ECM-mimicking hydrogel models of human adipose tissue identify deregulated lipid metabolism in the prostate cancer-adipocyte crosstalk under antiandrogen therapy

ECM-mimicking hydrogel models of human adipose tissue identify deregulated lipid metabolism in the prostate cancer-adipocyte crosstalk under antiandrogen therapy

Antiandrogen therapies are effectively used to treat advanced prostate cancer, but eventually cancer adaptation drives unresolved metastatic castration-resistant prostate cancer (mCRPC). Adipose tissue influences metabolic reprogramming in cancer and was proposed as a contributor to therapy resistan...

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Bibliographic Details
Main Authors: Agathe Bessot, Joan Röhl, Maria Emmerich, Anton Klotz, Akhilandeshwari Ravichandran, Christoph Meinert, David Waugh, Jacqui McGovern, Jenni Gunter, Nathalie Bock
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Materials Today Bio
Subjects:
Adipose models
SGBS cells
Bone marrow adipocytes
Prostate cancer
Androgen receptor
Enzalutamide
Online Access:http://www.sciencedirect.com/science/article/pii/S259000642400485X
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