Interruption of the visual cycle in a novel animal model induces progressive vision loss resembling Stargardts Disease

Interruption of the visual cycle in a novel animal model induces progressive vision loss resembling Stargardts Disease

Abstract Mutations in the gene ABCA4 coding for photoreceptor-specific ATP-binding cassette subfamily A member 4, are responsible for Stargardts Disease type 1 (STGD1), the most common form of inherited macular degeneration. STGD1 typically declares early in life and leads to severe visual handicap....

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Bibliographic Details
Main Authors: Fabiana Sassone, Catherine Estay-Ahumada, Michel J. Roux, Dominique Ciocca, Paola Rossolillo, Marie-Christine Birling, Janet R. Sparrow, Diego Montenegro, David Hicks
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Stargardt’s disease
Retinal degeneration
Animal model
Gene editing
Cone photoreceptors
Electrophysiology
Online Access:https://doi.org/10.1038/s41598-024-81869-y
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