Unravelling the druggability and immunological roles of the SOCS-family proteins

Unravelling the druggability and immunological roles of the SOCS-family proteins

The Suppressor of Cytokine Signalling (SOCS) protein family play a critical role in cytokine signalling and regulation of the JAK/STAT pathway with functional consequences to the immune response. Members of this family are implicated in multiple different signalling cascades that drive autoimmune di...

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Bibliographic Details
Main Authors:	Dylan M. Lynch, Beth Forrester, Thomas Webb, Alessio Ciulli
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-11-01
Series:	Frontiers in Immunology
Subjects:	SOCS proteins E3 ligases small molecule inhibitors cell signalling Cullin RING E3 ligases targeted protein degradation
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1449397/full
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