First-in-human study of 99mTc-labeled fucoidan, a SPECT tracer targeting P-selectin

First-in-human study of 99mTc-labeled fucoidan, a SPECT tracer targeting P-selectin

Abstract Background Activation of endothelial cells and platelets in atherothrombosis is characterized by upregulation of P-selectin. As a consequence, P-selectin represents a potential target for molecular imaging to identify thrombosis at an early stage. Fucoidan is a polysaccharide ligand extract...

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Bibliographic Details
Main Authors: Reindert F. Oostveen, Kang H. Zheng, Yannick Kaiser, Nick S. Nurmohamed, Jeffrey Kroon, Tim C. de Wit, Edwin Poel, Joel Aerts, Francois Rouzet, Erik S. G. Stroes, Didier Letourneur, Hein J. Verberne, Cédric Chauvierre, Mia R. Ståhle
Format: Article
Language:English
Published: SpringerOpen 2024-11-01
Series:EJNMMI Research
Subjects:
Dosimetry
SPECT
Thrombus
P-selectin
Fucoidan
Online Access:https://doi.org/10.1186/s13550-024-01173-8
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