New pneumococcal serotype 20C is a WciG O-acetyltransferase deficient variant of canonical serotype 20B

New pneumococcal serotype 20C is a WciG O-acetyltransferase deficient variant of canonical serotype 20B

ABSTRACT The polysaccharide (PS) capsule of Streptococcus pneumoniae (pneumococcus) is the immunodominant surface structure that shields the bacteria from the host immune system. Since the capsule is the primary target of currently available pneumococcal vaccines, anti-capsular antibodies are highly...

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Bibliographic Details
Main Authors: Jigui Yu, Neil Ravenscroft, Peter Davey, Roshan Liyanage, Oliver Lorenz, Michelle M. Kuttel, Stephanie W. Lo, Feroze A. Ganaie, Moon H. Nahm
Format: Article
Language:English
Published: American Society for Microbiology 2025-01-01
Series:Microbiology Spectrum
Subjects:
Streptococcus pneumoniae
capsule polysaccharide
serogroup 20
O-acetyltransferase
vaccine
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02443-24
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https://journals.asm.org/doi/10.1128/spectrum.02443-24

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