy AT antoniogambardella psychiatricassessmentinpatientswithmildtemporallobeepilepsy AT angelolabate psychiatricassessmentinpatientswithmildtemporallobeepilepsy |