Cerebral Microbleeds and Antiplatelet Therapy in Mongolian and Han Patients with Ischemic Cerebrovascular Disease
Haichao Fu,1 Lihong Ge,1 Junguo Liang2 1Department of Diagnostic Imaging, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot City, Inner Mongolia, People’s Republic of China; 2Department of Thoracic Surgery, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot City,...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2024-12-01
|
| Series: | Journal of Multidisciplinary Healthcare |
| Subjects: | |
| Online Access: | https://www.dovepress.com/cerebral-microbleeds-and-antiplatelet-therapy-in-mongolian-and-han-pat-peer-reviewed-fulltext-article-JMDH |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846140192771014656 |
|---|---|
| author | Fu H Ge L Liang J |
| author_facet | Fu H Ge L Liang J |
| author_sort | Fu H |
| collection | DOAJ |
| description | Haichao Fu,1 Lihong Ge,1 Junguo Liang2 1Department of Diagnostic Imaging, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot City, Inner Mongolia, People’s Republic of China; 2Department of Thoracic Surgery, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot City, Inner Mongolia, People’s Republic of ChinaCorrespondence: Lihong Ge, Department of Diagnostic Imaging, The Affiliated Hospital of Inner Mongolia Medical University, No. 1 Tongdao North Street, Huimin District, Hohhot City, Inner Mongolia, 010000, People’s Republic of China, Tel +86 15304719599, Email gelihong_glh@163.com Junguo Liang, Department of Thoracic Surgery, The Affiliated Hospital of Inner Mongolia Medical University, No. 1 Tongdao North Street, Huimin District, Hohhot City, Inner Mongolia, 010000, People’s Republic of China, Email LiangJGguo@outlook.comObjective: To analyze the differences in cerebral microbleeds (CMBs) and their correlation with intracerebral hemorrhage (ICH) in Mongolian and Han Chinese patients with ischemic cerebrovascular disease.Methods: A total of 160 patients with ischemic cerebrovascular disease who took aspirin or clopidogrel for over one year were retrospectively analyzed, including 80 Mongolian and 80 han patients. The incidence, number, and distribution of CMBs were compared between groups. Logistic regression was used to identify risk factors for the occurrence of cerebral hemorrhage.Results: The detection rate of CMBs was significantly lower in Mongolian patients compared to Han patients (P = 0.040). Mongolian patients had a higher distribution of CMBs in the deep or infratentorial regions (66.6% vs 58.1%), while Han patients had a higher lobar distribution (P = 0.007). Prolonged antiplatelet therapy (over 3 years) was a risk factor for CMB development in both groups and was also linked to an increased risk of ICH. Patients with a higher number of CMBs had a greater likelihood of experiencing ICH.Conclusion: Mongolian patients had a lower likelihood of developing CMBs than Han patients, but with a higher deep or infratentorial distribution. The presence of CMBs, especially with long-term antiplatelet therapy, is a significant predictor of ICH. No significant difference in ICH risk was found between ethnic groups. Close monitoring of patients with CMBs during prolonged antiplatelet therapy is crucial to reduce hemorrhagic events.Keywords: cerebral microbleeds, antiplatelet drugs, intracerebral hemorrhage, white matter hyperintensities |
| format | Article |
| id | doaj-art-34cec7ceacb34c71a7bdaa3f570adbf7 |
| institution | Kabale University |
| issn | 1178-2390 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Multidisciplinary Healthcare |
| spelling | doaj-art-34cec7ceacb34c71a7bdaa3f570adbf72024-12-05T16:54:29ZengDove Medical PressJournal of Multidisciplinary Healthcare1178-23902024-12-01Volume 175789579897970Cerebral Microbleeds and Antiplatelet Therapy in Mongolian and Han Patients with Ischemic Cerebrovascular DiseaseFu HGe LLiang JHaichao Fu,1 Lihong Ge,1 Junguo Liang2 1Department of Diagnostic Imaging, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot City, Inner Mongolia, People’s Republic of China; 2Department of Thoracic Surgery, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot City, Inner Mongolia, People’s Republic of ChinaCorrespondence: Lihong Ge, Department of Diagnostic Imaging, The Affiliated Hospital of Inner Mongolia Medical University, No. 1 Tongdao North Street, Huimin District, Hohhot City, Inner Mongolia, 010000, People’s Republic of China, Tel +86 15304719599, Email gelihong_glh@163.com Junguo Liang, Department of Thoracic Surgery, The Affiliated Hospital of Inner Mongolia Medical University, No. 1 Tongdao North Street, Huimin District, Hohhot City, Inner Mongolia, 010000, People’s Republic of China, Email LiangJGguo@outlook.comObjective: To analyze the differences in cerebral microbleeds (CMBs) and their correlation with intracerebral hemorrhage (ICH) in Mongolian and Han Chinese patients with ischemic cerebrovascular disease.Methods: A total of 160 patients with ischemic cerebrovascular disease who took aspirin or clopidogrel for over one year were retrospectively analyzed, including 80 Mongolian and 80 han patients. The incidence, number, and distribution of CMBs were compared between groups. Logistic regression was used to identify risk factors for the occurrence of cerebral hemorrhage.Results: The detection rate of CMBs was significantly lower in Mongolian patients compared to Han patients (P = 0.040). Mongolian patients had a higher distribution of CMBs in the deep or infratentorial regions (66.6% vs 58.1%), while Han patients had a higher lobar distribution (P = 0.007). Prolonged antiplatelet therapy (over 3 years) was a risk factor for CMB development in both groups and was also linked to an increased risk of ICH. Patients with a higher number of CMBs had a greater likelihood of experiencing ICH.Conclusion: Mongolian patients had a lower likelihood of developing CMBs than Han patients, but with a higher deep or infratentorial distribution. The presence of CMBs, especially with long-term antiplatelet therapy, is a significant predictor of ICH. No significant difference in ICH risk was found between ethnic groups. Close monitoring of patients with CMBs during prolonged antiplatelet therapy is crucial to reduce hemorrhagic events.Keywords: cerebral microbleeds, antiplatelet drugs, intracerebral hemorrhage, white matter hyperintensitieshttps://www.dovepress.com/cerebral-microbleeds-and-antiplatelet-therapy-in-mongolian-and-han-pat-peer-reviewed-fulltext-article-JMDHcerebral microbleedsantiplatelet drugsintracerebral hemorrhagewhite matter hyperintensities |
| spellingShingle | Fu H Ge L Liang J Cerebral Microbleeds and Antiplatelet Therapy in Mongolian and Han Patients with Ischemic Cerebrovascular Disease Journal of Multidisciplinary Healthcare cerebral microbleeds antiplatelet drugs intracerebral hemorrhage white matter hyperintensities |
| title | Cerebral Microbleeds and Antiplatelet Therapy in Mongolian and Han Patients with Ischemic Cerebrovascular Disease |
| title_full | Cerebral Microbleeds and Antiplatelet Therapy in Mongolian and Han Patients with Ischemic Cerebrovascular Disease |
| title_fullStr | Cerebral Microbleeds and Antiplatelet Therapy in Mongolian and Han Patients with Ischemic Cerebrovascular Disease |
| title_full_unstemmed | Cerebral Microbleeds and Antiplatelet Therapy in Mongolian and Han Patients with Ischemic Cerebrovascular Disease |
| title_short | Cerebral Microbleeds and Antiplatelet Therapy in Mongolian and Han Patients with Ischemic Cerebrovascular Disease |
| title_sort | cerebral microbleeds and antiplatelet therapy in mongolian and han patients with ischemic cerebrovascular disease |
| topic | cerebral microbleeds antiplatelet drugs intracerebral hemorrhage white matter hyperintensities |
| url | https://www.dovepress.com/cerebral-microbleeds-and-antiplatelet-therapy-in-mongolian-and-han-pat-peer-reviewed-fulltext-article-JMDH |
| work_keys_str_mv | AT fuh cerebralmicrobleedsandantiplatelettherapyinmongolianandhanpatientswithischemiccerebrovasculardisease AT gel cerebralmicrobleedsandantiplatelettherapyinmongolianandhanpatientswithischemiccerebrovasculardisease AT liangj cerebralmicrobleedsandantiplatelettherapyinmongolianandhanpatientswithischemiccerebrovasculardisease |