Development of a monoclonal antibody to study MARCH6, an E3 ligase that regulates proteins that control lipid homeostasis

Development of a monoclonal antibody to study MARCH6, an E3 ligase that regulates proteins that control lipid homeostasis

Membrane-associated ring-CH-type finger 6 (MARCH6), also designated as TEB4 or RNF176, is an E3 ligase that is embedded in membranes of the endoplasmic reticulum where it ubiquitinates many substrate proteins to consign them to proteasome-mediated degradation. In recent years, MARCH6 has been identi...

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Bibliographic Details
Main Authors: Shimeng Xu, Linda Donnelly, Daniel L. Kober, Myra Mak, Arun Radhakrishnan
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Journal of Lipid Research
Subjects:
antibodies
cholesterol/biosynthesis
lipid droplets
sterols
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752400155X
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