Generation of an induced pluripotent stem cell line (HMSCATi004-A) from an early onset Parkinson’s disease patient with PRKN gene mutation
Parkin (PRKN) is recognized as causative gene in early-onset Parkinson’s disease (PD). Induced pluripotent stem cells (iPSCs) were derived from a 29-year-old PD patient carrying a heterozygous c.823C > T (p.R275W) variant and an exon 2–4 deletion in PRKN. The Generated iPSCs maintain a normal kar...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Stem Cell Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1873506124002769 |
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| author | Jingke Cheng Yingtong Zhai Xiangge Guo Xumeng Wang Min Ma Xin Ren Shan Wang Huixian Cui Qian Ren |
| author_facet | Jingke Cheng Yingtong Zhai Xiangge Guo Xumeng Wang Min Ma Xin Ren Shan Wang Huixian Cui Qian Ren |
| author_sort | Jingke Cheng |
| collection | DOAJ |
| description | Parkin (PRKN) is recognized as causative gene in early-onset Parkinson’s disease (PD). Induced pluripotent stem cells (iPSCs) were derived from a 29-year-old PD patient carrying a heterozygous c.823C > T (p.R275W) variant and an exon 2–4 deletion in PRKN. The Generated iPSCs maintain a normal karyotype, express pluripotency markers, and retain the ability to differentiate into the three germ layers. This iPSC line serves as a valuable cellular model for investigating the pathogenesis of early-onset PD and development of potential therapeutic interventions. |
| format | Article |
| id | doaj-art-34d686f3d1064b0abb11e80fbbd57b8b |
| institution | Kabale University |
| issn | 1873-5061 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Stem Cell Research |
| spelling | doaj-art-34d686f3d1064b0abb11e80fbbd57b8b2024-12-13T10:56:52ZengElsevierStem Cell Research1873-50612024-12-0181103578Generation of an induced pluripotent stem cell line (HMSCATi004-A) from an early onset Parkinson’s disease patient with PRKN gene mutationJingke Cheng0Yingtong Zhai1Xiangge Guo2Xumeng Wang3Min Ma4Xin Ren5Shan Wang6Huixian Cui7Qian Ren8Department of Human Anatomy, Hebei Medical University, Shijiazhuang, China; International Cooperation Laboratory of Stem Cell Research, Hebei Medical University, Shijiazhuang, ChinaDepartment of Human Anatomy, Hebei Medical University, Shijiazhuang, China; International Cooperation Laboratory of Stem Cell Research, Hebei Medical University, Shijiazhuang, ChinaDepartment of Human Anatomy, Hebei Medical University, Shijiazhuang, China; International Cooperation Laboratory of Stem Cell Research, Hebei Medical University, Shijiazhuang, ChinaDepartment of Human Anatomy, Hebei Medical University, Shijiazhuang, China; International Cooperation Laboratory of Stem Cell Research, Hebei Medical University, Shijiazhuang, ChinaDepartment of Human Anatomy, Hebei Medical University, Shijiazhuang, China; Human Brain Bank, Hebei Medical University, Shijiazhuang, ChinaDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, ChinaDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, ChinaDepartment of Human Anatomy, Hebei Medical University, Shijiazhuang, China; International Cooperation Laboratory of Stem Cell Research, Hebei Medical University, Shijiazhuang, China; Hebei Key Laboratory of Neurodegenerative Disease Mechanism, Hebei Medical University, Shijiazhuang, China; Corresponding authors.Department of Human Anatomy, Hebei Medical University, Shijiazhuang, China; International Cooperation Laboratory of Stem Cell Research, Hebei Medical University, Shijiazhuang, China; Hebei Key Laboratory of Neurodegenerative Disease Mechanism, Hebei Medical University, Shijiazhuang, China; The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Shijiazhuang, China; Corresponding authors.Parkin (PRKN) is recognized as causative gene in early-onset Parkinson’s disease (PD). Induced pluripotent stem cells (iPSCs) were derived from a 29-year-old PD patient carrying a heterozygous c.823C > T (p.R275W) variant and an exon 2–4 deletion in PRKN. The Generated iPSCs maintain a normal karyotype, express pluripotency markers, and retain the ability to differentiate into the three germ layers. This iPSC line serves as a valuable cellular model for investigating the pathogenesis of early-onset PD and development of potential therapeutic interventions.http://www.sciencedirect.com/science/article/pii/S1873506124002769 |
| spellingShingle | Jingke Cheng Yingtong Zhai Xiangge Guo Xumeng Wang Min Ma Xin Ren Shan Wang Huixian Cui Qian Ren Generation of an induced pluripotent stem cell line (HMSCATi004-A) from an early onset Parkinson’s disease patient with PRKN gene mutation Stem Cell Research |
| title | Generation of an induced pluripotent stem cell line (HMSCATi004-A) from an early onset Parkinson’s disease patient with PRKN gene mutation |
| title_full | Generation of an induced pluripotent stem cell line (HMSCATi004-A) from an early onset Parkinson’s disease patient with PRKN gene mutation |
| title_fullStr | Generation of an induced pluripotent stem cell line (HMSCATi004-A) from an early onset Parkinson’s disease patient with PRKN gene mutation |
| title_full_unstemmed | Generation of an induced pluripotent stem cell line (HMSCATi004-A) from an early onset Parkinson’s disease patient with PRKN gene mutation |
| title_short | Generation of an induced pluripotent stem cell line (HMSCATi004-A) from an early onset Parkinson’s disease patient with PRKN gene mutation |
| title_sort | generation of an induced pluripotent stem cell line hmscati004 a from an early onset parkinson s disease patient with prkn gene mutation |
| url | http://www.sciencedirect.com/science/article/pii/S1873506124002769 |
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